USF Health Byrd Alzheimer’s Center and Research Institute
- University of South Florida Health neuroscientists discover a defect early in autophagy that may help develop SSH1 inhibitors to treat Alzheimer’s and other neurodegenerative diseases
at the University of South Florida Health (USF Health) Byrd
Alzheimer’s Center report for the first time that the
protein phosphatase Slingshot-1, or SSH1 for short, disrupts p62’s ability to
function as an efficient “garbage collector” and thereby impairs the disposal
of both damaged tau and mitochondria leaking toxins. In a preclinical study,
the researchers showed that SSH1’s influence in halting p62-mediated protective
clearance of tau was separate from SSH1’s role in activating cofilin, an enzyme that plays an essential part in
worsening tau pathology.
findings were published Oct. 12 in Autophagy.
- Byrd Institute welcomes new researcher
Byrd Institute welcomes Dr. Bradlee Heckmann, PhD, Assistant Professor
of Molecular Medicine and Byrd investigator. Dr. Heckmann received his PhD from
the Mayo Clinic College of Medicine and postdoctoral training from
world-renowned researcher Dr. Douglas Green at St. Jude Children’s Hospital.
Dr. Heckmann’s research focuses on the molecular and cellular mechanisms, as
well as physiological influences that govern neuroimmunity. He recently
discovered a non-canonical use of the autophagy machinery in a process called
LC3-associated endocytosis. He further identified a role for this pathway in
regulating neuroinflammation and in the prevention of amyloid deposition and
neurodegeneration in Alzheimer’s disease. His work at USF Health and the Byrd
Alzheimer’s Institute will continue to focus on understanding the non-canonical
roles of the autophagy machinery and other mechanisms in regulating
neuroinflammation. Cumulatively, Dr. Heckmann and his research program aim to
further our understanding of how our brains are protected against
neurodegeneration, and how to therapeutically target neurodegenerative
diseases, infections, cancer, and beyond.
- Byrd Investigators Dr. David Kang and Dr.
Alexa Woo spearhead a new NIH-funded research project
We are thrilled to announce the award of a $1.9
million National Institutes of Health (NIH) grant to co-PIs Dr. David Kang, PhD, and Dr. Alexa Woo, PhD. Dr.
Kang is the Director of Basic Research at the Byrd Institute and Professor of
Molecular Medicine. Dr. Woo, also a Byrd investigator, is an Assistant
Professor in the department of Molecular Pharmacology and Physiology. The new
project aims to understand how USP11, a multifunctional enzyme known to remove
ubiquitin chains from proteins, contributes to tau tangle pathology in the
development of Alzheimer’s disease (AD) and related tauopathies. Over the next
5 years, this grant will allow them to determine if USP11 activity and
associated mechanisms represent promising therapeutic targets to mitigate tau
pathogenesis in AD.
- Next steps will accelerate our Alzheimer’s Disease Research Center
The three main missions of the Byrd Alzheimer’s Center Division of Basic Research are 1.Identifying the root causes of dementia, 2. Devising promising strategies for therapeutic intervention, and 3. Early detection of dementia. This article discusses the research challenges and plans for the Byrd Institute to build a world-class Alzheimer’s disease (AD) research program.
- USF Research Day 2020 includes focus on Alzheimer’s
Keynote speaker, Allan Levey, MD, PhD, professor and chair at Emory University’s Department of Neurology, shared his perspective on “Racing to a Cure for Alzheimer’s Disease” at the USF Research Day 2020. His presentation on pursuing treatment and a cure for Alzheimer’s directly coincides with a focus of USF Health.
- Gopal Thinakaran pursues genetic clues to Alzheimer’s disease pathways
Gopal Thinakaran, PhD, professor of molecular medicine and
associate dean for neuroscience research at the USF Health Morsani College of
Medicine is conducting research that focuses on understanding genetic risk
factors that may offer new therapy targets to delay or protect against
age-related cognitive decline. Dr. Thinakaran oversees a laboratory at the Byrd
Alzheimer’s Institute where he uses cutting-edge cell biology techniques and
mouse models to study the molecular and cellular processes underlying
- The USF Neuroscience Institute announces the 2019 winners of the Dorothy Benjamin Graduate
Fellowship in Alzheimer’s Disease.
