Srinivas Tipparaju, PhD

Professor and Chair, Pharmaceutical Sciences

Contact Info 12901 Bruce B. Downs Blvd.
MDC 030
Tampa 33612

Academic Email: stippara@usf.edu

Academic Phone:(813) 974-7195

Education

Interdisciplinary and Emerging Signature Programs

• Cardiovascular Sciences

Memberships

• Member (APS, 2013 - Present)
• Member (AACP, 2011 - 2015)
• Member (AHA, 2003 - Present)

Recent Publications

• Manickam R, Virzi J, Potti A, Cheng F, Russ DW, Tipparaju SM. Genetic deletion of Kvβ2 (AKR6) causes loss of muscle function and increased inflammation in mice. Frontier Aging. 4: 1175510, 2023.
• Tur J, Badole SL, Manickam R, Chapalamadugu KC, Xuan W, Guida W, Crews JJ, Bisht KS, Tippa Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation. J Pharmacol Exp Ther.. 382(2) : 233-245, 2022.
• Sutariya V, Kelly SJ, Weigel RG, Tur J, Halasz K, Sharma NS, Tipparaju SM. Nanoparticle drug delivery characterization for fluticasone propionate and in vitro testing . Canadian journal of physiology and pharmacology. 97(7) : 675-684, 2019.
• Chapalamadugu KC, Tur J, Badole SL, Kukreja RC, Brotto M, Tipparaju SM. Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation. Acta physiologica (Oxford, England). 224(2) : e13083, 2018.
• Carris NW, Tsalatsanis A, Tipparaju SM, Cheng F, Magness RR, Kumar A. Metformin''s impact on statin-associated muscle symptoms: An analysis of ACCORD study data and research materials from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center. Diabetes, obesity & metabolism. 20(8) : 1994-1999, 2018.
• Sutariya V, Tur J, Kelly S, Halasz K, Chapalamadugu KC, Nimbalkar R, Pathak YV, Weigel R, Daviau T, Webb T, Cacace J, Brotto M, Tipparaju SM. Nanodrug delivery platform for glucocorticoid use in skeletal muscle injury. Canadian journal of physiology and pharmacology. 96(7) : 681-689, 2018.
• Doggett TM, Tur JJ, Alves NG, Yuan SY, Tipparaju SM, Breslin JW. Assessment of Cardiovascular Function and Microvascular Permeability in a Conscious Rat Model of Alcohol Intoxication Combined with Hemorrhagic Shock and Resuscitation. Methods in molecular biology (Clifton, N.J.). 1717: 61-81, 2018.
• Tur J, Badole SL, Cheng F, Das A, Kukreja RC, Tipparaju SM. Corticosteroids and aldose reductase inhibitor Epalrestat modulates cardiac action potential via Kvβ1.1 (AKR6A8) subunit of voltage-gated potassium channel. Molecular and cellular biochemistry. 436(1-2) : 71-78, 2017.
• Carris NW, Tipparaju SM, Magness DJ, Chapalamadugu KC, Magness RR. Pleiotropic effects of metformin to rescue statin-induced muscle injury and insulin resistance: A proposed mechanism and potential clinical implications. Medical hypotheses. 107: 39-44, 2017.
• Tur J, Chapalamadugu KC, Katnik C, Cuevas J, Bhatnagar A, Tipparaju SM. Kvβ1.1 (AKR6A8) senses pyridine nucleotide changes in the mouse heart and modulates cardiac electrical activity. American journal of physiology. Heart and circulatory physiology. 312(3) : H571-H583, 2017.
• MohanKumar K, Namachivayam K, Chapalamadugu KC, Garzon SA, Premkumar MH, Tipparaju SM, Maheshwari A. Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis. Pediatric research. 79(6) : 951-61, 2016.
• Tur J, Chapalamadugu KC, Padawer T, Badole SL, Kilfoil PJ, Bhatnagar A, Tipparaju SM. Deletion of Kvβ1.1 subunit leads to electrical and haemodynamic changes causing cardiac hypertrophy in female murine hearts. Experimental physiology. 101(4) : 494-508, 2016.
• Chapalamadugu KC, Panguluri SK, Bennett ES, Kolliputi N, Tipparaju SM. High level of oxygen treatment causes cardiotoxicity with arrhythmias and redox modulation. Toxicology and applied pharmacology. 282(1) : 100-7, 2015.
• Puri M, Chapalamadugu KC, Miranda AC, Gelot S, Moreno W, Adithya PC, Law C, Tipparaju SM. Integrated approach for smart implantable cardioverter defibrillator (ICD) device with real time ECG monitoring: use of flexible sensors for localized arrhythmia sensing and stimulation. Frontiers in physiology. 4: 300, 2013.
• Panguluri SK, Tur J, Fukumoto J, Deng W, Sneed KB, Kolliputi N, Bennett ES, Tipparaju SM. Hyperoxia-induced hypertrophy and ion channel remodeling in left ventricle. American journal of physiology. Heart and circulatory physiology. 304(12) : H1651-61, 2013.
• Panguluri SK, Tur J, Chapalamadugu KC, Katnik C, Cuevas J, Tipparaju SM. MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators. PloS one. 8(4) : e60545, 2013.
• Kilfoil PJ, Tipparaju SM, Barski OA, Bhatnagar A. Regulation of ion channels by pyridine nucleotides. Circulation research. 112(4) : 721-41, 2013.
• Tipparaju SM, Li XP, Kilfoil PJ, Xue B, Uversky VN, Bhatnagar A, Barski OA. Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating. Pflugers Archiv : European journal of physiology. 463(6) : 799-818, 2012.
• Kolliputi N, Galam L, Parthasarathy PT, Tipparaju SM, Lockey R. NALP-3 inflammasome silencing attenuates ceramide induced transepithelial permeability. Journal of cellular physiology. , 2011.
• Xie Z, Barski OA, Cai J, Bhatnagar A, Tipparaju SM. Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6). Chemico-biological interactions. 191(1-3) : 255-60, 2011.
• Barski OA, Tipparaju SM, Bhatnagar A. Kinetics of nucleotide binding to the beta-subunit (AKR6A2) of the voltage-gated potassium (Kv) channel. Chemico-biological interactions. 178(1-3) : 165-70, 2009.
• Tipparaju SM, Barski OA, Srivastava S, Bhatnagar A. Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel. Biochemistry. 47(34) : 8840-54, 2008.
• Barski OA, Tipparaju SM, Bhatnagar A. The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. Drug metabolism reviews. 40(4) : 553-624, 2008.
• Tipparaju SM, Liu SQ, Barski OA, Bhatnagar A. NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels. Biochemical and biophysical research communications. 359(2) : 269-76, 2007.

Awards/Honors

• FCVS (APS - 2019)
• Best Researcher Award (USF - 2014)
• Fellow (CTI and Faculty Leadership Academy USF COP - 2013)
• AHA BGIA (AHA - 2008)
• AHA postdoctoral fellowship (AHA - 2003)