Molecular Medicine

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* (Molecular Medicine Faculty Profile)

Michael N. Teng

Michael N. Teng, PhD

Associate Professor, Division of Allergy & Immunology, Department of Internal Medicine

Assoc Dean, PhD and Postdoctoral Programs, College of Medicine Internal Medicine

Contact Info

Education

  • PhD, Immunology, University of Chicago, 1993
  • B.S., Life Sciences, MIT, 1988

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Biomedical Engineering & Nanomedicine

Research Interests

  • We study the role of host-virus interactions in viral pathogenesis. In particular, we are interested in how respiratory syncytial virus affects host signal transduction pathways to enhance viral replication. We use a combination of biochemical, molecular and cell biological, and virological techniques to examine these questions.

Memberships

  • Member (American Society for Virology, 2004 - Present)
  • Member (American Society for Microbiology, 2000 - Present)
  • Member (American Association for the Advancement of Science, 1994 - Present)

Recent Publications

  • Wu W, Tran KC, Teng MN, Heesom KJ, Matthews DA, Barr JN, Hiscox JA. The Interactome of the Human Respiratory Syncytial Virus NS1 Protein Highlights Multiple Effects on Host Cell Biology. Journal of Virology. 86(15) : 7777-89, 2012.
  • Hotard, Anne L.|Shaikh, Fyza Y.|Lee, Sujin|Yan, Dan|Teng, Michael N.|Plemper, Richard K.|Crowe, James E.|Moore, Martin L. A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis Virology. 434(1) : 129–136, 2012.
  • Kim Tran, Sandra Fuentes, Biao He and Michael Teng. Inhibition of AKT Kinase Activity Decreases Replication of Human Respiratory Syncytial Virus World Allergy Organ J. (5) : S63–S64, 2012.
  • Abhijeet Bakre, Patricia Mitchell, Jonathan K. Coleman, Les P. Jones, Geraldine Saavedra, Michael Teng, S. Mark Tompkins,. Respiratory syncytial virus modifies microRNAs regulating host genes that affect virus replication J Gen Virol. 93: 2346-2356, 2012.
  • Boyapalle S Wong T Garay J Teng M San Juan-­Vergara H Mohapatra S Mohapatra S. Respiratory syncytial virus NS1 protein colocalizes with Mitochondrial Antiviral Signaling Protein MAVS following infection. PLoS One. 7: e29386, 2012.
  • Boyapalle, Sandhya|Wong, Terianne|Garay, Julio|Teng, Michael|San Juan-Vergara, Homero|Mohapatra, Subhra|Mohapatra, Shyam Respiratory Syncytial Virus NS1 Protein Colocalizes with Mitochondrial Antiviral Signaling Protein MAVS following Infection PLoS ONE. 7(2) : e29386, 2012.
  • Reena Ghildyal, Kim C. Tran, Michael N. Teng, Leon Caly, Hongmei Li, John Mills and David A. Jans. Nucleocytoplasmic trafficking of the matrix protein of respiratory syncytial virus: Role in infection J Antivir Antiretrovir. 4(4) , 2012.
  • Hanley LL, McGivern DR, Teng MN, Djang R, Collins PL, Fearns R. Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation. Virology. 406(2) : 241-52, 2010.
  • Ling Z, Tran KC, Teng MN. Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I. Journal of Virology. 83(8) : 3734-42, 2009.
  • Ghildyal R, Ho A, Dias M, Soegiyono L, Bardin PG, Tran KC, Teng MN, Jans DA. The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanism. Journal of Virology. 83(11) : 5353-62, 2009.
  • Ling Z, Tran KC, Arnold JJ, Teng MN. Purification and characterization of recombinant human respiratory syncytial virus nonstructural protein NS1. Protein Expression and Purification. 57(2) : 261-70, 2008.
  • Sun M, Fuentes SM, Timani K, Sun D, Murphy C, Lin Y, August A, Teng MN, He B. Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses. Journal of Virology. 82(1) : 105-14, 2008.
  • Fuentes S, Tran KC, Luthra P, Teng MN, He B. Function of the respiratory syncytial virus small hydrophobic protein. Journal of Virology. 81(15) : 8361-6, 2007.
  • Tran KC, He B, Teng MN. Replacement of the respiratory syncytial virus nonstructural proteins NS1 and NS2 by the V protein of parainfluenza virus 5. Virology. 368(1) : 73-82, 2007.
  • Ghildyal R, Li D, Peroulis I, Shields B, Bardin PG, Teng MN, Collins PL, Meanger J, Mills J. Interaction between the respiratory syncytial virus G glycoprotein cytoplasmic domain and the matrix protein. The Journal of general virology. 86(Pt 7) : 1879-84, 2005.
  • Tran KC, Collins PL, Teng MN. Effects of altering the transcription termination signals of respiratory syncytial virus on viral gene expression and growth in vitro and in vivo. Journal of virology. 78(2) : 692-9, 2004.
