2025

Blazier DM, Lewandowski EM, Ram N, Zhang X, Wang S, Patel O, Collier L, Defilippi P, Chen Y, and Thinakaran G: A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap. J Biol Chem. 2025, in press.

McMillan JD, Wang S, Wohlfahrt J, Guergues J, Stevens SM Jr., and Thinakaran G: Proteomic characterization of the Alzheimer’s disease risk factor BIN1 interactome. Molecular and Cellular Proteomics, 2025, in press. bioRxiv [Preprint] BIORXIV/2025/642169. 

Kozlova A, Zhang S, Sudwarts A, Zhang H, Smirnou S, Byeon SK, Thapa C, Sun X, Stephenson K, Zhao X, Jamison B, Ponnusamy M, He X, Schneider JA, Pandey A, Bennett DA, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G†, and Duan J†: PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia. Nature, in press, 2025. doi: 10.21203/rs.3.rs-4407146/v1. 

Zhao X, Li Y, Zhang S; Sudwarts A, Zhang H, Kozlova A, Moulton MJ, Goodman LD, Pang ZP, Sanders AR, Bellen HJ, Thinakaran G, and Duan J: Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication. Molecular Neurodegeneration, 2025, 20(1):51. doi: 10.1101/2024.08.14.24312009. 

Moreira-Silva D, Yuksel M, Ponnusamy M, Hansen MT, McMillan JD, Geethakrishnan S, Wang S, Collier LA, and Thinakaran G: Amylin exacerbates tau pathology in the visual cortex of diabetic mice by impairing lysosomal activity. Genes & Diseases, 2025. 12, 101602. doi:10.1016/j.gendis. 2025.101602. 

Arribas Gomez I, Yan Y, Lilley MT, Chen Y, Daughrity LM, Moreno Arnas A, Shi J, Kachergus JM, Thompson EA, Jansen-West K, Cook CN. Profiling the impact of different tau species on glial cell biology. Front Cell Dev Biol 2025. 17:13:1622138.  

Moss SE, McCurdy ES, Thomas NN, Gulick D, Poff AM, D'Agostino DP. Olfaction-based learned preference assessment without the use of motivational fear or motivational weight loss. Front Behav Neurosci. 2025 12;19:1521751 

Limam S, Patel A, Satav D, Miryala S, and Dharap A. Widespread induction of SINE-RNA expression in the mouse brain following transient focal ischemia. Experimental Neurology 2025. 

Patel A and Dharap A. Changes in 3D chromatin organization drive topologically determined gene expression in the post-stroke mouse cortex. Stroke 2025.

Yang SG, Li CP, Wang XW, Huang T, Qian C, Li Q, Zhao LR, Zhou SY, Ding CY, Nie R, Saijilafu, Hong YC, Liu CM, Zhou FQ. Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration. Adv Sci (Weinh). 2025 12(16):e2405537. doi: 10.1002/advs.202405537. Epub 2025 Feb 14. PMCID: PMC12021076. 

Auger A, Faidi R, Rickman AD, Martinez CP, Fajfer A, Carling J, Hilyard A, Ali M, Ono R, Cleveland C, Seliniotakis R, Truong N, Chefson A, Raymond M, Germain MA, Crackower MA, Heckmann BL. Post-symptomatic NLRP3 inhibition rescues cognitive impairment and mitigates amyloid and tau driven neurodegeneration. NPJ Dement. 2025;1(1):3. doi: 10.1038/s44400-025-00011-5. Epub 2025 May 6. PMCID: PMC12055592. 

 

2024

Paudel B, Jeong SY, Martinez CP, Rickman A, Haluck-Kangas A, Bartom ET, Fredriksen K, Affaneh A, Kessler JA, Mazzulli JR, Murmann AE, Rogalski E, Geula C, Ferreira A, Heckmann BL, Green DR, Sadleir KR, Vassar R, Peter ME. Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer's disease and aging. Nat Commun. 2024 15(1):264. doi: 10.1038/s41467-023-44465-8. PMCID: PMC10796375. 

