Current Research

Basic Research Heart Institute Faculty Grants – Overview 

Jerome Breslin, Ph.D.

NIH/NHLBI R01HL098215
Regulatory Mechanisms for Resolution of Inflammatory Microvascular Leakage
Role: PI

NIH/NIGMS R01GM120774
S1P-fluid therapy to reduce hemorrhagic shock & intoxication-induced injury
Role: PI

Emma Heart, Ph.D.

R01DK097847
Agency: NIH-NIDDK; role: PI; title: “Cytosolic and Plasma membrane circuitry of beta cell redox control: role in survival, oxidative defense and insulin secretion”

This grant investigates the role of plasma membrane electron transport, a novel system which transports electrons out of cells and re-oxidizes cellular reduced equivalents, in the cellular metabolism and insulin secretion from pancreatic beta cells.

Arthur Labovitz, M.D.

R0161311002
“Ischemia – International Study of Comparative Health Effectiveness with Medical and Invasive Approaches”
Sponsor: New York University

Stephen Liggett, M.D.

P01HL114471
“Novel Molecular Mechanisms Promote GPCR-Induced Bronchodilation in Asthma, Project 2 Airway Smooth Muscle Bitter Taste Receptors as Targets for Novel Bronchodilators”
Sponsor: Rutgers University

R01HL045967
“Molecular Peptides of B-Adrenargic Receptors in Asthma”
Sponsor: National Heart and Blood Institute

Ruisheng Liu, M.D.

R01DK099276 - Liu (PI)
Primary cilia and modulation of the renal microcirculation
The major goal of this project is to study the role of primary cilia on the macula densa regulated by the tubular flow in control of renal hemodynamics and salt-water balance.
Role: PI

R01DK098582 - Liu (PI)
Tubuloglomerular feedback and salt-sensitive hypertension
The major goals of this project are to study the expression and role of splice variants of NOS1 expressed in the macula densa in control of tubuloglomerular feedback, salt-water balance and blood pressure.
Role: PI

Ronald Magness, Ph.D.

R01HL117341
“Endothelial Function in a Model of IUGR Induced by Uterine Space Restriction”
National Heart Lung and Blood Institute

Sami Noujaim, Ph.D.

miR21HL138064
“Bioengineered Peptibodies as Antiarrhythmic Therapy in Atrial Fibrillation”
Sponsor: National Heart Lung and Blood Institute

7R01HL129136-02
“Molecular Mechanisms of Atrial Fibrillation in Aging”
Sponsor: National Institutes of Health

Timo Rieg, Ph.D.

NIH 1R01DK110621-01 (Rieg)
Role: P.I.
Role of Renal and Intestinal AC6 and NHE3 for Phosphate Homeostasis

American Physiological Society, Dean Franklin Young Investigator Award (Rieg)
Role: P.I.
Support to by equipment from DSI for physiological monitoring

Joshua Scallan, Ph.D.

5R00HL124142-04 (Scallan, PI)
NIH / NHLBI
Lymphatic Endothelial Permeability as a Regulator of Mesenteric Adipose Deposition
The goals of this project are to understand how lymphatic vessel permeability is regulated in health and whether elevatedlymphatic vessel permeability leads to pathologic accumulation of adipose tissue.

1R01HL131652-01A1 (Scallan, Consortium Leader)
NIH / NHLBI
Defining the Mechanisms of Lymphatic and Lymphovenous Valve Development
The goals of this project are to quantify the valve defects of lymphatic vessels from mice lacking genes implicated in valve morphogenesis.

Thomas Taylor-Clark, Ph.D.

R01HL119802
Principle Investigator. National Heart Lung and Blood Institute R01 “Mitochondrial reactive oxygen species induce airway sensory nerve activity”

- Additional research supplement for unrepresented minorities
16GRNT31460004
Principle Investigator. American Heart Association Grant-in-Aid “Cardiovascular disease-associated neuronal plasticity transforms pulmonary-cardiac reflexes to sympathoexcitation”.

