USF Heart Institute


Congratulations to Dr. Wang!

Dr. Zhigao Wang's grant titled “Regulation of cell death and disease by a novel membrane protein MADMAN” was awarded by the National Institute of General Medical Sciences (NIGMS) on 9/1/2022. Dr Wang was also selected as a Review Editor on the Editorial Board of Regulated Cell Death for journal Frontiers in Cell Death.


 

Dr. Christine Klemens

Congratulations to Dr. Klemens!

Dr. Christine Klemens was awarded a highly competitive K99 grant from the NIH NHLBI section to study the role of an understudied chloride transporter, ClC-6, in renal and vascular function during hypertension. These studies will provide further mechanistic insight to the role of this protein in blood pressure regulation in normotensive and pathological conditions. Dr. Klemens received her PhD from the University of Pittsburgh and was previously a postdoctoral fellow at the Medical College of Wisconsin. She is currently a Research Associate under the mentorship of Dr. Alexander Staruschenko, the current director of the Hypertension and Kidney Research Center, part of the USF School of Medicine Heart Institute. 


 

Congratulations to Dr. Wang!

Dr. DaZhi Wang was invited to give a seminar at the Stanford Cardiovascular Institute, Stanford University, on Jan 18, 2022. The title of his presentation was "Molecular Regulation of Cardiac Function, Regeneration and Disease." This archived talk is available for viewing here: https://med.stanford.edu/cvi/events/frontiers-in-cv-science/seminar-videos-2022.html.

Da-Zhi Wang

Featured Faculty

Da-Zhi Wang

Da-Zhi Wang, PhD

Professor, USF Health Heart Institute
Thomas McDonald, MD

Thomas McDonald, MD

Professor, USF Health Heart Institute

Stephen Liggett, MD

Stephen Liggett, MD

Vice Dean for Research, Morsani College of Medicine
Associate Vice President for Research, USF Health
Professor of Internal Medicine

Ganesh Halade, PhD

Ganesh Halade, PhD

Associate Professor, USF Health Heart Institute


Dr. Bibhu Mohanty - Tips on Heart Health
Dr. Bibhu Mohanty - Tips on Heart Health
Surface TAS2R14-WT expression with DPD treatment in HEK293T cells
Surface TAS2R14-WT expression with DPD treatment in HEK293T cells

Articles

Anti-atherosclerotic therapies: Milestones, challenges, and emerging innovations

In patients with acute coronary syndromes, surgical revascularization with percutaneous coronary intervention has greatly reduced mortality rates. However, stent thrombosis and neo-atherosclerosis have emerged as major safety concerns of drug eluting stents due to delayed re-endothelialization. This review summarizes the major milestones, strengths, and limitations of current anti-atherosclerotic therapies. It provides an overview of the recent discoveries and emerging game-changing technologies in the fields of nanomedicine, mRNA therapeutics, and gene editing that have the potential to revolutionize CVD clinical practice by steering it toward precision medicine.

Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

Hypertension and kidney disease have been repeatedly associated with genomic variants and alterations of lysine metabolism. Here, we combined stable isotope labeling with untargeted metabolomics to investigate lysine’s metabolic fate in vivo. Dietary 13C6 labeled lysine was tracked to lysine metabolites across various organs.

To read more about Accelerated Lysine Metabolism, click here

Effects of elevation of ANP and its deficiency on cardiorenal function

Atrial natriuretic peptide (ANP), encoded by Nppa, is a vasodilatory hormone that promotes salt excretion. Genome-wide association studies identified Nppa as a causative factor of blood pressure development, and in humans, ANP levels were suggested as an indicator of salt sensitivity. This study aimed to provide insights into the effects of ANP on cardiorenal function in salt-sensitive hypertension.

New Insights Into the Molecular Underpinnings of LVNC

Maturation of the vertebrate heart requires transformation of the spongy, trabeculated heart wall into a thick, dense tissue that is called the compact myocardium. Interference with this transition leads to a myocardial defect known as left ventricular noncompaction (LVNC).

USF Health Institute News

9/21/2022
The USF Health Morsani College of Medicine Academy of Distinguished Educators class of 2022 (Left to right): Eduardo Gonzalez, MD, FAAFP; Andreas Seyfang, PhD; John Armstrong, MD, FACS; Marzenna Wiranowska, PhD, MS; Susan Pross, PhD. The USF Health Morsani College of Medicine (MCOM) recently celebra … [read more]
9/6/2022
USF Health doctors are among the best and listed as such in the Top Doctor® list by Castle Connolly. The list, released earlier this year, includes over 400 local physicians among 55 medical specialties – 82 of them are with USF Health. USF Health Neurologist Dr. Theresa Zesiewicz. For more than 25 … [read more]
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