Molecular Medicine

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* (Molecular Medicine Faculty Profile)

Subhra Mohapatra

Subhra Mohapatra, PHD

Professor, College of Medicine Molecular Medicine

Contact Info

Education

  • PHD, Immunology, University of Manitoba, 1993
  • MS, Chemistry, Ravenshaw College, Utkal University, 1983

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cancer Biology

Research Interests

  • One of the major focus of my laboratory is to understand the role of onco-immune environment, which plays a critical role in tumor growth, drug resistance and recurrence. To this end, we have developed methods and technologies to expand cancer stem cells (CSCs) that drive tumor initiation and progression, identified novel drug candidates for targeting CSCs and sensitizing tumors to immune checkpoint blockers in colon and lung cancer models. Another focus of my laboratory has been to study chemokine signaling pathways involving spleen-brain axis in regulating neurodegeneration in traumatic injury patients. Toward these goals, we have developed in vitro models of blood-brain-barrier, in vivo rodent models, nose-to-brain delivery methods and anti-inflammatory agents. Since the COVID 19 pandemic, our lab has initiated studies to understand the neurotropism of SARS-CoV2 virus.

Awards/Honors

  • Excellence in Innovation Award (USF - 2018)
  • Excellence in Innovation Award (USF - 2014)
  • Academic Editor (PLOS One - 2014)
  • International Travel Grant (USF - 2013)
  • SIPAIID Travel Grant (SIPAIID - 2011)
  • Organotypic Culture Training Program Award (NIH/NCI - 2007)
  • Young Investigator Travel Award (AACR - 1996)
  • Postdoctoral Fellowship (• Manitoba Health Research Council - 1994)
  • Junior Research Fellowship (NCI-Canada - 1994)
  • Travel grant (• Canadian Society of Immunology - 1993)
  • Graduate Student Fellowship (Manitoba Health Research Council - 1991)
  • Graduate Student Fellowship (University of Manitoba - 1990)
  • Robert J Grasso Award for Outstanding Dedication to Graduate Education (USF - 2020)
  • Elected Fellow of National Academy of Inventors (NAI) (NAI - 2021)
  • Elected to American Institute for Medical and Biological Engineering (AIMBE) College of Fellows (AIMBE - 2022)
  • Elected to Academy of Science, Engineering and Medicine of Florida (ASEMFL) (ASEM-FL - 2023)

Memberships

  • Member (National Academic of Inventors, 2014 - Present)
  • Member (USF Senate, 2014 - Present)
  • Member (National Academic of Inventors USF Chapter, 2014 - Present)
  • Member (American Association of Cancer Research, 2001 - Present)

