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Assistant Professor Biomedical, College of Medicine Cardiology
- Cancer-treatment induced cardiotoxicity is the leading cause of the mortality in more than 15.5 million cancer survivors. Moreover, the cardiotoxicity is the reason cancer patients could not continue receiving treatment. Research of my lab is focused on understanding the mechanism of cancer-treatment related cardiotoxicity through integrated omics-based approach and validating nano-scale platform treatment strategies to mitigate cardiotoxocity for cancer patients and survivors. My laboratory provides a multidisciplinary basic and applied research environment and training venue with a translational emphasis. Specific research focuses include:
- 1. Mitigate cancer-treatment related vascular damage with anti-thrombotic interventions.
- 2. Target the Nox2/4-oxidative stress axis for predicting and alleviating cardiomyocyte toxicity caused by anthracyclines.
- 3. Target the inflammation signaling pathways for predicting and alleviating cardiotoxicity caused by immune checkpoint inhibitors.
Assistant Professor, College of Medicine Molecular Pharmacology & Physiology
- My laboratory performs research in the area of lymphatic vascular biology to gain insight into how loss of lymphatic vessel function leads to disease. Specifically, we use a unique combination of genetic and physiologic approaches to quantify lymphatic vascular permeability, which allows us to assess fluid and solute transport across the lymphatic vessel wall. Diseases associated with leaky lymphatic vessels include obesity, type 2 diabetes, hypercholesterolemia, lymphedema, and infection. Our research is multidisciplinary as we routinely collaborate with investigators from physiology, immunology, and developmental biology areas. Some current areas of interest are:
- 1)The physical pathways and molecular regulators that restrict solute and fluid loss across the lymphatic vessel wall, preventing edema.
- 2)The role of lymphatic vascular permeability in immune cell trafficking to the lymph node.
Dr. Bibhu Mohanty - Tips on Heart Health
A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans
Plot of the odds of developing idiopathic dilated cardiomyopathy (a form of heart failure) from various genetic variations on chromosome 2. A variation in a calcium channel subunit (CACNB4) showed the greatest risk for developing the disease. The population is African-American, and the results are from a recent study published from the Heart Institute.
Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution<br>
Infantile hemangiomas (IHs) are the most common benign vascular neoplasms of infancy, characterized by a rapid growth phase followed by a spontaneous involution, or triggered by propranolol treatment by poorly understood mechanisms. LIN28/let-7 axis plays a central role in the regulation of stem cell self-renewal and tumorigenesis. However, the role of LIN28B/let-7 signaling in IH pathogenesis has not yet been elucidated.
USF Health Institute News
The partnership between USF Health Morsani College of Medicine and the College of Engineering can help spur new technologies, devices and processes to improve health care and reduce costs //www.youtube.com/watch?v=1_M2KKqPYcE A rare joint program between the USF College of Engineering and USF Healt … [read more]
Cardiologists could and should take more action in guiding their patients to interventions aimed at delaying, and even preventing, diabetes, USF Health faculty proposed last month in a review published in the American Journal of Cardiology. “We propose cardiologists can play a key role in preventin … [read more]
Dr. Christian Bréchot will help elevate biomedical and health-related areas of research excellence to the international level The former head of the world-renowned Pasteur Institute in Paris has joined USF Health to help university leaders strengthen biomedical and health-related areas of research e … [read more]