Cardiovascular Biology in the Medical Sciences PhD Program is under the broad heading of cardiovascular research, with an emphasis on vascular biology. A concentration in cardiovascular biology provides training in such diverse fields as gene regulation and differentiation in smooth muscle, molecular biology of smooth and cardiac muscle, receptor function and signal transduction in smooth muscle and endothelial cells, matrix, and adhesion molecules in endothelial cell function, cell-cell communication, vascular development and inflammation, angiogenesis, and remodeling. Training includes a unique interdisciplinary blend of didactic coursework, journal clubs, seminar series, as well as significant research experience. The interdisciplinary structure permits considerable flexibility in training; each students’ training is tailored to meet individual requirements.

Lab Spotlight

Concentration Spotlights

News

• Age-related decline in two sirtuin enzymes alters mitochondrial dynamics, weakens cardiac contractions
• Preclinical study defines spleen-heart connection in cardiac repair
• Blocking lipoxygenase leads to impaired cardiac repair in acute heart failure

Recent Publications

• Bowers SLK, Kemp SS, Aguera KN, Koller GM, Forgy JC, Davis GE. Defining an Upstream VEGF (Vascular Endothelial Growth Factor) Priming Signature for Downstream Factor-Induced Endothelial Cell-Pericyte Tube Network Coassembly. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2891-2909. doi: 10.1161/ATVBAHA.120.314517. Epub 2020 Oct 22. PMID: 33086871; PMCID: PMC7939123.
  
  
• Schafer CM, Gurley JM, Kurylowicz K, Lin PK, Chen W, Elliott MH, Davis GE, Bhatti F, Griffin CT. An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26494-26502. doi: 10.1073/pnas.2015980117. Epub 2020 Oct 5. PMID: 33020273; PMCID: PMC7584886.