Recent Publications

  • Das T, Nair RR, Green R, Padhee S, Howell M, Banerjee J, Mohapatra SS, Mohapatra S. Actinomycin D Down-regulates SOX2 Expression and Induces Death in Breast Cancer Stem Cells. Anticancer research. 37(4) : 1655-1663, 2017.
  • Nair RR, Padhee S, Das T, Green R, Howell M, Mohapatra SS, Mohapatra S. Three- and Four-Dimensional Spheroid and FiSS Tumoroid Cultures: Platforms for Drug Discovery and Development and Translational Research. Critical reviews in therapeutic drug carrier systems. 34(3) : 185-208, 2017.
  • Cheung MB, Sampayo-Escobar V, Green R, Moore ML, Mohapatra S, Mohapatra SS. Respiratory Syncytial Virus-Infected Mesenchymal Stem Cells Regulate Immunity via Interferon Beta and Indoleamine-2,3-Dioxygenase. PloS one. 11(10) : e0163709, 2016.
  • Devkota J, Howell M, Mukherjee P, Srikanth H, Mohapatra S* and Phan MH. Magneto-reactance based detection of MnO nanoparticle-embedded Lewis lung carcinoma cells J. Appl. Phys.. 117: 17D123, 2015.
  • Wang T, Green R, Nair RR, Howell M, Mohapatra S, Guldiken R and Mohapatra S. Surface Acoustic Waves (SAW)-Based Biosensing for Quantification of Cell Growth in 2D and 3D Cultures. Sensors.. 15(12) : 32045-32055, 2015.
  • Boyapalle S Xu W Raulji P Mohapatra S and Mohapatra SS. A multiple siRNA-based anti- HIV/SHIV microbicide shows protection in both in vitro and in vivo models. Plos One.. 10(9) : e0135288, 2015.
  • Mohapatra S, Agrawal D, Pledger WJ. p27Kip1 regulates T cell proliferation. The Journal of biological chemistry. 276(24) : 21976-83, 2001.
  • Mohapatra S, Pledger WJ. Interdependence of cdk2 activation and interleukin-2Ralpha accumulation in T cells. The Journal of biological chemistry. 276(24) : 21984-9, 2001.
  • Mohapatra S, Yang X, Wright JA, Turley EA, Greenberg AH. Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression. The Journal of experimental medicine. 183(4) : 1663-8, 1996.
  • Chen Y, Takata M, Maiti PK, Mohapatra S, Mohapatra SS, Sehon AH. The suppressor factor of T suppressor cells induced by tolerogenic conjugates of ovalbumin and monomethoxypolyethylene glycol is serologically and physicochemically related to the alpha beta heterodimer of the T cell receptor. Journal of immunology (Baltimore, Md. : 1950). 152(1) : 3-11, 1994.
  • Mohapatra SS, Mohapatra S, Yang M, Ansari AA, Parronchi P, Maggi E, Romagnani S. Molecular basis of cross-reactivity among allergen-specific human T cells: T-cell receptor V alpha gene usage and epitope structure. Immunology. 81(1) : 15-20, 1994.
  • Chen Y, Mohapatra S, Mohapatra SS, Sehon AH. Cytokine gene expression of CD8+ suppressor T cells induced by tolerogenic conjugates of antigen and mPEG. Cellular immunology. 149(2) : 409-21, 1993.
  • Mohapatra S, Chen Y, Takata M, Mohapatra SS, Sehon AH. Analysis of T-cell receptor alpha beta chains of CD8+ suppressor T cells induced by tolerogenic conjugates of antigen and monomethoxypolyethylene glycol. Involvement of TCR alpha-CDR3 domain in immunosuppression. Journal of immunology (Baltimore, Md. : 1950). 151(2) : 688-98, 1993.
  • Venugopal G, Mohapatra S, Salo D, Mohapatra S. Multiple mismatch annealing: basis for random amplified polymorphic DNA fingerprinting. Biochemical and biophysical research communications. 197(3) : 1382-7, 1993.
  • Penn C, Katinik C, Cuevas J, Mohapatra SS, Mohapatra S Monitoring Neurovascular Changes in a Mouse Repetitive Traumatic Brain Injury Model. J Neurosci Methods. 393(6) : 109876, 2023.
  • Howell M, Green RJ, Cianne J, Dayhoffll GW, Uversky VN, Mohapatra SS and Mohapatra S EGFR TKI Resistance in Lung Cancer Cells using RNA Sequencing and Analytical Bioinformatic Tools J Biomolecular Struc and Dynamics. https://doi.org/10.1080/07391102.2022.2153269, 2022.
