Molecular Pharmacology and Physiology
MPP research projects in Neuroscience investigates central and peripheral nerve function, dysfunction and survival. Current projects include:
- Investigating pathological signaling in neurological disorders including amyloidopathies and tauopathies such as Alzheimer’s Disease.
- Targeting the vasculature/microenvironment to reduce neuroinflammation and neurodegeneration in neurodegenerative diseases.
- Linking vascular dysfunction to neuronal and glial injury in stroke.
- Studying the mechanisms underlying visceral pain from the esophagus – identifying the specific types of sensory nerves involved, their connectivity with CNS networks, and their activation by acid and other irritants associated with esophageal pain and heartburn.
- Determining the role of ligand-gated ion channel receptors in the tuning the signal transmission within the CNS, and how structurally diverse general anesthetics modulate the function of these ion channels.