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Research

Danielle Tometich

Real-Life Assessment and Intervention in Behavioral Oncology Lab (RAINBO LAB)

The overall goal of the work in the RAINBO Lab is to improve the quality of life during and after cancer.

Cancer has touched the lives of nearly all of us – either directly or through a loved one’s diagnosis. Worldwide, cancer is a leading cause of death and disability. According to the WHO and Global Cancer Statistics from 2020, over 19 million cases of cancer are diagnosed each year, with over 400,000 cases in children.  Although the number of new cancer cases is staggering, new treatment approaches offer hope—death rates due to cancer are declining. In fact, 33% fewer people are dying from cancer now compared to 30 years ago. This is wonderful news, and yet, as more of the population joins the ranks of “cancer survivors” (people living after cancer treatment) or “thrivers/meta-vivors” (people living with advanced cancer), more work needs to be done to address the needs of those living with and beyond cancer.

The overall goal of the work in the RAINBO Lab is to improve the quality of life during and after cancer. Thus far, we have worked toward this goal by focusing on a few key areas that affect quality of life. One of those areas is cancer-related cognitive impairment (colloquially known as “chemobrain” or “chemofog”). Currently, cancer-related cognitive impairment has been difficult to measure and quantify using gold-standard neuropsychological testing, so for this first pillar of work, we use real-time and technology-assisted assessments to quantify ecologically valid variability in cognitive performance. Another area is understanding how health behaviors, which are potentially modifiable, affect cognitive functioning, fatigue, and mental health after cancer. This second pillar of work empowers those living with and after cancer with information about what they can change to enhance their well-being. Finally, we also study the side-effects and long-term effects of new treatments for advanced staged and metastatic cancers. This third pillar of work informs treatment decisions and symptom management to maximize quality of life during potentially short-term or uncertain prognoses.

Meet The Team

Danielle Tometich

Danielle Tometich, PhD -- Principal Investigator

Dr. Tometich is an Assistant Professor in the USF College of Nursing. She completed a postdoctoral fellowship at Moffitt Cancer Center after completing her clinical internship at Yale University and graduating with her PhD from Indiana University-Purdue University Indianapolis. Her research foci are: cancer-related cognitive impairment, health behavior change for symptom management, and patient-reported outcomes of novel cancer treatments. As a clinical psychologist by training, her guiding theoretical frameworks are biopsychosocial and socio-ecological. Her doctoral dissertation work, funded by an NRSA F31 award from the National Cancer Institute (NCI), focused on examining bidirectional associations between physical activity and executive cognitive function among older cancer survivors. While completing her postdoctoral fellowship at Moffitt Cancer Center on the NCI T32 in Behavioral Oncology, she conducted two pilot studies of patient-reported outcomes of immunotherapy for melanoma and renal cell carcinoma, and then received an NCI K99/R00 award to support her research examining cancer-related cognitive impairment in young adult cancer survivors. Outside of work she enjoys listening to audiobooks, sewing, and practicing aerial circus arts.

Melissa Bogle

Melissa Bogle, DNP, FNP-BC, ACNP-BC, PMHNP-BC, MPH, FAANP -- Co-Investigator

Dr. Melissa Bogle is an Assistant Professor at the University of South Florida whose career bridges primary care, mental health, and health‑equity–driven workforce development. She currently practices both primary and psychiatric care through a national telehealth organization, bringing an integrated approach to patients who often struggle to access services. Her commitment to global health runs deep—she regularly volunteers on international medical trips to help build sustainable care infrastructure in underserved communities. Before entering academia, Dr. Bogle spent a decade in regional and national leadership roles with CVS Health/MinuteClinic, shaping clinical operations and supporting the growth of the NP workforce. She has since secured nearly $6 million in HRSA funding to strengthen nursing education and expand care access for vulnerable populations. A Fellow of the American Association of Nurse Practitioners, she teaches across undergraduate and graduate programs, with particular focus on DNP education, health policy, and health promotion. Dr. Bogle earned her BSN from the University of Illinois, MSN (FNP/ACNP) from Vanderbilt University, DNP from UT Chattanooga, MPH in 2022, and a post‑master’s PMHNP certificate in 2023.