  • Green R, Mayisamy K, McGill AR, Martinez T, Chandran B, Blair LJ, Bickford PC, Mohapatra SS, Mohapatra S SARS-CoV-2 Infection Increases the Gene Expression Profile for Alzheimer’s Disease Risk Mol Ther Methods Clin Dev. DOI: 10.1016/j.omtm.2022.09.007, 2022.
  • Green R, Khalil R, Mohapatra SS, Mohapatra S Role of Cannabidiol for Improvement of the Quality of Life in Cancer Patients: Potential and Challenges Int. J. Mol. Sci. https://doi.org/10.3390/ijms232112956: 12956, 2022.
  • Jana ID, Bhattacharya P, Mayilsamy K , Banerjee S, Bhattacharje G , Das S , Aditya S , Ghosh A , McGill AR, Srikrishnan S, Das AK , Basak A, Mohapatra SS, Chandran B, Bhimsaria D, Mohapatra S*, Roy A*, Mondal A Targeting an evolutionarily conserved “E-L-L” motif in spike protein to identify a small 2 molecule fusion inhibitor against SARS-CoV-2 PNAS Nexus. https://doi.org/10.1093/pnasnexus/pgac198, 2022.
  • Ambardar S, Howell M, Mayilsamy K, McGill A, Green R, Mohapatra S Ultrafast-UV laser integrating cavity device for inactivation of SARS-CoV-2 and other viruses Scientific Reports. doi: 10.1038/s41598-022-13670-8, 2022.
  • Ramadan A, Mayilsamy K, McGill A, Ghosh A, Giulianotti M, Donow H, Mohapatra SS, Mohapatra S, Chandran B, Deschenes R and Roy A Identification of SARS-CoV-2 spike palmitoylation inhibitors that results in release of attenuated virus with reduced infectivity Viruses. https://doi.org/10.3390/v14030531, 2022.
  • Markoutsa E, Mayilsamy K, Gulick D, Mohapatra SS and Mohapatra S Extracellular vesicles derived from inflammation-educated stem cells reverse brain inflammation- Implication of miRNAs Molecular Therapy. doi.org/10.1016/j.ymthe.2021.08.008, 2021.
  • Howell M, Green R, McGill A, Khalil R, Dutta R, Mohapatra SS and Mohapatra S Activation of Intracellular Complement in Lungs of Patients with Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs Front Immunol. https: //doi.org/10.3389/fimmu.2021.700705, 2021.
  • Dutta R, Khalil R, Mayilsamy K, Green R, Howell R, Bharadwaj S, Mohapatra SS and Mohapatra S Combination Therapy of Mithramycin A and immune checkpoint inhibitor for the treatment of colorectal cancer in an orthotopic murine model Front Immunol. doi: 10.3389/fimmu.2021.706133, 2021.
  • Howell R, Green R, McGill A, Khalil R, Dutta R, Mohapatra S and Mohapatra SS SARS-CoV-2 Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer Cancers. https://doi.org/10.3390/cancers13112676, 2021.
  • Sagbas SS, Mohapatra S, Ayyala RS, Brethanabotla VR, Sahiner N A polyphenolic biomacromolecule prepared from a flavonoid: Catechin as degradable microparticles J Appld Pol Sci. DOI:10.1002/app.50576, 2021.
  • McGill A, Khalil R, Dutta R, Green R, Howell R, Mohapatra S and Mohapatra SS SARS-CoV-2 Immuno-pathogenesis and potential for diverse vaccines and therapies: Opportunities and Challenges Infect Dis Rep. https://doi.org/10.3390/idr13010013, 2021.
  • Khiev D, Mohamed ZA, Vichare R, Paulson R, Bhatia S, Mohapatra S, Lobo GP, Valapala M, Keur N, Passaglia CL, Mohapatra SS and Biswal M Emerging nano-formulations and nanomedicines applications for ocular drug delivery Nanomaterials. doi: 10.3390/nano11010173, 2021.
  • Denmark D, Mohapatra S and Mohapatra SS Point-of-Care Diagnostics: Molecularly Imprinted Polymers and Nanomaterials for Enhanced Biosensor Selectivity and Transduction Eur Biotech. DOI: 10.2478/ebtj-2020-0023, 2020.
  • Markoutsa E, McGill A, Jadav H, Mohapatra S and Mohapatra SS A Multifunctional Nanoparticle as a Prophylactic and Therapeutic approach targeting Respiratory Syncytial Virus Nanomedicine. DOI:10.1016/j.nano.2020.102325, 2020.
