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Jinwal Lab

Research

Selected Publications

Ram N, Peak SL, Perez AR, Jinwal UK. Implications of Withaferin A in neurological disorders. Neural Regen Res. 2021 Feb;16(2):304-305.

Peak SL, Gracia L, Lora G, Jinwal UK. Hsp90-interacting Co-chaperones and their Family Proteins in Tau Regulation: Introducing a Novel Role for Cdc37L1. Neuroscience. 2021 Jan 15;453:312-323.

Jinwal, U,K., Sutariya, V.B. (2020) Preparation and Characterization of Methylene Blue Nanoparticles for Alzheimer's Disease and Other Tauopathies. United States Patent Office (USPTO) # 10,765,755.

Gracia L, Lora G, Blair LJ, Jinwal UK* (2019) Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases. Frontiers Neuroscience. 13:1263. doi: 10.3389/fnins.2019.01263.

Narayan, M., Kirouac, L., Chaput, D., Stevens, S., Padmanabhan, J., Jinwal, U.K (2016) Identification of Novel Cdc37 Interacting Proteins and Pathways in Human Alzheimer’s Disease Brain Tissue using Mass Spectrometry. Journal of Data Mining in Genomics & Proteomics, 7:193. doi: 10.4172/2153-0602.1000193.

Narayan M, Peralta DA, Gibson C, Zitnyar A, Jinwal UK. An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug. J Biotechnol. 2015 Aug 10;207:34-8.

Jinwal, U.K., Trotter, J.H., Abisambra, J.F., Vestal, G.D., Koren, J. III, Lawson, L.Y., Vestal, G.D., O’Leary, J.C., Johnson, A.G., Jin, Y., Jones, J.R, Li, Q., Weeber, E.J. and Dickey, C.A. (2011) The Hsp90 kinase co-chaperone Cdc37 regulates tau stability. The Journal of Biological Chemistry, 286, 16976-83.

Jinwal, U.K., Koren, J. III, Borysov, S.I., Schmid, A.B., Abisambra, J.F., Blair, L.J., Johnson, A.G., Jones, J.R, Shults, C., O’Leary, J. III, Jin, Y., Buchner, J., Cox, M.B., and Dickey, C.A. (2010) The Hsp90 co-chaperone, FKBP51, increases tau stability and polymerizes microtubules. The Journal of Neuroscience, 30, 591-599.

Dickey, C.A., Koren, J., Zhang, Y.J., Xu, Y.F., Jinwal, U.K., Birnbaum, M.J., Monks, B., Sun, M., Cheng, J.Q., Patterson, C., Bailey, R.M., Dunmore, J., Soresh, S., Leon, C., Morgan, D., Petrucelli, L. (2008) Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105, 3622-3627.