David Buxton

David Buxton, MD -- Co-Investigator

Dr. Buxton is Chair of Supportive Care Medicine at Moffitt Cancer Center where he oversees Palliative Medicine, Behavioral Health, and Integrative Medicine. He completed Medical School at Virginia Commonwealth University, adult psychiatry residency at Brown University, Child & Adolescent fellowship at Harvard MGH / McLean, and Palliative Medicine & Hospice fellowship at Harvard MGH-Brigham / DFCI. Dr. Buxton held previous leadership positions as the Palliative Medical Director of HCA CJW Medical and Executive Medical Director of Palliative Medicine for Adventhealth – Central Florida Division. He has been noted to have a unique expertise in finding ways to allow systems to be more efficient via improving communication through an open dialogue of 'unmentionables' in healthcare. His research interest focuses on PTSD in cancer patients and Ketamine Assisted Psychotherapy.

Deborah Silva

Deborah Silva -- Clinical Research Associate

Deborah Silva is a Clinical Research Associate in the College of Nursing's Office of Research. She has a Bachelor’s Degree in Counseling, a graduate certificate in Positive Behavior Support, and a Master’s Degree in Child and Adolescent Behavioral Health (specializing in Developmental Disabilities). She worked in pediatrics for 23 years and is currently working with young adults. She has extensive experience working on grant-funded projects and with data management. She ensures study protocols are followed on time and completed within budget. Organized and thorough, she focuses on streamlining procedures, problem-solving, and implementing innovative participant engagement strategies that enhance study compliance and improve data collection efficiency. She is passionate about engaging with people and making an impact on the community. She has lived in 5 different states & 1 foreign country and enjoys travelling internationally every year.

Autumn Mreczko

Autumn Mreczko -- Project Manager

Autumn is a project manager in the College of Nursing's Office of Research with 15 years of combined experience in project management and research support. She is committed to improving health resources, quality of life, and outcomes while advancing research initiatives that have a meaningful impact on healthcare systems.

Christina Hersh

Christina Hersh -- Graduate Research Assistant

Christina is a PhD student in the College of Nursing, dedicated to advancing cardio-oncology care by investigating patient-reported outcomes among breast cancer survivors with cardiotoxicity. As a graduate research assistant in the RAINBO lab, she supports its mission to enhance quality of life during and after cancer.

Undergraduate Research Assistants

  • Valerie Vargas Ardila Valerie Vargas Ardila
    Valerie Vargas Ardila
    Valerie is a senior majoring in Biology with a minor in Public Health in the pre-med track with the goal of becoming a pediatrician.
  • Aishwarya Aggarwal Aishwarya Aggarwal
    Aishwarya Aggarwal
    Valerie is a senior majoring in Biology with a minor in Public Health in the pre-med track with the goal of becoming a pediatrician.
  • Serene Abulhaija Serene Abulhaija
    Serene Abulhaija
    Serene is a pre-med honors student at USF, dual majoring in Biomedical Sciences and Psychology with the goal of becoming a psychiatrist.

Volunteers

  • Daniella Currie   
  • Faris Jabbar
  • Jenny Nguyen
  • Maeher Sukhija
  • The RAINBO Lab welcomes new student volunteers, Daniella Currie, Faris Jabbar, Jenny Nguyen, and Maeher Sukhija!

    Thank you to our former lab members – Maria Eduarda Souza Ribas, Anasimone Nagib, Jemima Morgan, Danielle Abukhalaf, Kenley Clark, and Berrin McFadden for your dedication to our work. 

  • CRCI REALITY: We have an open study of cancer-related cognitive impairment using real-time assessments in young adult cancer survivors. In this study, we ask individuals 18-30 years old who were diagnosed with cancer age 13-30 to complete surveys and brain games on their cell phone several times per day for up to 10 days. We will also ask them to complete two online surveys, and a computer-based cognitive assessment.

    Click here to participate in the CRCI Reality Study

    GUTSY CRCI: We have an optional add-on to the CRCI REALITY study for participants who are interested in helping us learn more about the potential connection between cognitive functioning and the gut microbiome.

  • Tometich DB, Hersh C, Maconi ML, Fulton HJ, Martinez Tyson D, Zambrano K, Hasan S, Welniak T, Rodriguez Y, Bryant C, Gudenkauf LM, Li X, Reed DR, Oswald LB, Galligan A, Small BJ, Jim HSL. "It Was a Downward Spiral": A Qualitative Study of Young Adult Cancer Survivors' Experiences with Cognitive and Mental Health. Cancers (Basel). 2024 Nov 13;16(22). doi: 10.3390/cancers16223819. PubMed PMID: 39594774; PubMed Central PMCID: PMC11592372.