  • Mayilsamy K, Markoutsa E, Das M, Chopda P, Puro D, Kumar A, Gulick D, Willing A, Mohapatra SS and Mohapatra S Treatment with shCCL20-CCR6 nanodendriplexes and human mesenchymal stem cell therapy improves pathology in mice with repeated traumatic brain injury Nanomedicine. DOI: 10.1016/j.nano.2020.102247, 2020.
  • Wang T, Green R, Howell M, Martinez T, Dutta R, Mohapatra S, Mohapatra SS The Design and Characterization of a Gravitational Microfluidic Platform for Drug Sensitivity Assay in Colorectal Perfused Tumoroid Cultures Nanomedicine. DOI: 10.1016/j.nano.2020.102294, 2020.
  • Mohapatra SS, Frisina RD, Mohapatra S, Sneed K, Markoutsa E, Wang T, Dutta R, Damnjanovic R, Phan M, Denmark DJ, Biswal M, McGill AR, Green R, Howell M, Ghosh P, Gonzalez A, Ahmed NT, Borresen B, Farmer M, Gaeta M, Sharma K, Bouchard C, Gamboni Advances in Translational Nanotechnology: Challenges and Opportunities Appl Sci. doi:10.3390/app10144881, 2020.
  • Riddhi V, Garner I, Paulson R, Tzekov R, Sahiner N, Panguluri S, Mohapatra S, Mohapatra SS, Ayyala R, Sneed K, Biswal Biofabrication of chitosan-based nanomedicines and its potential use for translational ophthalmic applications. Appl Sci. https://doi.org/10.3390/app10124189, 2020.
  • Wong TM, Boyapalle S, Sampayo V, Nguyen HD, Bedi R, Kamath SG, Moore ML, Mohapatra S, Mohapatra SS. Respiratory syncytial virus (RSV) infection in elderly mice results in altered antiviral gene expression and enhanced pathology. PloS One. 9(2) : e88764, 2014.
  • Das M, Penn C, Martinez T, Mayilsamy K, McGill A, Willing A, Mohapatra SS and Mohapatra S COVID-19 Neurotropism and implications for therapy Neuroimmunol and Neuroinflammation. DOI: 10.20517/2347-8659.2020.36, 2020.
  • Das M, Wang C, Bedi R, Mohapatra SS, Mohapatra S. Magnetic micelles for DNA delivery to rat brains after mild traumatic brain injury. Nanomedicine : Nanotechnology, biology, and medicine. 10(7) : 1539-48, 2014.
  • Mohapatra SS, Mohapatra S, McGill A and Green R Molecular Mechanism-driven New Biomarkers and Therapies for Atopic Dermatitis J Allergy Clin Immunol. DOI: 10.1016/j.jaci.2020.04.039, 2020.
  • Bird G Boyapalle S Wong T Opoku-Nsiah K Bedi R Crannell WC Perry A Nguyen H Sampayo V Devareddy A Mohapatra S Mohapatra SS and Walensky L. Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection. J Clinical Investigation. 124: 2113-24, 2014.
  • Willing A, Das M, Howell M, Mohapatra SS and Mohapatra S Potential of Mesenchymal Stem Cells Alone, or in Combination, to Treat Traumatic Brain Injury CNS Neurosci Ther. DOI: 10.1111/cns.13300, 2020.
  • Mallela J, Ravi S, Jean Louis F, Mulaney B, Cheung M, Sree Garapati U, Chinnasamy V, Wang C, Nagaraj S, Mohapatra SS, Mohapatra S. Natriuretic Peptide receptor a signaling regulates stem cell recruitment and angiogenesis: a model to study linkage between inflammation and tumorigenesis. Stem Cells (Dayton, Ohio). 31(7) : 1321-9, 2013.
  • Howell M, Green R, Khalil R, Foran E, Quarni W, Nair R, Stevens S, Grinchuck A, Hanna A, Mohapatra SS and Mohapatra S Lung Cancer Cells Survive Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Exposure Through Upregulation of Cholesterol Synthesis FASEB Bio Advances. DOI: 10.1096/fba.2019-00081, 2020.
  • Howell M, Wang C, Mahmoud A, Hellermann G, Mohapatra SS, Mohapatra S. Dual-function theranostic nanoparticles for drug delivery and medical imaging contrast: perspectives and challenges for use in lung diseases. Drug Delivery and Translational Research. 3(4) : 352-363, 2013.
  • Green R, Howell M, Khalil R, Nair R, Yan J, Foran E, Katiri S, Banerjee J, Sachdeva M, Bharadwaj S, Mohapatra SS and Mohapatra S Actinomycin D and Telmisartan Combination Targets Lung Cancer Stem Cells Through the Wnt/Beta Catenin Pathway Scientific Reports. DOI: 10.1038/s41598-019-54266-z, 2019.
