Molecular Medicine

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* (Molecular Medicine Faculty Profile)

Charles Szekeres

Charles Szekeres, PHD

Assistant Professor, Molecular Medicine

Director, Flow Cytometry Facility Cytometry, Molecular Medicine

Biological Scientist, Office of Research

Contact Info

Education

  • PHD, Wayne State University, 2000
  • PhD, Cancer Biology, Wayne State University, 2000
  • MS, Biology, Eotvos University, 1993

Awards/Honors

  • Post Doctoral fellowship (National Kidney Foundation - 2001)
  • Travel Grant (United Nations IDO - 1994)

Recent Publications

  • da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, Iruela-Arispe ML, Dipersio CM, Kreidberg JA, Hodivala-Dilke KM. 1. Endothelial ±3²1-Integrin Represses Pathological Angiogenesis and Sustains Endothelial-VEGF Am J Pathology. 3(117) : 1534-1548, 2010.
  • L Lebson, K Nash, S Kamath, D Herber, N Carty, DC. Lee, Q Li, K Szekeres, U Jinwal, J Koren, CA. Dickey, PE. Gottschall, D Morgan, MN. Gordon. Trafficking CD11b-Positive Blood Cells Deliver Therapeutic Genes to the Brain of Amyloid-Depositing Transgenic Mice The Journal of Neuroscience. 29(30) : 96519658, 2010.
  • Stanco A, Szekeres C, Patel N, Rao S, Campbell K, Kreidberg JA, Polleux F, Anton ES. Netrin-1-alpha3beta1 integrin interactions regulate the migration of interneurons through the cortical marginal zone. Proceedings of the National Academy of Sciences of the United States of America. 106(18) : 7595-600, 2009.
  • Mitchell K, Szekeres C, Milano V, Svenson KB, Nilsen-Hamilton M, Kreidberg JA, DiPersio CM. Alpha3beta1 integrin in epidermis promotes wound angiogenesis and keratinocyte-to-endothelial-cell crosstalk through the induction of MRP3. Journal of cell science. 122(Pt 11) : 1778-87, 2009.
  • Liu Y, Chattopadhyay N, Qin S, Szekeres C, Vasylyeva T, Mahoney ZX, Taglienti M, Bates CM, Chapman HA, Miner JH, Kreidberg JA. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development (Cambridge, England). 136(5) : 843-53, 2009.
  • Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. The Journal of clinical investigation. 119(1) : 213-24, 2009.
  • Szekeres CK, Trikha M, Honn KV. 12(S)-HETE, pleiotropic functions, multiple signaling pathways. Advances in experimental medicine and biology. 507: 509-15, 2002.
  • Nie D, Lamberti M, Zacharek A, Li L, Szekeres K, Tang K, Chen Y, Honn KV. Thromboxane A(2) regulation of endothelial cell migration, angiogenesis, and tumor metastasis. Biochemical and biophysical research communications. 267(1) : 245-51, 2000.
  • Nie D, Tang K, Szekeres K, Li L, Honn KV. Eicosanoid regulation of angiogenesis in human prostate carcinoma and its therapeutic implications. Annals of the New York Academy of Sciences. 905: 165-76, 2000.
  • Nie D, Tang K, Szekeres K, Trikha M, Honn KV. The role of eicosanoids in tumor growth and metastasis. Ernst Schering Research Foundation workshop. (31) : 201-17, 2000.
  • Szekeres CK, Tang K, Trikha M, Honn KV. Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells. The Journal of biological chemistry. 275(49) : 38831-41, 2000.
  • Szekeres CK, Trikha M, Nie D, Honn KV. Eicosanoid 12(S)-HETE activates phosphatidylinositol 3-kinase. Biochemical and biophysical research communications. 275(2) : 690-5, 2000.
  • Timar J, Trikha M, Szekeres K, Bazaz R, Honn K. Expression and function of the high affinity alphaIIbbeta3 integrin in murine melanoma cells. Clin Exp Metastasis.. 5(16) : 437-45, 1998.
  • Timar J, Tovari J, Szekeres K, Kagawa D, Honn KV. Key determinants of the invasion mechanism of melanoma. Role for a new signaling pathway. Adv Exp Med Biol.. (407) : 303-10, 1997.
  • Trikha M, Timar J, Lundy SK, Szekeres K, Cai Y, Porter AT, Honn KV. The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells. Cancer research. 57(12) : 2522-8, 1997.
  • Trikha M, Timar J, Lundy SK, Szekeres K, Tang K, Grignon D, Porter AT, Honn KV. Human prostate carcinoma cells express functional alphaIIb(beta)3 integrin. Cancer research. 56(21) : 5071-8, 1996.
  • Timar J, Trikha M, Szekeres K, Bazaz R, Silletti S, Raz A, and Honn KV. Autocrine motility factor signals integrin mediated metastatic melanoma cell adhesion and invasion Cancer Research. (56) : 1902-08, 1996.

Positions Held

  • Instructor (Medical School, SIU 2006 - 2006)
  • Postdoctoral Fellow (Dept of Nephrology, Children's Hospital 2000 - 2005)