    Tometich DB, Geiss C, Maconi ML, Chavez M, Hoogland AI, Li X, Nieves-Lopez A, Rodriguez Y, Bryant C, Brohl AS, Eroglu Z, Markowitz J, Tarhini AA, Hwu P, Khushalani NI, Jim HSL. Patient reported outcomes and patient experiences of immune checkpoint modulators for advanced or recurrent melanoma: a mixed methods study. Support Care Cancer. 2024 May 6;32(6):330. doi: 10.1007/s00520-024-08538-8. PubMed PMID: 38709312; PubMed Central PMCID: PMC11249036.

    Tometich DB, Welniak T, Gudenkauf L, Maconi ML, Fulton HJ, Martinez Tyson D, Zambrano K, Hasan S, Rodriguez Y, Bryant C, Li X, Reed DR, Oswald LB, Galligan A, Small BJ, Jim HSL. "I couldn't connect the wires in my brain." Young adult cancer survivors' experience with cognitive functioning. Psychooncology. 2024 Mar;33(3):e6309. doi: 10.1002/pon.6309. PubMed PMID: 38420860; PubMed Central PMCID: PMC11249037.

    Tometich DB, Hoogland AI, Small BJ, Janelsins MC, Bryant C, Rodriguez Y, Gonzalez BD, Li X, Bulls HW, James BW, Arboleda B, Colon-Echevarria C, Townsend MK, Tworoger SS, Rodriguez P, Oswald LB, Bower JE, Apte SM, Wenham RM, Chon HS, Shahzad MM, Jim HSL. Relationships among Inflammatory Biomarkers and Objectively Assessed Physical Activity and Sleep during and after Chemotherapy for Gynecologic Malignancies. Cancers (Basel). 2023 Jul 30;15(15). doi: 10.3390/cancers15153882. PubMed PMID: 37568698; PubMed Central PMCID: PMC10416903.

    Tometich DB, Mosher CE, Cyders M, McDonald BC, Saykin AJ, Small BJ, Zhai W, Zhou X, Jim HSL, Jacobsen P, Ahles TA, Root JC, Graham D, Patel SK, Mandelblatt J. An Examination of the Longitudinal Relationship Between Cognitive Function and Physical Activity Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study. Ann Behav Med. 2023 Apr 5;57(3):237-248. doi: 10.1093/abm/kaac048. PubMed PMID: 36356044; PubMed Central PMCID: PMC10074030.

    Tometich DB, Hyland KA, Soliman H, Jim HSL, Oswald L. Living with Metastatic Cancer: A Roadmap for Future Research. Cancers (Basel). 2020 Dec 8;12(12). doi: 10.3390/cancers12123684. Review. PubMed PMID: 33302472; PubMed Central PMCID: PMC7763639.

    Tometich DB, Small BJ, Carroll JE, Zhai W, Luta G, Zhou X, Kobayashi LC, Ahles T, Saykin AJ, Clapp JD, Jim HSL, Jacobsen PB, Hurria A, Graham D, McDonald BC, Denduluri N, Extermann M, Isaacs C, Dilawari A, Root J, Rini C, Mandelblatt JS. Pretreatment Psychoneurological Symptoms and Their Association With Longitudinal Cognitive Function and Quality of Life in Older Breast Cancer Survivors. J Pain Symptom Manage. 2019 Mar;57(3):596-606. doi: 10.1016/j.jpainsymman.2018.11.015. Epub 2018 Nov 23. PubMed PMID: 30472317; PubMed Central PMCID: PMC6382533.

    Tometich DB, Mosher CE, Hirsh AT, Rand KL, Johns SA, Matthias MS, Outcalt SD, Schneider BP, Mina L, Storniolo AMV, Newton EV, Miller KD. Metastatic breast cancer patients' expectations and priorities for symptom improvement. Support Care Cancer. 2018 Nov;26(11):3781-3788. doi: 10.1007/s00520-018-4244-8. Epub 2018 May 7. PubMed PMID: 29736866; PubMed Central PMCID: PMC6221997.

    For a full list of Dr. Tometich’s publications, visit https://www.ncbi.nlm.nih.gov/myncbi/danielle.tometich.1/bibliography/public/

  • Dr. Tometich can be reached at dbtometich@usf.edu

    • Not currently accepting applications for a full-time research coordinator.

    • Not currently accepting applications for graduate student research assistants.

    • Availability for undergraduate student research assistants starting in Fall 2026. Please inquire in June - July 2026.