Molecular Pharmacology and Physiology

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Recent Publications 

Sigma-1 receptor activation-induced glycolytic ATP production and endothelial barrier enhancement.

Motawe ZY, Farsaei F, Abdelmaboud SS, Cuevas J, Breslin JW. Microcirculation. 2020 Apr.

Mapping of Sensory Nerve Subsets within the Vagal Ganglia and the Brainstem Using Reporter Mice for Pirt, TRPV1, 5-HT3, and Tac1 Expression.

Kim SH, Hadley SH, Maddison M, Patil M, Cha B, Kollarik M, Taylor-Clark TE.eNeuro. 2020 Apr.

Ketone Bodies Attenuate Wasting in Models of Atrophy.

Koutnik AP, Poff AM, Ward NP, DeBlasi JM, Soliven MA, Romero MA, Roberson PA, Fox CD, Roberts MD, D'Agostino DP.J Cachexia Sarcopenia Muscle. 2020 Apr.

An inducible intestinal epithelial cell-specific NHE3 knockout mouse model mimicking congenital sodium diarrhea.

Xue J, Thomas L, Tahmasbi M, Valdez A, Dominguez Rieg JA, Fenton RA, Rieg T.Clin Sci (Lond). 2020 Apr.

Identification of novel targets of RBM5 in the healthy and injured brain.

Jackson TC, Janesko-Feldman K, Gorse K, Vagni VA, Jackson EK, Kochanek PM.Neuroscience. 2020 Apr.

β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates.

Woo JA, et al. Proc Natl Acad Sci U S A. 2020 March. 

Structural Determinants Mediating Tertiapin Block of Neuronal Kir3.2 Channels.

Patel D, Kuyucak S, Doupnik CA. Biochemistry. 2020 Feb.

AKT2 maintains brain endothelial claudin-5 expression and selective activation of IR/AKT2/FOXO1-signaling reverses barrier dysfunction.

Beard RS Jr, Hoettels BA, Meegan JE, Wertz TS, Cha BJ, Yang X, Oxford JT, Wu MH, Yuan SY.J Cereb Blood Flow Metab. 2020 Feb.

New Mechanism for the Sex Differences in Salt-Sensitive Hypertension: The Role of Macula Densa NOS1β-Mediated Tubuloglomerular Feedback.

Zhang J, Zhu J, Wei J, Jiang S, Xu L, Qu L, Yang K, Wang L, Buggs J, Cheng F, Tan X, Liu R.Hypertension. 2020 Feb.

Proinflammatory Mediators, IL (Interleukin)-1β, TNF (Tumor Necrosis Factor) α, and Thrombin Directly Induce Capillary Tube Regression.

Koller GM, Schafer C, Kemp SS, Aguera KN, Lin PK, Forgy JC, Griffin CT, Davis GE. Arterioscler Thromb Vasc Biol. 2020 Feb. 

MPP News:

MicroRNA regulates cell differentiation process vital to placenta growth in early pregnancy

USF Health researchers applied CRISPR technology to study the very large human non-protein coding gene expressed only in placenta, stem cells [...]

Dr. Totary-Jain

Beta-arrestin-2 increases neurotoxic tau driving frontotemporal dementia

University of South Florida study suggests a new approach to inhibit the buildup of brain-damaging tau tangles associated with FTLD, Alzheimer’s disease [...]

A beta-arrestin-2 oligomer (foreground) shown within a nerve cell (background).

New study identifies inflammatory molecules controlling capillary loss common in many diseases

Using an innovative cellular model, the USF Health-led study also discovers drug combinations to prevent degeneration of these tiniest blood vessels. Many diseases arise from abnormalities in our capillaries [...]

Endothelial cell-lined tubes