Jesper Madsen

Research Assistant Professor

Research Assistant Professor, COPH Center for GHIDR

Biography

We perform theoretical and computational scientific research in the broad fields of (bio-) physics and chemistry. Focus is directed toward the quantitative understanding on the molecular basis of biological processes pertinent to health and disease. Computer modeling and simulation are magnificent techniques for studying such structure-property relationships in unprecedented detail. Overarching research directions include: Development of highly efficient coarse-grained models that accurately capture the essential physics of the emergent collective behavior in biological processes. Using all-atom molecular dynamics simulations to study structural and dynamic changes of biological macromolecules, such cellular receptors and enzymes, in their native (often lipidic) environments. With the insight gained from such study, we advance the understanding of complex biological phenomena on a fundamental level. The ultimate aim is to gain mechanistic insights that will lead to novel avenues for potential treatments and guide the development of drug discovery efforts.