  • Wang C Sowndharya R Garapati U Das M Howell M Mallela J Subbiah A Mohapatra SS and Mohapatra . Multifunctional Chitosan-Magnetic Graphene (CMG) Nanoparticles: a Theranostic Platform for Tumor Targeted Co-delivery of Drugs, Genes and MRI Contrast Agents. J Materials Chemistry B.. 1: 4396-4405, 2013.
  • Quarni W, Dutta R, Katiri S, Patel B, Mohapatra SS and Mohapatra S Mithramycin A Inhibits Colorectal Cancer Growth by Targeting Cancer Stem Cells Scientific Reports. DOI: 10.1038/s41598-019-50917-3, 2019.
  • Devkota J Wang C Ruiz A Mohapatra S Mukherjee P Srikanth H and Phan MH. Detection of low-concentration superparamagnetic nanoparticles using an integrated RF magnetic biosensor. J Appl Physic. 113: 104701, 2013.
  • Das M, Mayilsamy K, Tang X, Han JY, Foran E, Willing A, Mohapatra SS and Mohapatra S Pioglitazone treatment prior to transplantation improves the efficacy of human mesenchymal stem cells after traumatic brain injury in rats Scientific Reports. DOI: 10.1038/s41598-019-49428-y, 2019.
  • Dutta R, Khalil R, Green R, Mohapatra SS, and Mohapatra S Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology Int. J. Mol. Sci. DOI:10.3390/ijms20215310 2019, 2019.
  • Huls NF Phan M Kumar A Mohapatra S Mohapatra SS Mukherjee P and Srikanth H. Transverse susceptibility as a biosensor for detection of Au-Fe3O4 nanoparticle-embedded human embryonic kidney cells. Sensors. 13(7) : 8490-8500, 2013.
  • Das M, Tang X, Han JY, Mayilsamy K, Foran E, Biswal M, Tzekov R, Mohapatra SS and Mohapatra S CCL20-CCR6 axis modulated traumatic brain injury-induced visual pathogenesis J Neuro Inflammation. DOI: 10.1186/s12974-019-1499-z 2019, 2019.
  • Dixit S Das M Alwarappan S Goicocha NL Howell M Mohapatra S and Mohapatra SS. Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery. RSC Advances. 3: 2727-2735, 2013.
  • Wang C, Mallela J, Garapati US, Ravi S, Chinnasamy V, Girard Y, Howell M, Mohapatra S. A chitosan-modified graphene nanogel for noninvasive controlled drug release. Nanomedicine : Nanotechnology, biology, and medicine. 9(7) : 903-11, 2013.
  • Das M, Mayilsamy K, Mohapatra SS and Mohapatra S Mesenchymal Stem cell therapy for the treatment of traumatic brain injury: progress and prospects Reviews in Neurosciences. DOI.org/10.1515/revneuro-2019-0002, 2019.
  • Howell M, Mallela J, Wang C, Ravi S, Dixit S, Garapati U, Mohapatra S. Manganese-loaded lipid-micellar theranostics for simultaneous drug and gene delivery to lungs. Journal of Controlled Release : Official journal of the Controlled Release Society. 167(2) : 210-8, 2013.
  • Wang T, Wang J, Mohapatra S, Mohapatra SS and Guldiken R Perturbation analysis of a multiple layer-guided Love Wave Sensor in a visoelastic environment Sensors. DOI: /10.3390/s19204533., 2019.
  • Girard YK, Wang C, Ravi S, Howell MC, Mallela J, Alibrahim M, Green R, Hellermann G, Mohapatra SS, Mohapatra S. A 3D fibrous scaffold inducing tumoroids: a platform for anticancer drug development. PloS One. 8(10) : e75345, 2013.
  • Denmark DJ, Bustos-Perez X, Swain A, Phan MH, Mohapatra S, and Mohapatra SS Readiness of Magnetic Nanobiosensors for Point-of-Care Commercialization Journal of Electronic Materials. DOI: 10.1007/s11664-019-07275-7, 2019.
  • Boyapalle S, Mohapatra S, Mohapatra S. Nanotechnology Applications to HIV Vaccines and Microbicides. Journal of Global Infectious Diseases. 4(1) : 62-8, 2012.
  • Wang T, Green R, Guldiken R, Wang J, Mohapatra S, and Mohapatra SS Finite element analysis for surface acoustic wave device characteristic properties and sensitivity Sensors. https://doi.org/10.3390/s19081749, 2019.
  • Das M Mohapatra S and Mohapatra SS. New Perspectives on central and peripheral immune responses to acute traumatic brain injury. J Neuroinflammation. 9: 236, 2012.