Dorothy Benjamin Fellowship is made possible by a generous donation from
Dorothy Benjamin with an Endowment for Alzheimer’s Research. Each year PhD students who are doing
research in Alzheimer’s disease are eligible to apply for a one to two year
fellowship that supports their research. This year two candidates were awarded $12,000 per year. The two candidates are Chao Ma and Yan Yan.
- Byrd NSI Investigator Dr. Blair launches a new
VA-funded research program
The Byrd Institute
announces the award of a $950,000 Veterans Affairs (VA) grant to Laura Blair, PhD, an Assistant Professor of Molecular Medicine and a Byrd NSI
Investigator. While the incidence of physical wounds has dropped in veterans,
many soldiers are returning from deployment suffering from psychological wounds
that manifest as post-traumatic stress disorder (PTSD) and major depressive
disorder (MDD). The major goal of this 4-year study is to develop strategies to
deplete the stress-associated protein FKBP51 while deepening the understanding
of FKBP51 biology, with the long-range goal of enhancing the psychological
resiliency of soldiers and veterans. Such efforts are also expected to help the
general population suffering from stress-related neurological disorders that
impair cognitive brain function.
Institute welcomes Dr. Gopal Thinakaran, PhD, an internationally
recognized Alzheimer’s disease researcher from the department of Neurobiology
at the University of Chicago. Supported by $5.5 million in National Institutes
of Health (NIH) grant funding, his research focuses on cutting-edge molecular and
cellular processes underlying Alzheimer’s disease and related dementias. At USF
Health, Dr. Thinakaran will assume leadership roles as associate dean for
neuroscience research, NSI associate director of research, and Bagnor Endowed
Chair in Alzheimer’s Research. He will also serve as Professor of Molecular
Medicine and Byrd Institute.
excited to welcome Dr. Angele Parent, PhD, from the University of
Chicago. She studies how the brain remembers and what goes wrong with memory
storage mechanisms in neurodegenerative diseases, focusing on communication
between nerve cells (synaptic transmission) and neuronal plasticity. She
recently received a 5-year $1.75 million NIH grant to examine how changes in
APP metabolism affect memory in sleep-disturbed Alzheimer’s models. Dr. Parent
will serve as Associate Professor of Molecular Medicine and Byrd Institute.
- Byrd Investigator Dr. Alexa Woo launches a new NIH-funded research program
We are excited to announce the award of a $1.8 million National Institutes of Health (NIH) grant to Dr. Jung A (Alexa) Woo, PhD, an Assistant Professor of Molecular Pharmacology & Physiology and a Byrd Investigator. Dr. Woo’s grant focuses on beta-arrestins, which are proteins classically known to bind and modify the function of cell surface receptors called GPCRs. Over the next 5 years, this grant will allow her to investigate how beta-arrestins alter the tau tangle protein to mitigate the pathogenesis of Alzheimer’s disease (AD), possibly leading to new AD therapies.
Interview with Dr. Laura Blair
The April 2019 issue of the eNeuro Journal, an official online scientific journal for the Society for Neuroscience, has featured an interview with Dr. Laura Blair, a Byrd investigator. In the interview, Dr. Blair talks about her recent publication in eNeuro describing the cellular and behavioral deficits in a transgenic mouse model in which the FKBP5 gene is overexpressed. Increased FKBP5 has been associated with several psychiatric disorders. The interview goes on to describe her research philosophy and the focus of her laboratory. Full detailed transcript of the interview and paper can be found here.
- The Byrd Institute is
pleased to welcome Dr. Lianchun Wang who has recently joined
the Byrd Institute as a Professor of Molecular Pharmacology & Physiology.
- Byrd Institute welcomes Dr. Krishna Bhat, who has recently joined the Byrd Institute as a Professor of Molecular Medicine and the Goldsmith Endowed Chair in Alzheimer’s Disease.
- Congratulations to Dr. Jeremy Baker and Dr. Dylan Finneran for successfully defending their dissertations on November 9th, 2018. Dr. Baker, who also received the Chih Foundation Research and Publication award, will begin his postdoctoral training at the University of Washington and VA Puget Sound in early 2019.Dr. Finneran will be joining our former colleague, Dave Morgan, at Michigan State University. The USF Health-NSI wish Drs. Baker and Finneran great success in their future endeavors.