PhD, Physiological Sciences, University of Arizona, 2006
MS, Physiological Sciences, University of Arizona, 2004
BS, Veterinary Science, University of Arizona, 2001
Interdisciplinary and Emerging Signature Programs
Allergy, Immunology & Infectious Disease
Cardiovascular
Cellular and Molecular Biology
Metabolic Regulation and Disorders
Other
Research Interests
Medical physiology education
As a translational physiologist, my main interest lies in how the body functions from the subcellular level up to the level of integration of biological systems in the whole organism. I am specifically interested in elucidating mechanisms underlying the body's response to critical illness. My research interest is based in intestinal pathophysiology and my projects have focused on evaluating the mechanisms behind growth factor- and probiotic-mediated intestinal protection in murine models sepsis. Most recently, my research has expanded to investigate intestinal function in the context of systemic diseases such as obesity and type 2 diabetes mellitus.
Awards/Honors
Epithelial Transport Group Excellence in Research Award (American Physiological Society - 2016)
Chrysalis Award for Transformative Service (Bastyr University California - 2015)
Dale J. Benos Early Career Professional Service Award (American Physiological Society - 2011)
Early Career Investigator Fellowship (Shock Society - 2009)
Ison-Franklin Fellow, Porter Physiology Fellowship (American Physiological Society - 2005)
Centennial Achievement Award (University of Arizona - 2005)
Merck Fellow, Porter Physiology Fellowship (American Physiological Society - 2004)
Memberships
Member (American Physiological Society, 2004 - Present)
Recent Publications
Fenton RA, Poulsen SB, de la Mora Chavez S, Soleimani M, Dominguez Rieg JA, Rieg T. Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis.Kidney international. , 2017.
Rieg T Dominguez Rieg JA. Reply to “Reduced NHE3 activity results in congenital
diarrhea and can predispose to inflammatory bowel disease.”Am J Physiol Regul Integr Comp Physiol,. 312(3) : R312, 2017.
Dominguez Rieg JA, Chirasani VR, Koepsell H, Senapati S, Mahata SK, Rieg T. Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice.Laboratory investigation; a journal of technical methods and pathology. 96(1) : 98-111, 2016.
Dominguez Rieg JA, de la Mora Chavez S, Rieg T. Novel developments in differentiating the role of renal and intestinal sodium hydrogen exchanger 3.American journal of physiology. Regulatory, integrative and comparative physiology. 311(6) : R1186-R1191, 2016.
Yoseph BP, Klingensmith NJ, Liang Z, Breed ER, Burd EM, Mittal R, Dominguez JA, Petrie B, Ford ML, Coopersmith CM. Mechanisms of Intestinal Barrier Dysfunction in Sepsis.Shock (Augusta, Ga.). 46(1) : 52-9, 2016.
Dominguez Rieg JA, Burt JM, Ruth P, Rieg T. P2Y₂ receptor activation decreases blood pressure via intermediate conductance potassium channels and connexin 37.Acta physiologica (Oxford, England). 213(3) : 628-41, 2015.
Fenton RA, Poulsen SB, de la Mora Chavez S, Soleimani M, Busslinger M, Dominguez Rieg JA, Rieg T. Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3.American journal of physiology. Renal physiology. 308(12) : F1409-20, 2015.
Liang Z, Xie Y, Dominguez JA, Breed ER, Yoseph BP, Burd EM, Farris AB, Davidson NO, Coopersmith CM. Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice.PloS one. 9(7) : e101828, 2014.
Fenton RA, Murray F, Dominguez Rieg JA, Tang T, Levi M, Rieg T. Renal phosphate wasting in the absence of adenylyl cyclase 6.Journal of the American Society of Nephrology : JASN. 25(12) : 2822-34, 2014.
Dominguez JA, Samocha AJ, Liang Z, Burd EM, Farris AB, Coopersmith CM. Inhibition of IKKβ in enterocytes exacerbates sepsis-induced intestinal injury and worsens mortality.Critical care medicine. 41(10) : e275-85, 2013.
Jung E, Perrone EE, Brahmamdan P, McDonough JS, Leathersich AM, Dominguez JA, Clark AT, Fox AC, Dunne WM, Hotchkiss RS, Coopersmith CM. Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury.PloS one. 8(10) : e77203, 2013.
Khailova L, Frank DN, Dominguez JA, Wischmeyer PE. Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis.Anesthesiology. 119(1) : 166-77, 2013.
Fox AC, McConnell KW, Yoseph BP, Breed E, Liang Z, Clark AT, O''Donnell D, Zee-Cheng B, Jung E, Dominguez JA, Dunne WM, Burd EM, Coopersmith CM. The endogenous bacteria alter gut epithelial apoptosis and decrease mortality following Pseudomonas aeruginosa pneumonia.Shock (Augusta, Ga.). 38(5) : 508-14, 2012.
Perrone EE, Jung E, Breed E, Dominguez JA, Liang Z, Clark AT, Dunne WM, Burd EM, Coopersmith CM. Mechanisms of methicillin-resistant Staphylococcus aureus pneumonia-induced intestinal epithelial apoptosis.Shock (Augusta, Ga.). 38(1) : 68-75, 2012.
Jung E, Perrone EE, Liang Z, Breed ER, Dominguez JA, Clark AT, Fox AC, Dunne WM, Burd EM, Farris AB, Hotchkiss RS, Coopersmith CM. Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines.Shock (Augusta, Ga.). 37(1) : 85-94, 2012.
Dominguez JA, Xie Y, Dunne WM, Yoseph BP, Burd EM, Coopersmith CM, Davidson NO. Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia.PloS one. 7(11) : e49159, 2012.
Dominguez JA. Use of minimal enteral nutrition to prevent necrotizing enterocolitis: got milk?JPEN. Journal of parenteral and enteral nutrition. 35(1) : 14-5, 2011.
McConnell KW, Fox AC, Clark AT, Chang NY, Dominguez JA, Farris AB, Buchman TG, Hunt CR, Coopersmith CM. The role of heat shock protein 70 in mediating age-dependent mortality in sepsis.Journal of immunology (Baltimore, Md. : 1950). 186(6) : 3718-25, 2011.
Fox AC, Breed ER, Liang Z, Clark AT, Zee-Cheng BR, Chang KC, Dominguez JA, Jung E, Dunne WM, Burd EM, Farris AB, Linehan DC, Coopersmith CM. Prevention of lymphocyte apoptosis in septic mice with cancer increases mortality.Journal of immunology (Baltimore, Md. : 1950). 187(4) : 1950-6, 2011.
Dominguez JA, Vithayathil PJ, Khailova L, Lawrance CP, Samocha AJ, Jung E, Leathersich AM, Dunne WM, Coopersmith CM. Epidermal growth factor improves survival and prevents intestinal injury in a murine model of pseudomonas aeruginosa pneumonia.Shock (Augusta, Ga.). 36(4) : 381-9, 2011.
Dominguez JA, Coopersmith CM. Can we protect the gut in critical illness? The role of growth factors and other novel approaches.Critical care clinics. 26(3) : 549-65, x, 2010.
Fox AC, Robertson CM, Belt B, Clark AT, Chang KC, Leathersich AM, Dominguez JA, Perrone EE, Dunne WM, Hotchkiss RS, Buchman TG, Linehan DC, Coopersmith CM. Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis.Critical care medicine. 38(3) : 886-93, 2010.
Rieg T, Dominguez JA. Unravelling a role for KCNQ1 in K+ recycling and gastric acid secretion.The Journal of physiology. 587(Pt 17) : 4149-50, 2009.