Gebru NT, Beaulieu-Abdelahad D, Gulick D, Blair LJ. FKBP51 overexpression in the corticolimbic system stabilizes circadian rhythms. Cell Stress Chaperones. 2024 30(1):22-32. 

Khatskevich K, Patel J, Klein S, Shiver L, Mason A, Gulick D. How Student and Faculty Perceptions Differ on the Stressors that Medical Students Face. South Med J. 2024;117(6):336-341. 

Gebru NT, Guergues J, Verdina LA, Wohlfahrt J, Wang S, Armendariz DS, Gray M, Beaulieu-Abdelahad D, Stevens SM Jr, Gulick D, Blair LJ. Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics in aged mice. Aging Cell. 2024 Online 

Hernandez-Jimenez R, Patel A, Machado-Olavarria A, Mathieu H, Guergues J, Wohlfahrt J, Stevens Jr. S, and Dharap A. Cellular Resiliency and Survival of a Neuro-2a Cell Line Under Extreme Stress. Experimental Cell Research 2024. doi: 10.1016/j.yexcr.2024.114275. 

Patel A and Dharap A. An emerging role for enhancer RNAs in brain disorders. NeuroMolecular Medicine 2024. doi: 10.1007/s12017-024-08776-3. 

Mahoney HL, Bloom CA, Justin HS, Capraro BM, Morris C, Gonzalez D, Sandefur E, Faulkner J, Reiss S, Valladares A, Ocampo A, Carter B, Lussier AL, Dinh LP, Weeber E, Gamsby J, Gulick D. DISC1 and reelin interact to alter cognition, inhibition, and neurogenesis in a novel mouse model of schizophrenia. Front Cell Neurosci. 2024 17:1321632. doi: 10.3389/fncel.2023.1321632. eCollection 2023.  

Gebru NT, Beaulieu-Abdelahad D, Gulick D*, Blair LJ*. FKBP51 Overexpression in the Corticolimbic System Stabilizes Circadian Rhythms. Cell Stress Chaperones. 2024 30(1):22-32. doi: 10.1016/j.cstres.2024.12.003. PMCID: PMC11750455.  

Gebru NT, Guergues J, Verdina LA, Wohlfahrt J, Wang S, Armendariz DS, Gray M, Beaulieu-Abdelahad D, Stevens Jr SM, Gulick D, Blair LJ*. Fkbp5 Gene Deletion: Circadian Rhythm Profile and Brain Proteomics in Aged Mice Aging Cell. 2024 23(12):e14314. doi: 10.1111/acel.14314. Epub 2024 Sep 3. PubMed Central PMCID: PMC11634734. 

Xu M, Thottappillil N, Cherief M, Li Z, Zhu M, Xing X, Gomez-Salazar M, Mwirigi JM, Sankaranarayanan I, Tavares-Ferreira D, Zhang C, Wang XW, Archer M, Guan Y, Tower RJ, Cahan P, Price TJ, Clemens TL, James AW. Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing. bioRxiv [Preprint]. 2024 7:2024.06.06.597786. doi: 10.1101/2024.06.06.597786. PMCID: PMC11185682. 

 

2023

Aow J, Huang, T-R, Goh, Y-T, Xu A, Sun Y, Thinakaran G, and Koo EH. Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment. Cell Rep. 2023. 42(7):112774. doi: 10.1016/j.celrep.2023.112774. 

Ulku I, Liebsch F, Akerman SC, Schulz JF, Kulic L, Hock C, Pietrzik C, Di Spiezio A, Thinakaran G, Saftig P, Multhaup G. Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis. Scientific Reports, 2023. 13(1):2216. doi: 10.1038/s41598-023-28846-z. 

Ponnusamy M, Wang S, Yuksel M, Hansen MT, Blazier DM, McMillan JD, Zhang X, Dammer EB, Collier L, and Thinakaran G. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain, 2023. 146(4):1561-1579. doi: 10.1093/brain/awac318. 

Osborne OM, Naranjo O, Heckmann BL, Dykxhoorn D, Toborek M. Anti-amyloid: An antibody to cure Alzheimer's or an attitude. iScience. 2023 26(8):107461. doi: 10.1016/j.isci.2023.107461. PMCID: PMC10425904. 

