Psychiatry & Behavioral Neurosciences

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* (MCOM Psychiatry Faculty Profile)

Rex Philpot

Rex Philpot, PhD

Assistant Professor, College of Medicine Psychiatry and Behavioral Neurosciences

Contact Info

  • 12901 Bruce B. Downs Blvd.
    Tampa FL 33612
  • Academic Email: philpot@usf.edu
  • Academic Phone: (813) 974-3823

Education

  • PHD, Cognitive and Neural Sciences, University of South Florida, 2004
  • MA, Psychology, University of South Florida, 1998

Interdisciplinary and Emerging Signature Programs

  • Neuroscience

Recent Publications

  • Wecker L Marrero-Rosado B, Engberg M, E, Johns B, E, and Philpot R, M. 3-Acetylpyridine Neurotoxicity in Mice. NeuroToxicology. 58: 143-152., 2017.
  • Philpot RM, Ficken M, Wecker L. Doxorubicin and cyclophosphamide lead to long-lasting impairment of spatial memory in female, but not male mice. Behavioural brain research. 307: 165-75, 2016.
  • Schroeder RA, Wecker L, Philpot RM. Obstacles and Opportunities for Cholinergic Drug Development in the Treatment of Cognitive Disorders. Current pharmaceutical design. 22(14) : 1981-5, 2016.
  • Philpot RM. Potential Use of Nicotinic Receptor Agonists for the Treatment of Chemotherapy-Induced Cognitive Deficits. Neurochemical research. 40(10) : 2018-31, 2015.
  • Lambert CS, Philpot RM, Engberg ME, Johns BE, Wecker L. Analysis of gait in rats with olivocerebellar lesions and ability of the nicotinic acetylcholine receptor agonist varenicline to attenuate impairments. Behavioural brain research. 291: 342-50, 2015.
  • Lambert, C.S., Philpot, R.M. (co-first author), Engberg, M.E., Johns, B.E., Kim, S.H. and Wecker, L. Gait analysis and the cumulative gait index (CGI): Translational tools to assess impairments exhibited by rats with olivocerebellar ataxia Behav. Brain Res.,. 1: 334-43, 2014.
  • Fernandez, J.W., Philpot, R.M., Marsh, P.J., Hartney, K.E. and Kozel, F.A. The need to expand access to electroconvulsive therapy: a retrospective analysis of a new academic service J. Psychiatr. Pract.. 20(4) : 308-15, 2014.
  • Fernandez, J.W., Grizzell, J.A., Philpot, R.M., and Wecker, L. Postpartum depression in rats: differences in swim test immobility, sucrose preference and nurturing behaviors Behav Brain Res.. 1: 75-82, 2014.
  • Philpot, R.M., Engberg, M.E. and Wecker, L. Ethanol Conditioned Place Preference and Alterations in ΔFosB Following Adolescent Nicotine Administration Differ in Rats Exhibiting High or Low Behavioral Reactivity to a Novel Environment Brain Res.,. 1: 101-8, 2014.
  • Grieco JC, Ciarlone SL, Gieron-Korthals M, Schoenberg MR, Smith AG, Philpot RM, Heussler HS, Banko JL, Weeber EJ. An open-label pilot trial of minocycline in children as a treatment for Angelman syndrome. BMC neurology. 14: 232, 2014.
  • Wecker, L., Engberg, M.E., Philpot, R.M., Lambert, C.S., Kang, C.W., Antilla, J.C., Bickford, P.C., Hudson, C.E., Zesiewicz, T.A. and Rowell, P.R. Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia Neuropharmacology. 73: 75-86, 2013.
  • Philpot RM, Engberg ME, Wecker L. Effects of nicotine exposure on locomotor activity and pCREB levels in the ventral striatum of adolescent rats. Behavioural brain research. 230(1) : 62-8, 2012.
  • Philpot RM, Wecker L, Kirstein CL. Repeated ethanol exposure during adolescence alters the developmental trajectory of dopaminergic output from the nucleus accumbens septi. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 27(8) : 805-15, 2009.