  • Udoka O, Green R, Mohapatra S and Anderson B The trimeric autotransporter adhesion, BadA, is required for in vitro biofilm formation by Bartonella Hanselae Npj Biofilms and Microbiomes. DOI: doi.org/10/1038/s41522-019-0083-8, 2019.
  • Wang C Sowndharya R Martinez G Chinnasamy V Raulji P Howell M Davis Y Mohindar S and Mohapatra . Dual-purpose magnetic micelles for MRI and gene delivery. J Cont Rel. 163: 82-82, 2012.
  • Wang T, Green R, Guldiken R, Mohapatra S, and Mohapatra SS Multiple-Layer Guided Surface Acoustic Wave (SAW)-Based pH Sensing in Longitudinal FiSS-Tumoroid Culture J Biosensor and Bioelectronics. 124-125(244252) , 2019.
  • Das M, Tang X, Mohapatra SS and Mohapatra S Vision Impairment after traumatic brain injury: Present knowledge and future direction Reviews in Neuroscience. DOI: doi.org/10.1515/revneuro-2018-0015., 2019.
  • Boyapalle S, Wong T, Garay J, Teng M, San Juan-Vergara H, Mohapatra S, Mohapatra S. Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection. PloS One. 7(2) : e29386, 2012.
  • Das M, Mohapatra SS and Mohapatra S The transitioning from stem cells to stem cell-derived exosomes for treatment of neurodegenerative conditions Ann Stem Cell Res Ther. 2(3) : 1017, 2018.
  • Wang C, Ravi S, Martinez GV, Chinnasamy V, Raulji P, Howell M, Davis Y, Mallela J, Seehra MS, Mohapatra S. Dual-purpose magnetic micelles for MRI and gene delivery. Journal of Controlled Release : Official journal of the Controlled Release Society. 163(1) : 82-92, 2012.
  • Mohapatra SS, Batra SK, Bharadwaj S, Bouvet M, Cosman B, Goel A, Jogunoori W, Kelley M, Mishra L, Mishra B, Mohapatra S, Patel B, Pisegna J, Raufman J, Rao S, Roy H, Scheuner M, and Singh S, Vidyarthi G, White J . Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions Digestive Diseases and Sciences. doi.org/10.1007/s10620-018-5000-0, 2018.
  • Mohapatra SS Mohapatra S Boyapalle S and Hellerman G. Multifunctional chitosannanocarriers for gene therapy. Technology and Innovation. 13: 27-37, 2011.
  • Sampayo-Escobar V, Green M, Cheung M, Bedi R, Mohapatra S and Mohapatra SS Osteopontin plays a pivotal role in increasing severity of respiratory syncytial infection PloS One. 13(4): e0192709 (2018), 2018.
  • Davis Y Mohapatra SS and Mohapatra S. Three-dimensional (3D) scaffolds in nano-bio interphase research. Technology and Innovation. 13: 51-62, 2011.
  • Sanchez-Ramos J, Song S, Kong X, Foroutan P, Martinez G, Dominguez-Viqueria W, Mohapatra SS, Mohapatra S, Haraszil R, Khvorova A, Aronin N and Sava V Chitosan-mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain J Drug Delivery Science and Technology. 43: 453-460, 2018.
  • Das M Rangoni S Pennypacker K Mohapatra S. and Mohapatra SS. Lateral fluid percussion injury of the brain induces CCL20 inflammatory cytokine expression in rats. J Neuroinflammation. 8: 148, 2011.
  • Rodgers JL, Samal E, Mohapatra S, and Panguluri SK Hyperoxia-induced cardiotoxicity and ventricular remodeling in type-II diabetes mice Heart and Vessels. doi.org/10.1007/s00380-017-1100-6 (2018), 2018.
  • Wang X, Raulji P, Mohapatra SS, Patel R, Hellermann G, Kong X, Vera PL, Meyer-Siegler KL, Coppola D, Mohapatra S. Natriuretic peptide receptor a as a novel target for prostate cancer. Molecular Cancer. 10: 56, 2011.
  • Vysotskaya Z, Chidipi B, Rodgers JL, Tang X, Samal E, Kolliputi N, Mohapatra S, Bennett E and Panguluri SK Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes J Cellular Physiology. doi: 10.1002/jcp.26263 (2018), 2018.
  • Wang JW, Li K, Hellermann G, Lockey RF, Mohapatra S, Mohapatra S. Regulating the Regulators: microRNA and Asthma. The World Allergy Organization journal. 4(6) : 94-103, 2011.