Mahoney H, Bloom C, Justin H, Capraro B, Morris C, Gonzalez D, Sandefur E, Faulkner J, Reiss S, Vallardes A, Ocampo A, Carter B, Lussier, A, Dinh L, Weeber E, Gamsby J, Gulick D. DISC1 and Reelin interact to alter cognition, inhibition, and neurogenesis in a novel mouse model of schizophrenia. Front Cell Neuroscience 2023 Jan 12 (17). Online. 

Mason A, George Z, Gao X, Khatskevich K,  Zwygart K, Gulick D (2023). Matching against Men: Five Years of Residency Match Data Show Disparities Still Exist. South Med J 117(4):187-192. 

Esquivel AR, Hill SE, Blair LJ*. DnaJs are enriched in tau regulators. Int. J. Biol. Macromol. 2023 253(Pt 7):127486. doi: 10.1016/j.ijbiomac.2023.127486. Epub 2023 Oct 16. PubMed Central PMCID: PMC10842427.  

Hill SE, Beaulieu-Abdelahad D, Lemus A, Webster JM, Rodriguez Ospina S, Darling AL, Martin MD, Patel S, Bridenstine L, Swonger R, Paul S, Blackburn R, Calcul L, Dickey CA, Leahy JW, and Blair LJ*. Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation ACS Chem. Biol. 2023 18(5):1124-1135. doi: 10.1021/acschembio.2c00919. Epub 2023 May 5. PubMed Central PMCID: PMC10443619.

Gebru NT, Hill SE, Blair LJ*. Genetically Engineered Mouse Models of FK506-Binding Protein 5. J Cell Biochem. 2024 125(12):e30374. doi: 10.1002/jcb.30374. Epub 2023 Feb 13. Review. PubMed Central PMCID: PMC10423308. 

Jiang L, Chakraborty P, Zhang L, Wong M, Hill SE, Webber CJ, Libera J, Blair LJ, Wolozin B, Zweckstetter MA. Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Sci Adv. 2023 9(5):eadd9789. doi: 10.1126/sciadv.add9789. Epub 2023 Feb 1. PubMed Central PMCID: PMC9891691. 

Patel RS, Lui A, Hudson C, Moss L, Sparks RP, Hill SE, Shi Y, Cai J, Blair LJ, Bickford PC, Patel NA. Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model. Scientific Reports. 2023 13(1):317. doi: 10.1038/s41598-022-27126-6. PubMed Central PMCID: PMC9822944. 

Wang XW, Yang SG, Hu MW, Wang RY, Zhang C, Kosanam AR, Ochuba AJ, Jiang JJ, Luo X, Guan Y, Qian J, Liu CM, Zhou FQ. Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways. J Clin Invest. 2023 134(3):e163145. doi: 10.1172/JCI163145. PMCID: PMC10849760. 

 

2022

Sudwarts S, Ramesha S, Gao T, Ponnusamy P, Wang S, Hansen M, Kozlova A, Bitarafan S, Kumar P, Beaulieu-Abdelahad D, Zhang X, Collier L, Szekeres C, Wood LB, Duan J, Thinakaran G, and Rangaraju S. BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia. Mol Neurodeg. 2022. 17(1):33. doi: 10.1186/s13024-022-00535-x. 

Aow J, Huang T-R, Thinakaran G, and Koo EH. Enhanced cleavage of APP by co-expressed Bace1 alters 1 the distribution of APP and its fragments in neuronal and non-neuronal cells. Mol Neurobiol. 2022, doi: 10.1007/s12035-022-02733-6.  

Joshi, AD, Thinakaran G, and Elferink CJ. Cinnabarinic acid-induced stanniocalcin 2 confers cytoprotection against alcohol-induced liver injury. J Pharm and ExpTherap. 2022, JPET-AR-2021-000999. doi: 10.1124/jpet.121.000999 

Rickman AD, Hilyard A, Heckmann BL. Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration. Neural Regen Res. 2022 17(2):246-250. doi: 10.4103/1673-5374.317958. PMCID: PMC8463974. 

