Welcome to the USF Health
- Cancer-treatment induced cardiotoxicity is the leading cause of the mortality in more than 15.5 million cancer survivors. Moreover, the cardiotoxicity is the reason cancer patients could not continue receiving treatment. Research of my lab is focused on understanding the mechanism of cancer-treatment related cardiotoxicity through integrated omics-based approach and validating nano-scale platform treatment strategies to mitigate cardiotoxocity for cancer patients and survivors. My laboratory provides a multidisciplinary basic and applied research environment and training venue with a translational emphasis. Specific research focuses include:
- 1. Mitigate cancer-treatment related vascular damage with anti-thrombotic interventions.
- 2. Target the Nox2/4-oxidative stress axis for predicting and alleviating cardiomyocyte toxicity caused by anthracyclines.
- 3. Target the inflammation signaling pathways for predicting and alleviating cardiotoxicity caused by immune checkpoint inhibitors.
Congratulations to Mr. John Lockhart!
We would like to congratulate Mr. John Lockhart, who has been awarded with the 2019 Keystone Symposia Scholarship and has also been invited to give a short talk about his submitted abstract entitled, “Effective Delivery of Therapeutic mRNA using Peptide-Based Nanoparticles.” This work was done in collaboration with the laboratories of Dr. Hua Pan and Dr. Samuel Wickline using a novel-based peptide nanoparticle system for oligonucleotide delivery. Mr. Lockhart is a Ph.D. candidate being mentored, by Dr. Hana Totary-Jain, who is an Assistant Professor in the Department of Molecular Pharmacology & Physiology. The Keystone Symposia will take place on April 7 – 10, 2019 in Steamboat Springs, Colorado. We are very proud of Mr. Lockhart’s accomplishments - Congratulations!