OT2OD023854
Co-Principle Investigator. National Institutes of Health Common Fund SPARC OT2 : “Functional mapping of peripheral and central circuits for airway protection and breathing”.

Hana Totary-Jain, Ph.D.

R00 HL109133 - Totary-Jain (PI)
NIH/NHLBI
MicroRNA De-targeting: Novel Therapy for Coronary Artery Disease
The goal of this project is to develop new therapeutic approaches based on microRNA de-targeting strategies.

RO1 HL128411-01 - Totary-Jain (PI)
NIH/NHLBI
MicroRNA-Based, Cell-Selective Therapy for Coronary Artery Disease
The major goal of this project is to test the efficacy of the novel microRNA-Based, cell selective therapy in atherosclerotic rabbit models.

15PRE25850019 - Trainee: John Canfield
07/1/2015 – 06/30/2017
AHA
A microRNA Based Strategy to Treat Pulmonary Hypertension

Samuel Wickline, M.D.

R01 HL073646-12 N (Wickline)
National Institutes of Health
“Anti-inflammatory therapeutics for cardiovascular disease”
The specific aims are to: 1) Design, formulate, and evaluate targeted anti-inflammatory nanotherapies in vitro. 2) Test therapeutic formulations in vivo in a standardized ApoE -/-mouse thrombosis model. 3) Test nanoparticle combinations and multiplexed nanoparticles in vivo for synergistic efficacy.

R01 DK102691 (Wickline)
National Institutes of Health
“Prevention and Treatment of Acute Kidney Injury”
We will design and deploy new nanoparticle therapeutic agents that are active against selected inflammatory signaling pathways (e.g., NFkB, apoptosis: Bak/Bax, and thrombin/PAR-1) in unique and effective formulations that provide localized sustained release of agents (peptides, siRNA) that may be complementary and synergistic in early and advanced AKI, or even when applied as preventative measures.

R01 AR067491 (Pham/Wickline: Co-PI’s)
National Institutes of Health
“Inhibition of NF-kB with SIRNA/Peptide Nanoparticles for Arthritis Treatment”
In this proposal, we propose to develop new nanomedicines that can safely modulate the inflammation in the host and preserve joint integrity without compromising the immune system.

R21 EB019569 (Wickline/McCarthy: Co-PI’s)
National Institutes of Health
“Real Time Ultrasound Entropy-Based Quantification of Fibrofatty Liver Disease”
The major problem addressed in this proposal is the development and evaluation of a noninvasive ultrasonic diagnostic approach for mapping a set of unique and quantitative ultrasonic metrics for liver disease as well.

Daniel Yip, Ph.D.

Department of Defense Ovarian Cancer Research Program
OC 160457 Yip (PI)
“The role of mesothelial omentin in ovarian cancer progression.”
The major goals of this project are to study the how the increase expression of omentin in mesothelium of omentum suppresses the progression of ovarian cancer by using traction force microscopy, live cell subcellular calcium imaging, Electric Cell-substrate Impedance Sensing.

R01 DK098562 Liu (PI)
“Tubuloglomerular feedback and salt-sensitive hypertension.”
The major goals of this project are to study the expression and role of splice variants of NOS1 expressed in the macula densa in control of tubuloglomerular feedback, salt-water balance and blood pressure.
Role : Co-investigator

R01 DK099276 Liu (PI)
“Primary cilia and modulation of the renal microcirculation.”
The major goals of this project is to study role of primary cilia on macula densa cells on the regulation of renal blood flow autoregulation.
Role : Co-investigator

Mack Wu, M.D.

5R01HL120954-04
“Endothelial Focal Adhesions in Microvascular Barrier Dysfunction During Ischemia-Reperfusion Injury”
Sponsor: National Heart Lung and Blood Institute

Sarah Yuan, M.D. 

NIH RO1 HL070752 - “Microvascular barrier dysfunction in thermal trauma”
NIH RO1 HL126646 - “Leukocyte activation in microvascular hyperpermeability”
NIH RO1 GM097270 - “Disintegrin metalloprotease & endothelial function in sepsis”