  • Das M, Howell M, Foran E, Iyre R, Mohapatra SS and Mohapatra S Sertoli cell loaded with doxorubicin in lipid micelles reduced tumor burden and doxorubicine-induced toxicity Cell Transplantatio. 26(10) : 1694-1702, 2017.
  • Wang C, Howell M, Raulji P, Davis Y, Mohapatra S. Preparation and Characterization of Molecularly Imprinted Polymeric Nanoparticles for Atrial Natriuretic Peptide (ANP). Advanced Functional Materials. 21(23) : 4423-4429, 2011.
  • Das T, Nair R, Green R, Padhee S, Howell M, Banerjee J, Mohapatra SS and Mohapatra S Actinomycin D down-regulates SOX2 expression and induces death in breast cancer stem cells Anticancer Research. 37(4) : 1655-1663, 2017.
  • 3. Khalil R, Green R, Sivakumar K, Varandani P, Bharadwaj S, Mohapatra SS and Mohapatra S Withaferin A Increases the Effectiveness of Immune Checkpoint Blockers for the Treatment of Non-Small Cell Lung Cancer Cancers. 15: 3089, 2023.
  • Zhang W, Cao X, Chen D, Wang JW, Yang H, Wang W, Mohapatra S, Hellermann G, Kong X, Lockey RF, Mohapatra SS. Plasmid-encoded NP73-102 modulates atrial natriuretic peptide receptor signaling and plays a critical role in inducing tolerogenic dendritic cells. Genetic Vaccines and Therapy. 9(1) : 3, 2011.
  • Kandasamy R, Park SJ, Boyapalle S, Mohapatra S, Hellermann GR, Lockey RF, Mohapatra SS. Isatin down-regulates expression of atrial natriuretic peptide receptor A and inhibits airway inflammation in a mouse model of allergic asthma. International Immunopharmacology. 10(2) : 218-25, 2010.
  • Kumar A, Jena PK, Behera S, Lockey RF, Mohapatra S, Mohapatra S. Multifunctional magnetic nanoparticles for targeted delivery. Nanomedicine : nanotechnology, biology, and medicine. 6(1) : 64-9, 2010.
  • Wang X, Xu W, Kong X, Chen D, Hellermann G, Ahlert TA, Giaimo JD, Cormier SA, Li X, Lockey RF, Mohapatra S, Mohapatra SS. Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma. Respiratory Research. 10: 66, 2009.
  • Bagui TK, Cui D, Roy S, Mohapatra S, Shor AC, Ma L, Pledger WJ. Inhibition of p27Kip1 gene transcription by mitogens. Cell cycle (Georgetown, Tex.). 8(1) : 115-24, 2009.
  • Mohapatra S, Chu B, Zhao X, Djeu J, Cheng JQ, Pledger WJ. Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors. The international journal of biochemistry & cell biology. 41(3) : 595-602, 2009.
  • Wang X, Xu W, Mohapatra S, Kong X, Li X, Lockey RF, Mohapatra SS. Prevention of airway inflammation with topical cream containing imiquimod and small interfering RNA for natriuretic peptide receptor. Genetic vaccines and therapy. 6: 7, 2008.
  • Kong X, Wang X, Xu W, Behera S, Hellermann G, Kumar A, Lockey RF, Mohapatra S, Mohapatra SS. Natriuretic peptide receptor a as a novel anticancer target. Cancer research. 68(1) : 249-56, 2008.
  • Mohapatra S, Coppola D, Riker AI, Pledger WJ. Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma. Molecular cancer research : MCR. 5(2) : 145-51, 2007.
  • Wang C, Hou X, Mohapatra S, Ma Y, Cress WD, Pledger WJ, Chen J. Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism. The Journal of biological chemistry. 280(13) : 12339-43, 2005.
  • Zhang W, Yang H, Kong X, Mohapatra S, San Juan-Vergara H, Hellermann G, Behera S, Singam R, Lockey RF, Mohapatra SS. Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nature medicine. 11(1) : 56-62, 2005.
  • Mohapatra S, Chu B, Zhao X, Pledger WJ. Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells. Cancer research. 65(17) : 7717-23, 2005.
  • Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R, Pledger WJ. Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer research. 63(23) : 8523-30, 2003.
  • Bagui TK, Mohapatra S, Haura E, Pledger WJ. P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes. Molecular and cellular biology. 23(20) : 7285-90, 2003.