Diabetes Clinical Research: Finding a Cure

Currently Enrolling T1D Studies

TrialNet Pathway to Prevention Study

For individuals between the ages of 2.5-45 years with a first-degree relative (parent, child, sibling) with type 1 diabetes
For individuals between the ages of 2.5-20 years with a second-degree relative (grandparent, aunt, uncle, niece, nephew, cousin or half-sibling) with type 1 diabetes

Purpose: To identify individuals at-risk for T1D and offer close monitoring for disease progression as well as potential prevention study opportunities.

For more information visit TrialNet on the web.

Study Cordinator: Juanita O'Brian, NRCMA

Contact: usfdiabetesresearchc@usf.edu

TrialNet Abatacept T1D Prevention Study

For individuals > 6 years
Positive for two or more diabetes-related auto-antibodies
Normal Glucose Tolerance

Purpose: To prevent or delay disease progression in Stage 1 Type 1 individuals (2 or more auto-antibodies and normal glucose tolerance).

Study Coordinator: Juanita O'Brian, NRCMA

Contact: usfdiabetesresearchc@usf.edu

TrialNet Hydroxychloroquine T1D Prevention Study

For individuals > 3 years old
Positive for two or more diabetes-related auto-antibodies
Normal Glucose Tolerance

Purpose: To prevent or delay disease progression in Stage 1 Type 1 individuals (2 or more auto-antibodies and normal glucose tolerance).

Study Coordinator: Juanita O'Brian, NRCMA

Contact: usfdiabetesresearchc@usf.edu

Intrexon T1D New Onset Study

For individuals > 12 years old
Diagnosed with Type 1 Diabetes within 150 days

Purpose: To preserve insulin production by preventing beta cell destruction in individuals newly diagnosed with T1D.

Study Coordinator: Ponja Hemphill, RN

Contact: usfdiabetesresearchc@usf.edu

PROTECT New-Onset Study for Children and Adolescents with T1D

For Individuals ages 8-17
Diagnosed with T1D within 42 days
Up to date on immunizations

Purpose: To determine whether an investigational drug called Teplizumab may help preserve insulin production in children and adolescents who were recently diagnosed with Type 1 Diabetes

Study Coordinator: Ponja Hemphill, RN

Contact: usfdiabetesresearchc@usf.edu

Dexcom COACH Device Study for Children and Adolescents with T1D and T2D

For individuals ages 2-17
Diagnosed with type 1 diabetes or insulin-requiring type 2 diabetes
Has NOT used a Continuous Glucose Monitoring device (CGM) in the last year

Purpose: To evaluate the safety of non-adjunctive CGM use in CGM naive participants, by assessing the number of hypoglycemic and diabetic ketoacidosis (DKA) events with use of CGM

Study Coordinator: Janet Rodriguez, BSN, RN, CDCES, CRA-USF/BASIC

Contact: usfdiabetesresearchc@usf.edu

Currently Enrolling T2D Studies

Boehringer Ingelheim Type 2 Treatment Study (Linagliptin and Empagliflozin) for Pediatric Patients

For individuals ages 10-17
Diagnosed with type 2 diabetes for at least 12 weeks
Additional eligibility criteria will be reviewed with you by the study coordinator

Purpose: To test the safety and effectiveness of Linagliptin in combination with Empagliflozin (FDA approved for treatment of type 2 adults) in pediatric type 2 patients.

Study Coordinator: Janet Rodriguez, BSN, RN, CDCES, CRA-USF/BASIC

Contact: usfdiabetesresearchc@usf.edu

TEDDY Study compares characteristics of children diagnosed with type 1 diabetes before and after age 6

New findings from the international The Environmental Determinants of Diabetes in the Young (TEDDY) study add to the growing body of evidence indicating that type 1 diabetes is not a single disease.

Click here to view full article.

USF Awarded Four-Year, $69.9 Million NIH Grant to Continue Type 1 Diabetes Research

The Environmental Determinants of Diabetes in the Young study is led by USF Health’s Jeffrey Krischer, who has built a worldwide epidemiological hub for T1D research at USF.

Click here to view full article.

Nature highlights USF Health-led TEDDY study as a diabetes research milestone

Click here to view article.

USF Health Informatics Institute contributes to new NIH study indicating that measuring gene expression changes over time may help predict type 1 diabetes progression in at-risk children, and lead to earlier diagnosis of the autoimmune disease.

Click here to read the full article.