Welcome to the USF Health
- Over the last 10 years my lab's emphasis has been on elucidating molecular mechanisms involved in the process of neuronal and glial injury following ischemia in the central nervous system. My research has sought to identify key components of the injury that can serve as biomarkers for disease progression and/or as target for therapeutics. We actively collaborate with experts from other disciplines in our efforts to develop new molecular entities for stroke therapeutics. Some of my current research interests are:
- 1. Small molecule design and development targeting sigma receptors for stroke therapy at delayed time points.
- 2. Exploring overlapping molecular mechanisms involved in expansion of the ischemic core in large-vessel stroke and infarct coalesces in lacunar infarcts.
- 3. Characterizing a novel endogenous agonist of acid-sensing ion channels that may be involved in physiological and pathophysiological function of this channel in the brain.
- The main areas of Dr. Rieg's research interests are the physiology and pathophysiology of the kidney and intestine. He successfully contributed to various projects related to aspects of kidney and intestinal function using a variety of genetically modified models. His research focuses on the characterization of channels, transporters, receptors and signaling molecules in the physiology and pathophysiology of the kidney including arterial hypertension. His work is instrumental in determining the physiology of sodium-glucose cotransporters and the pharmacology of SGLT2 inhibitors. Methods used to study aspects of the kidney function include: metabolic balance studies, clearance and micropuncture studies in anesthetized mice as well as measurement of glomerular filtration rate in awake mice using single-bolus technique and a two-compartment kinetic model.
Congratulations to Mr. John Lockhart!
We would like to congratulate Mr. John Lockhart, who has been awarded with the 2019 Keystone Symposia Scholarship and has also been invited to give a short talk about his submitted abstract entitled, “Effective Delivery of Therapeutic mRNA using Peptide-Based Nanoparticles.” This work was done in collaboration with the laboratories of Dr. Hua Pan and Dr. Samuel Wickline using a novel-based peptide nanoparticle system for oligonucleotide delivery. Mr. Lockhart is a Ph.D. candidate being mentored, by Dr. Hana Totary-Jain, who is an Assistant Professor in the Department of Molecular Pharmacology & Physiology. The Keystone Symposia will take place on April 7 – 10, 2019 in Steamboat Springs, Colorado. We are very proud of Mr. Lockhart’s accomplishments - Congratulations!