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Professor, College of Medicine Family Medicine
- Over the last 10 years my lab's emphasis has been on elucidating molecular mechanisms involved in the process of neuronal and glial injury following ischemia in the central nervous system. My research has sought to identify key components of the injury that can serve as biomarkers for disease progression and/or as target for therapeutics. We actively collaborate with experts from other disciplines in our efforts to develop new molecular entities for stroke therapeutics. Some of my current research interests are:
- 1. Small molecule design and development targeting sigma receptors for stroke therapy at delayed time points.
- 2. Exploring overlapping molecular mechanisms involved in expansion of the ischemic core in large-vessel stroke and infarct coalesces in lacunar infarcts.
- 3. Characterizing a novel endogenous agonist of acid-sensing ion channels that may be involved in physiological and pathophysiological function of this channel in the brain.
Associate Professor, College of Medicine Molecular Pharmacology & Physiology
- The main areas of Dr. Rieg's research interests are the physiology and pathophysiology of the kidney and intestine. He successfully contributed to various projects related to aspects of kidney and intestinal function using a variety of genetically modified models. His research focuses on the characterization of channels, transporters, receptors and signaling molecules in the physiology and pathophysiology of the kidney including arterial hypertension. His work is instrumental in determining the physiology of sodium-glucose cotransporters and the pharmacology of SGLT2 inhibitors. Methods used to study aspects of the kidney function include: metabolic balance studies, clearance and micropuncture studies in anesthetized mice as well as measurement of glomerular filtration rate in awake mice using single-bolus technique and a two-compartment kinetic model.
Dr. Bibhu Mohanty - Tips on Heart Health
A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans
Plot of the odds of developing idiopathic dilated cardiomyopathy (a form of heart failure) from various genetic variations on chromosome 2. A variation in a calcium channel subunit (CACNB4) showed the greatest risk for developing the disease. The population is African-American, and the results are from a recent study published from the Heart Institute.
Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution<br>
Infantile hemangiomas (IHs) are the most common benign vascular neoplasms of infancy, characterized by a rapid growth phase followed by a spontaneous involution, or triggered by propranolol treatment by poorly understood mechanisms. LIN28/let-7 axis plays a central role in the regulation of stem cell self-renewal and tumorigenesis. However, the role of LIN28B/let-7 signaling in IH pathogenesis has not yet been elucidated.
USF Health Institute News
The USF Health Heart Institute recently hosted its inaugural scientific conference, marking another milestone in the young Institute’s short history and setting a standard for future collaborative work that seeks to halt cardiovascular disease. The 1st Annual Scientific Colloquium was held Sept. 24 … [read more]
Michael Fradley, MD, had finished medical school. He’d completed training in internal medicine and cardiology. He decided to pursue further training in electrophysiology, and began observing a substantial number of cancer patients were experiencing abnormal heart rhythms. Then, in the midst of h … [read more]
In the laboratory and the clinic, Dr. Thomas McDonald focuses on inherited heart diseases that can lead to potentially deadly heart rhythm disturbances //www.youtube.com/watch?v=0mdWzfFOqHY Sudden cardiac death most often makes the news when athletes in peak physical condition collapse and die whil … [read more]