  • Johnson TR, Teng MN, Collins PL, Graham BS. Respiratory syncytial virus (RSV) G glycoprotein is not necessary for vaccine-enhanced disease induced by immunization with formalin-inactivated RSV. Journal of virology. 78(11) : 6024-32, 2004.
  • Spann KM, Collins PL, Teng MN. Genetic recombination during coinfection of two mutants of human respiratory syncytial virus. Journal of virology. 77(20) : 11201-11, 2003.
  • Polack FP, Teng MN, Collins PL, Prince GA, Exner M, Regele H, Lirman DD, Rabold R, Hoffman SJ, Karp CL, Kleeberger SR, Wills-Karp M, Karron RA. A role for immune complexes in enhanced respiratory syncytial virus disease. The Journal of experimental medicine. 196(6) : 859-65, 2002.
  • Teng MN, Collins PL. The central conserved cystine noose of the attachment G protein of human respiratory syncytial virus is not required for efficient viral infection in vitro or in vivo. Journal of Virology. 76(12) : 6164-71, 2002.
  • Lockey RF, Teng MN. Human passive cutaneous anaphylaxis in the 21st century: Worth the risk? The Journal of allergy and clinical immunology. , 2017.
  • Teng MN, Tran KC. Use of Minigenome Systems to Study RSV Transcription. Methods in molecular biology (Clifton, N.J.). 1442: 155-64, 2016.
  • Whelan JN, Tran KC, van Rossum DB, Teng MN. Identification of Respiratory Syncytial Virus Nonstructural Protein 2 Residues Essential for Exploitation of the Host Ubiquitin System and Inhibition of Innate Immune Responses. Journal of virology. 90(14) : 6453-63, 2016.
  • Whelan JN, Reddy KD, Uversky VN, Teng MN. Functional correlations of respiratory syncytial virus proteins to intrinsic disorder. Molecular bioSystems. 12(5) : 1507-26, 2016.
  • Johnson SM, McNally BA, Ioannidis I, Flano E, Teng MN, Oomens AG, Walsh EE, Peeples ME. Respiratory Syncytial Virus Uses CX3CR1 as a Receptor on Primary Human Airway Epithelial Cultures. PLoS Pathogens. 11(12) : e1005318, 2015.
  • Villenave R, Broadbent L, Douglas I, Lyons JD, Coyle PV, Teng MN, Tripp RA, Heaney LG, Shields MD, Power UF. Induction and Antagonism of Antiviral Responses in Respiratory Syncytial Virus-Infected Pediatric Airway Epithelium. Journal of Virology. 89(24) : 12309-18, 2015.
  • Bakre A, Wu W, Hiscox J, Spann K, Teng MN, Tripp RA. Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β. The Journal of General Virology. 96(11) : 3179-91, 2015.
  • Phan SI, Chen Z, Xu P, Li Z, Gao X, Foster SL, Teng MN, Tripp RA, Sakamoto K, He B. A respiratory syncytial virus (RSV) vaccine based on parainfluenza virus 5 (PIV5). Vaccine. 32(25) : 3050-7, 2014.
  • Bajorek M, Caly L, Tran KC, Maertens GN, Tripp RA, Bacharach E, Teng MN, Ghildyal R, Jans DA. The Thr205 phosphorylation site within respiratory syncytial virus matrix (M) protein modulates M oligomerization and virus production. Journal of Virology. 88(11) : 6380-93, 2014.
  • Whelan, Jillian N.|Tran, Kim C.|Cox, Ruan R.|van Rossum, Damian B.|Patterson, Randen L.|Teng, Michael Exploitation Of The Host Ubiquitin System By Respiratory Syncytial Virus Nonstructural Protein 2 Journal of Allergy and Clinical Immunology. 133(2) : AB283, 2014.
  • Webster Marketon JI, Corry J, Teng MN. The respiratory syncytial virus (RSV) nonstructural proteins mediate RSV suppression of glucocorticoid receptor transactivation. Virology. 449: 62-9, 2014.
  • Fuentes S, Crim RL, Beeler J, Teng MN, Golding H, Khurana S. Development of a simple, rapid, sensitive, high-throughput luciferase reporter based microneutralization test for measurement of virus neutralizing antibodies following Respiratory Syncytial Virus vaccination and infection. Vaccine. 31(37) : 3987-94, 2013.
  • Teng, Michael|Fitzhugh, David J.|Tran, Kim|Lockey, Richard F.|Collins, Peter Functional Characterization of A Cis-Acting Temperature Sensitive Mutation From A Respiratory Syncytial Virus Vaccine Candidate Journal of Allergy and Clinical Immunology. 131(2) : AB11, 2013.
  • Tian B, Zhao Y, Kalita M, Edeh CB, Paessler S, Casola A, Teng MN, Garofalo RP, Brasier AR. CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells. Journal of Virology. 87(12) : 7075-92, 2013.
  • Bakre A Mitchell P Coleman JK Jones LP Saavedra G Teng M Tompkins SM Tripp RA. Respiratory Syncytial Virus (RSV) Modifies MicroRNAs Regulating Host Genes Which Affect Virus Replication. J. Gen. Virol.. 93: 2346-56, 2012.
  • Teng MN. The non-structural proteins of RSV: targeting interferon antagonists for vaccine development. Infectious Disorders Drug Targets. 12(2) : 129-37, 2012.
  • Hotard AL, Shaikh FY, Lee S, Yan D, Teng MN, Plemper RK, Crowe JE, Moore ML. A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis. Virology. 434(1) : 129-36, 2012.