Peña-Martinez C, Rickman AD, Heckmann BL. Beyond autophagy: LC3-associated phagocytosis and endocytosis. Sci Adv. 2022 8(43):eabn1702. doi: 10.1126/sciadv.abn1702. Epub 2022 Oct 26. PMCID: PMC9604515.

Sephien A, Kumar A, Zwygart K, Mellek AR, Orr J, Nofsinger C, Gulick D. Association of an Early Interest in Orthopedic Surgery with Match Rate into Orthopedic Surgery. South Med J 2022. 115(11):813-817. 

Mason A, George Z, Gulick D. Student-Produced Guides alongside First-Year Medical Curriculum: How Peer-Produced Textbooks Change Student Success within Neurology, Cardiopulmonary, and Mixed Systems Courses. South Med J 2023. 116(2):162-169.  

Markoutsa E, Mayilsamy K, Gulick D, Mohapatra SS, Mohapatra S. Extracellular vesicles derived from inflammatory-educated stem cells reverse brain inflammation-implication of miRNAs. Mol Ther 2022. 30(2):816-830. 

Gonzalez D, Justin H,  Faulkner J, Mahoney H, Yunus A, Gamsby J, Gulick D. Circadian rhythm shifts and alcohol access in adolescence synergistically increase alcohol preference and intake in adulthood in male C57BL/6 mice. Behavioural Brain Research 2022. 2023;438:114216.  

Nenninger AW, Willman M, Willman J, Stewart E, Mesidor P, Novoa M, Morrill NK, Alvarez L, Joly-Amado A, Peters MM, Gulick D, Nash KR. (2022) Improving Gene Therapy for Angelman Syndrome with Secreted Human UBE3A. Neurotherapeutics. 2022 

Gonzalez D, Justin H, Samantha Reiss, Faulkner J, Mahoney H, Yunis A, Gamsby J, Gulick D. Circadian rhythm shifts and alcohol access in adolescence synergistically increase alcohol preference and intake in adulthood in male C57BL/6 mice. Behavioral Brain Research. Feb 13;438:114216. doi: 10.1016/j.bbr.2022.114216. Epub 2022. 

Green R, Mayilsamy K, McGill AR, Martinez T, Chandran B, Blair LJ, Bickford PC, Mohapatra SS, Mohapatra S. SARS-CoV-2 Infection Increases the Gene Expression Profile for Alzheimer's Disease Risk. Mol Ther Methods Clin Dev. 2022 27:217-229. doi: 10.1016/j.omtm.2022.09.007. Epub 2022 Sep 24. PubMed Central PMCID: PMC9508696.  

Zhu Y, Gandy L, Zhang F, Liu J, Wang C, Blair LJ, Linhardt RJ, Wang L. Heparan Sulfate Proteoglycans in Tauopathy. Biomolecules. 2022 12(12). doi: 10.3390/biom12121792. Review. PubMed Central PMCID: PMC9776397. 

Hill SE, Esquivel AR, Rodriguez Ospina S, Rahal LM, Dickey CA, Blair LJ*. Chaperoning activity of the cyclophilin family prevents tau aggregation. Protein Science. 2022 31(11):e4448. doi: 10.1002/pro.4448. PubMed Central PMCID: PMC9597375.  

Criado-Marrero M, Blazier DM, Gould LA, Gebru NT, Rodriguez Ospina S, Armendariz DS, Darling AL, Beaulieu-Abdelahad D, Blair LJ*. Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice Scientific Reports. 2022 12(1):7372. doi: 10.1038/s41598-022-11025-x. PubMed Central PMCID: PMC9072347.  

Rodriguez Ospina S, Blazier DM, Criado-Marrero M, Gould LA, Gebru NT, Beaulieu-Abdelahad D, Wang X, Remily-Wood E, Chaput D, Stevens S, Uversky VN, Bickford PC, Dickey CA, Blair LJ*. Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain. Int. J. Mol. Sci. 2022, 23, (2). doi: 10.3390/ijms23020851PubMed Central PMCID: PMC8775832.