PhD, Pharmacology, the Hebrew University of Jerusalem, 2005
Interdisciplinary and Emerging Signature Programs
Allergy, Immunology & Infectious Disease
Biomedical Engineering & Nanomedicine
Cardiovascular Sciences
Women & Children's Health
Research Interests
Research at the Totary-Jain lab focuses on elucidating the role of non-coding RNA in cardiovascular disease and in antiviral innate immunity. The main projects aim to: 1) Develop site- and cell-selective anti-atherosclerotic nanotherapies that simultaneously inhibit infiltration and proliferation of inflammatory and vascular smooth muscle cells while preserving the integrity of endothelial cells. 2) investigate the role of LIN28B/let-7 switch in the pathogenesis of infantile hemangioma. 3) elucidate the role of retrotransposons in the placental intrinsic protection against viral vertical transmission.
Awards/Honors
Alan T. Hirsch Mid-Career Award in Vascular Medicine, AHA (American Heart Association (AHA) - 2020)
PVD/Robert W. Hobson, II, MD Early Career Investigator Award (American Heart Association (AHA) - 2013)
NIH Pathway to Independence Award (NIH/NHLBI - 2011)
NIH Postdoctoral Fellowship Award (NIH/NHLBI - 2008)
The Diabetes Research Centre of the Hebrew University (The Hebrew University of Jerusalem - 2004)
Israel Ministry of Science Fellowship Award (Israel Ministry of Science - 2003)
Recent Publications
Ishani Wickramage, Jeffrey VanWye, Klaas Max, John H Lockhart, Ismet Hortu, Ezinne F Mong, John Canfield, Hiran M Lamabadu Warnakulasuriya Patabendige, Ozlem Guzeloglu-Kayisli, Kimiko Inoue, Atsuo Ogura, Charles J Lockwood, Kemal M Akat, Thomas Tuschl, Umit A Kayisli, Hana Totary-Jain SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentasCell Host and Microbe. doi: 10.1016/j.chom.2023.05.018, 2023.
Isabella Hetherington, Hana Totary-Jain Anti-atherosclerotic therapies: Milestones, challenges, and emerging innovationsMolecular Therapy. DOI: 10.1016/j.ymthe.2022.08.024, 2022.
Lockhart JH, VanWye J, Banerjee R, Wickline SA, Pan H, Totary-Jain Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis.Molecular Therapy. DOI: 10.1016/j.ymthe.2021.01.032, 2021.
Mong E, Yang Y, Akat K, Canfield J, VanWye J, Lockhart J, Tsibris J, Schatz F, Lockwood C, Tuschl T, Kayisli U, Totary-Jain Chromosome 19 microRNA cluster enhances cell reprogramming by inhibiting epithelial-to-mesenchymal transitionScientific Reports. DOI: 10.1038/s41598-020-59812-8, 2020.
Canfield J, Arlier S, Mong EF, Lockhart J, VanWye J, Guzelogu-Kayisli O, Schatz F, Magness RR, Lockwood CJ, Tsibris J, Kayisli U, Totary-Jain H Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migrationFASEB J. DOI: 10.1096/fj.201801163R, 2019.
Mong EF, Akat KM, Canfield J, Lockhart J, VanWye J, Matar A, Tsibris JCM, Wu JK, Tuschl T, Totary-Jain H Modulation of LIN28B/Let-7 signaling by propranolol contributes to infantile hemangioma involutionAtherosclerosis Thrombosis and Vascular Biology. DOI: 10.1161/ATVBAHA.118.310908, 2018.
Canfield J & Totary-Jain H 40 Years of Percutaneous Coronary Intervention: History and Future DirectionsJournal of Personalized Medicine. DOI: 10.3390/jpm8040033, 2018.
Totary-Jain H, Sionov RV, Gallily R. Indomethacin sensitizes resistant transformed cells to macrophage cytotoxicity.Immunology Letters. DOI: 10.1016/j.imlet.2016.05.011, 2016.
Santulli G, Wronska A, Uryu K, Diacovo TG, Gao M, Marx SO, Kitajewski J, Chilton JM, Akat KM, Tuschl T, Marks AR, Totary-Jain H. A selective microRNA-based strategy inhibits restenosis while preserving endothelial function.The Journal of clinical investigation. DOI: 10.1172/JCI76069, 2014.
Akat KM, Moore-McGriff D, Morozov P, Brown M, Gogakos T, Correa Da Rosa J, Mihailovic A, Sauer M, Ji R, Ramarathnam A, Totary-Jain H, Williams Z, Tuschl T, Schulze PC. Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers.Proceedings of the National Academy of Sciences of the United States of America. 111(30) : 11151-6, 2014.
Totary-Jain H, Sanoudou D, Ben-Dov IZ, Dautriche CN, Guarnieri P, Marx SO, Tuschl T, Marks AR. Reprogramming of the microRNA transcriptome mediates resistance to rapamycin.The Journal of biological chemistry. 288(9) : 6034-44, 2013.
Santulli G, Totary-Jain H. Tailoring mTOR-based therapy: molecular evidence and clinical challenges.Pharmacogenomics. 14(12) : 1517-26, 2013.
Totary-Jain H, Sanoudou D, Dautriche CN, Schneller H, Zambrana L, Marks AR. Rapamycin resistance is linked to defective regulation of Skp2.Cancer research. 72(7) : 1836-43, 2012.
Marx SO, Totary-Jain H, Marks AR. Vascular smooth muscle cell proliferation in restenosis.Circulation. Cardiovascular interventions. 4(1) : 104-11, 2011.
Shan J, Nguyen TB, Totary-Jain H, Dansky H, Marx SO, Marks AR. Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors.Proceedings of the National Academy of Sciences of the United States of America. 105(48) : 19006-11, 2008.
Totary-Jain H, Naveh-Many T, Riahi Y, Kaiser N, Eckel J, Sasson S. Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high-glucose conditions.Circulation research. 97(10) : 1001-8, 2005.
Alpert E, Altman H, Totary H, Gruzman A, Barnea D, Barash V, Sasson S. 4-Hydroxy tempol-induced impairment of mitochondrial function and augmentation of glucose transport in vascular endothelial and smooth muscle cells.Biochemical pharmacology. 67(10) : 1985-95, 2004.
Alpert E, Gruzman A, Totary H, Kaiser N, Reich R, Sasson S. A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid.The Biochemical journal. 362(Pt 2) : 413-22, 2002.
Cerasi E, Marshak S, Totary H, Melloul D. [1997 Maurice Dérot. Transcriptional regulation of the insulin gene: a step toward gene therapy of diabetes].Journées annuelles de diabétologie de l''Hôtel-Dieu. : 299-304, 1997.
Marshak S, Totary H, Cerasi E, Melloul D. Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells.Proceedings of the National Academy of Sciences of the United States of America. 93(26) : 15057-62, 1996.
