Molecular Pharmacology and Physiology

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Recent Publications

β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates.

Woo JA, et al. Proc Natl Acad Sci U S A. 2020.

Evidence of functional ryanodine receptors in rat mesenteric collecting lymphatic vessels

Jo M, Trujillo AN, Yang Y, Breslin JW. Am J Physiol Heart Circ Physiol. 2019. 

Proinflammatory Mediators, IL (Interleukin)-1β, TNF (Tumor Necrosis Factor) α, and Thrombin Directly Induce Capillary Tube Regression.

Koller GM, Schafer C, Kemp SS, Aguera KN, Lin PK, Forgy JC, Griffin CT, Davis GE. Arterioscler Thromb Vasc Biol. 2020.

Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function.

Thomas L, Xue J, Murali SK, Fenton RA, Dominguez Rieg JA, Rieg T. J Am Soc Nephrol. 2019.

Robust RBM3 and β-klotho expression in developing neurons in the human brain.

Jackson TC, Janesko-Feldman K, Carlson SW, Kotermanski SE, Kochanek PM. J Cereb Blood Flow Metab. 2019.

The voltage-gated sodium channel NaV1.8 blocker A-803467 inhibits cough in the guinea pig.

Brozmanova M, Svajdova S, Pavelkova N, Muroi Y, Undem BJ, Kollarik M. Respir Physiol Neurobiol. 2019.

Aging Impairs Renal Autoregulation in Mice.

Wei J, Zhu J, Zhang J, Jiang S, Qu L, Wang L, Buggs J, Tan X, Cheng F, Liu R. Hypertension. 2020.

Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion.

Dodge A, Peters MM, Greene HE, Dietrick C, Botelho R, Chung D, Willman J, Nenninger AW, Ciarlone S, Kamath SG, Houdek P, Sumová A, Anderson AE, Dindot SV, Berg EL, O'Geen H, Segal DJ, Silverman JL, Weeber EJ, Nash KR. Autism Res. 2020.

VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance.

Yang Y, Cha B, Motawe ZY, Srinivasan RS, Scallan JP. Cell Rep. 2019.

Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously hypertensive rat.

Hooper JS, Stanford KR, Alencar PA, Alves NG, Breslin JW, Dean JB, Morris KF, Taylor-Clark TE. J Physiol. 2019.

Heparan sulfate inhibits transforming growth factor β signaling and functions in cis and in trans to regulate prostate stem/progenitor cell activities.

Rai S, Alsaidan OA, Yang H, Cai H, Wang L. Glycobiology. 2019.

MPP News:

MicroRNA regulates cell differentiation process vital to placenta growth in early pregnancy

USF Health researchers applied CRISPR technology to study the very large human non-protein coding gene expressed only in placenta, stem cells [...]

Dr. Totary-Jain

Beta-arrestin-2 increases neurotoxic tau driving frontotemporal dementia

University of South Florida study suggests a new approach to inhibit the buildup of brain-damaging tau tangles associated with FTLD, Alzheimer’s disease [...]

A beta-arrestin-2 oligomer (foreground) shown within a nerve cell (background).

New study identifies inflammatory molecules controlling capillary loss common in many diseases

Using an innovative cellular model, the USF Health-led study also discovers drug combinations to prevent degeneration of these tiniest blood vessels. Many diseases arise from abnormalities in our capillaries [...]

Endothelial cell-lined tubes