Tampa General has served as a primary teaching facility for the University of South Florida College of Medicine since 1971. West central Florida's only level 1 trauma center, TGH also serves as a specialty referral center for the region. The hospital is nearing completion of an expansion that will significantly enlarge the emergency room and increase bed capacity to approximately 1,000. Located on the waterfront in scenic downtown Tampa, TGH provides an ideal environment for resident training.

Affiliated with U.S.F College of Medicine since its founding, the James A. Haley V.A. hospital has 327 acute care beds and the busiest outpatient clinic system of any VA facility in the country. The patient population provides a wide variety of pathology, including a large number of combat veterans from Operation Iraqi Freedom. Located across the street from the main campus, the hospital has convenient access to all of the College of Medicine's facilities including clinics and main library.

Founded in 1986, the Moffitt Cancer Center has rapidly grown into one of the premier cancer treatment facilities in the country. A National Cancer Institute Comprehensive Cancer Center that has been named one of the top ten cancer centers in the United States, Moffit is on the cutting edge of cancer research and treatment. Boasting a diverse patient population, world-renowned faculty and superb clinical and research facilities, Moffitt offers a truly unique training environment.

Located in downtown St. Petersburg, All Children's Hospital is one of only 48 freestanding children's hospitals in the U.S. and has the highest level of patient acuity in the country. An 11,000 square-foot pediatric emergency center treats children from a wide referral region. Centers of excellence for pediatric cardiac surgery and cardiac transplantation, cystic fibrosis, cleft palate surgery and developmental pediatrics serve children from throughout Florida and the United States. Annual admissions at All Children's Hospital approximate 7,000.

The USF Health clinic in South Tampa (next to Tampa General) provides primary care services for families. The clinic is the continuity care clinic for resident physicians in the combined Internal Medicine—Pediatric residency program at the University of South Florida. They are able to care for adults and children with acute or chronic problems.