Our lab focuses on the impact of addiction, particularly alcoholism, across the lifespan. Specifically, we are interested in the stressors and developmental changes that make adolescents so susceptible to addiction, and in the effects of alcohol and other drugs of abuse on aging and in neuropsychiatric disorders. Secondarily, we are interested in the role of circadian rhythms in addiction, and the impact of alcohol abuse on neurodegeneration, especially Alzheimer's disease. We aim to better understand addiction in order to aid in the development of more effective strategies for treatment. To this end, we study both molecular and behavioral changes related to alcohol and drug abuse in cell lines, tissues, and in preclinical models of disease.
Awards/Honors
USF Faculty Outstanding Research Achievement Award (USF - 2023)
Memberships
Member (Society for Neuroscience, 2003 - Present)
Member (Society for Research on Biological Rhythms, 2011 - Present)
Member (Research Society on Alcohol, 2006 - Present)
Recent Publications
Stevanovic K, Yunus A, Joly-Amado A, Gordon M, Morgan D, Gulick D, Gamsby J. Disruption of normal circadian clock function in a mouse model of tauopathy.Experimental neurology. 294: 58-67, 2017.
Smith-McLallen A, Heller D, Vernisi K, Gulick D, Cruz S, Snyder RL. Comparative Effectiveness of Two Walking Interventions on Participation, Step Counts, and Health.American journal of health promotion : AJHP. 31(2) : 119-127, 2017.
Gamsby JJ Gulick D1. Chronic shifts in the length and phase of the light cycle increase intermittent alcohol drinking in C57BL/6J mice.Front Behav Neurosci. 9: 9, 2015.
Gamsby JJ, Gulick D. Chronic shifts in the length and phase of the light cycle increase intermittent alcohol drinking in C57BL/6J mice.Frontiers in Behavioral Neuroscience. 9: 9, 2015.
Hethorn WR, Ciarlone SL, Filonova I, Rogers JT, Aguirre D, Ramirez RA, Grieco JC, Peters MM, Gulick D, Anderson AE, L Banko J, Lussier AL, Weeber EJ. Reelin supplementation recovers synaptic plasticity and cognitive deficits in a mouse model for Angelman syndrome.The European Journal of Neuroscience. 41(10) : 1372-80, 2015.
Chau DT, Khokhar JY, Gulick D, Dawson R, Green AI. Desipramine enhances the ability of paliperidone to decrease alcohol drinking.Journal of Psychiatric Research. 69: 9-18, 2015.
Gulick D, Chau DT, Khokhar JY, Dawson R, Green AI. Desipramine enhances the ability of risperidone to decrease alcohol intake in the Syrian golden hamster.Psychiatry Research. 218(3) : 329-34, 2014.
Gamsby JJ, Templeton EL, Bonvini LA, Wang W, Loros JJ, Dunlap JC, Green AI, Gulick D. The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels.Behavioural Brain Research. 249: 15-21, 2013.
Akagbosu CO, Evans GC, Gulick D, Suckow RF, Bucci DJ. Exposure to kynurenic acid during adolescence produces memory deficits in adulthood.Schizophrenia Bulletin. 38(4) : 769-78, 2012.
Gulick D, Gould TJ. Nicotine acts in the anterior cingulate, but not dorsal or ventral hippocampus, to reverse ethanol-induced learning impairments in the plus-maze discriminative avoidance task.Addiction Biology. 16(1) : 176-88, 2011.
Elias GA, Gulick D, Wilkinson DS, Gould TJ. Nicotine and extinction of fear conditioning.Neuroscience. 165(4) : 1063-73, 2010.
Gulick D, Green AI. Role of caloric homeostasis and reward in alcohol intake in Syrian golden hamsters.Physiology & Behavior. 101(4) : 518-26, 2010.
Gulick, Danielle|Gould, Thomas J. Effects of ethanol and caffeine on behavior in C57BL/6 mice in the plus-maze discriminative avoidance task.Behavioral Neuroscience. 123(6) : 1271-8, 2009.
Gulick D, Gould TJ. The hippocampus and cingulate cortex differentially mediate the effects of nicotine on learning versus on ethanol-induced learning deficits through different effects at nicotinic receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 34(9) : 2167-79, 2009.
Gulick D, Gould TJ. Interactive effects of ethanol and nicotine on learning, anxiety, and locomotion in C57BL/6 mice in the plus-maze discriminative avoidance task.Neuropharmacology. 57(3) : 302-10, 2009.
Gulick D, Gould TJ. Interactive effects of ethanol and nicotine on learning in C57BL/6J mice depend on both dose and duration of treatment.Psychopharmacology. 196(3) : 483-95, 2008.
André JM, Gulick D, Portugal GS, Gould TJ. Nicotine withdrawal disrupts both foreground and background contextual fear conditioning but not pre-pulse inhibition of the acoustic startle response in C57BL/6 mice.Behavioural Brain Research. 190(2) : 174-81, 2008.
Gulick D, Gould TJ. Varenicline ameliorates ethanol-induced deficits in learning in C57BL/6 mice.Neurobiology of Learning and Memory. 90(1) : 230-6, 2008.
Gulick D, Gould TJ. Acute ethanol has biphasic effects on short- and long-term memory in both foreground and background contextual fear conditioning in C57BL/6 mice.Alcoholism, Clinical and Experimental Research. 31(9) : 1528-37, 2007.
Chau DT, Gulick D, Xie H, Dawson R, Green AI. Clozapine chronically suppresses alcohol drinking in Syrian golden hamsters.Neuropharmacology. 58(2) : 351-6, 2010.