  • Philpot RM, Wecker L. Dependence of adolescent novelty-seeking behavior on response phenotype and effects of apparatus scaling. Behavioral neuroscience. 122(4) : 861-75, 2008.
  • Stansfield KH, Philpot RM, Kirstein CL. An animal model of sensation seeking: the adolescent rat. Annals of the New York Academy of Sciences. 1021: 453-8, 2004.
  • Philpot R, Kirstein C. Developmental differences in the accumbal dopaminergic response to repeated ethanol exposure. Annals of the New York Academy of Sciences. 1021: 422-6, 2004.
  • Vila JL, Philpot RM, Kirstein CL. Grid crossing: inability to compare activity levels between adolescent and adult rats. Annals of the New York Academy of Sciences. 1021: 418-21, 2004.
  • Torrella TA, Badanich KA, Philpot RM, Kirstein CL, Wecker L. Developmental differences in nicotine place conditioning. Annals of the New York Academy of Sciences. 1021: 399-403, 2004.
  • Philpot RM, Badanich KA, Kirstein CL. Place conditioning: age-related changes in the rewarding and aversive effects of alcohol. Alcoholism, clinical and experimental research. 27(4) : 593-9, 2003.
  • Philpot RM, McQuown S, Kirstein CL. Stereotaxic localization of the developing nucleus accumbens septi. Brain research. Developmental brain research. 130(1) : 149-53, 2001.
  • Bjugstad KB, Flitter WD, Garland WA, Philpot RM, Kirstein CL, Arendash GW. CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex. Journal of neurovirology. 6(6) : 478-91, 2000.
  • Donovan DM, Miner LL, Perry MP, Revay RS, Sharpe LG, Przedborski S, Kostic V, Philpot RM, Kirstein CL, Rothman RB, Schindler CW, Uhl GR. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. 73(1-2) : 37-49, 1999.
  • Philpot RM, Kirstein CL. Repeated cocaine exposure: effects on catecholamines in the nucleus accumbens septi of periadolescent animals. Pharmacology, biochemistry, and behavior. 62(3) : 465-72, 1999.
  • Philpot RM, Kirstein CL. The effects of repeated alcohol exposure on the neurochemistry of the periadolescent nucleus accumbens septi. Neuroreport. 9(7) : 1359-63, 1998.
  • Kirstein CL, Philpot RM, Dark T. Fetal alcohol syndrome: early olfactory learning as a model system to study neurobehavioral deficits. The International journal of neuroscience. 89(1-2) : 119-32, 1997.
  • Philpot, R.M., Ficken, M., Johns B.E., Engberg, M.E. and Wecker, L. Spatial memory deficits in mice induced by chemotherapeutic agents are prevented by acetylcholinesterase inhibitors. Cancer Chemotherapy and Pharmacology. 84(3) : 579-589, 2019.
  • Johns, B.E., Ficken, M. Engberg, M.E., Wecker, L. and Philpot, R.M. Increasing dietary choline attenuates spatial memory deficits resulting from exposure to the chemotherapeutic agents cyclophosphamide and doxorubicin. Journal of Psychopharmacology. 35(10) : 1300-1309, 2021.
  • Botelho, R., Kirstein, C.L.; Philpot, R.M. Cyclophosphamide- and Doxorubicin-induced Impairment of High-Affinity Choline Uptake and Spatial Memory Can Be Prevented by Dietary Choline Supplementation in Breast Tumor Bearing Mice. PLOSONE. , 2024.
  • Philpot, R.M. and Kalivas, P.W. Illicit Psychoactive Compounds and Substance Use Disorder. Brody’s Human Pharmacology: Mechanism-Based Therapeutics. 6th Ed: 202-214, 2018.
  • Philpot, R.M. and Wecker, L. Cannabinoids as Analgesics. Brody’s Human Pharmacology: Mechanism-Based Therapeutics. 6th Ed: 255-261, 2018.
  • Block, J.S. and Philpot, R.M. Psychoactive Compounds and Substance Use Disorder. Brody’s Human Pharmacology: Mechanism-Based Therapeutics. 7th Ed: 223-235, 2024.
  • Block, J.S., Philpot, R.M. and Wecker, L. Cannabinoids. Brody’s Human Pharmacology: Mechanism-Based Therapeutics. 7th Ed: 277-283, 2024.