Welcome to the USF Health
Heart Institute
Featured Faculty
- Cancer-treatment induced cardiotoxicity is the leading cause of the mortality in more than 15.5 million cancer survivors. Moreover, the cardiotoxicity is the reason cancer patients could not continue receiving treatment. Research of my lab is focused on understanding the mechanism of cancer-treatment related cardiotoxicity through integrated omics-based approach and validating nano-scale platform treatment strategies to mitigate cardiotoxocity for cancer patients and survivors. My laboratory provides a multidisciplinary basic and applied research environment and training venue with a translational emphasis. Specific research focuses include:
- 1. Mitigate cancer-treatment related vascular damage with anti-thrombotic interventions.
- 2. Target the Nox2/4-oxidative stress axis for predicting and alleviating cardiomyocyte toxicity caused by anthracyclines.
- 3. Target the inflammation signaling pathways for predicting and alleviating cardiotoxicity caused by immune checkpoint inhibitors.
Congratulations to Mr. John Lockhart!
We would like to congratulate Mr. John Lockhart, who has been awarded with the 2019 Keystone Symposia Scholarship and has also been invited to give a short talk about his submitted abstract entitled, “Effective Delivery of Therapeutic mRNA using Peptide-Based Nanoparticles.” This work was done in collaboration with the laboratories of Dr. Hua Pan and Dr. Samuel Wickline using a novel-based peptide nanoparticle system for oligonucleotide delivery. Mr. Lockhart is a Ph.D. candidate being mentored, by Dr. Hana Totary-Jain, who is an Assistant Professor in the Department of Molecular Pharmacology & Physiology. The Keystone Symposia will take place on April 7 – 10, 2019 in Steamboat Springs, Colorado. We are very proud of Mr. Lockhart’s accomplishments - Congratulations!
Dr. Bibhu Mohanty - Tips on Heart Health
Articles
A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans
Plot of the odds of developing idiopathic dilated cardiomyopathy (a form of heart failure) from various genetic variations on chromosome 2. A variation in a calcium channel subunit (CACNB4) showed the greatest risk for developing the disease. The population is African-American, and the results are from a recent study published from the Heart Institute.
Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution<br>
Infantile hemangiomas (IHs) are the most common benign vascular neoplasms of infancy, characterized by a rapid growth phase followed by a spontaneous involution, or triggered by propranolol treatment by poorly understood mechanisms. LIN28/let-7 axis plays a central role in the regulation of stem cell self-renewal and tumorigenesis. However, the role of LIN28B/let-7 signaling in IH pathogenesis has not yet been elucidated.
USF Health Institute News
7/3/2019
USF’s Microbiome Research initiative continues to gain momentum as USF Health and Moffitt Cancer Center faculty met recently to begin exploring how both institutions might best use their collective resources to advance in the emerging, complex field.
A panel of faculty and staff from USF Health and …
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6/18/2019
The USF Health study, using a rat model for high blood pressure, helps explain the different nerve-induced physiological response to air pollution in patients with preexisting cardiovascular disease
Numerous studies have linked air pollution with cardiovascular disease, including evidence suggesting …
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6/7/2019
The latest neuroscientist recruits will help USF Health accelerate new discoveries in Alzheimer’s disease and other neurological disorders
The USF Health Neuroscience Center brings together scientists and physicians to investigate the complexities of the brain and its impact on human health and beh …
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