Molecular Pharmacology and Physiology

Jerome Breslin I-3790-2012

Jerome Breslin, PhD

Director of Graduate Programs, College of Medicine Molecular Pharmacology & Physiology

Professor, Non USF Health

Professor, College of Medicine Molecular Pharmacology & Physiology

Contact Info 12901 Bruce B Downs Blvd MDC8
Tampa FL 33612

Academic Email:

Academic Phone:(813) 974-7631

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  • PhD, Pharmacology & Physiology, University of Medicine and Dentistry of New Jersey, 2002
  • MS, Biology, Seton Hall Universtiy, 1998
  • BA, Biological Sciences, Rutgers University, 1993

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cardiovascular
  • Cardiovascular Sciences
  • Cellular and Molecular Biology

Research Interests

  • My research area of interest is inflammation, with emphasis on the mechanisms that underlie swelling of tissues, or edema. Our laboratory focuses on two phenomena: First, we aim to understand the molecular signaling pathways and effector molecules in endothelial cells that initiate, sustain, and regulate the increased microvascular permeability that accompanies inflammation. This is important for understanding how excess fluid can accumulate in tissues. Second, we are studying the molecular mechanisms that control the intrinsic pumping of lymphatic vessels, which contributes to removing excess fluids from tissues. Understanding how these processes work is important for developing better strategies for resuscitation of trauma patients, wound healing, and optimizing immune function.


  • American Heart Association (Member, 2007 - Present)
  • American Association for the Advancement of Science (Member, 2005 - Present)
  • American Society for Cell Biology (Member, 2003 - Present)
  • American Physiological Society (Member, 2001 - Present)
  • The Microcirculatory Society (Member, 2000 - Present)

Recent Publications

  • Motherwell JM, Azimi MS, Spicer K, Alves NG, Hodges NA, Breslin JW, Katakam PVG, Murfee WL. Evaluation of Arteriolar Smooth Muscle Cell Function in an Ex Vivo Microvascular Network Model. Scientific reports. 7(1) : 2195, 2017.
  • Doggett TM, Alves NG, Yuan SY, Breslin JW. Sphingosine-1-Phosphate Treatment Can Ameliorate Microvascular Leakage Caused by Combined Alcohol Intoxication and Hemorrhagic Shock. Scientific reports. 7(1) : 4078, 2017.
  • Trujillo AN, Katnik C, Cuevas J, Cha BJ, Taylor-Clark TE, Breslin JW. Modulation of mesenteric collecting lymphatic contractions by σ1-receptor activation and nitric oxide production. American journal of physiology. Heart and circulatory physiology. 313(4) : H839-H853, 2017.
  • Breslin JW. Cellular cross talk, inflammatory signals, and enhanced microvascular permeability. Microcirculation (New York, N.Y. : 1994). 24(3) , 2017.
  • Breslin JW, Daines DA, Doggett TM, Kurtz KH, Souza-Smith FM, Zhang XE, Wu MH, Yuan SY. Rnd3 as a Novel Target to Ameliorate Microvascular Leakage. Journal of the American Heart Association. 5(4) : e003336, 2016.
  • Zhang XE, Adderley SP, Breslin JW. Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. PloS one. 11(5) : e0155490, 2016.
  • Sloas DC, Stewart SA, Sweat RS, Doggett TM, Alves NG, Breslin JW, Gaver DP, Murfee WL. Estimation of the Pressure Drop Required for Lymph Flow through Initial Lymphatic Networks. Lymphatic research and biology. 14(2) : 62-9, 2016.
  • Breslin JW., Zhang XE., Worthylake RA., & Souza-Smith FM. Involvement of local lamellipodia in endothelial barrier function. PLOS One. 10: e0117970, 2015.
  • Trujillo A & Breslin JW. Lymphaticosclerosis: a new way of thinking about lymphatic vessel obstruction. The British Journal of Dermatology. 172(5) : 1184-5, 2015.
  • Souza-Smith FM, Kerut EK, Breslin JW, & Molina PE. Mechanisms of Acute Alcohol Intoxication-Induced Modulation of Cyclic Mobilization of [Ca²⁺] in Rat Mesenteric Lymphatic Vessels. Lymphatic Research and Biology. 13(2) : 93-9, 2015.
  • Hooper JS, Hadley S, Morris KF, Breslin JW, Dean JB, & Taylor-Clark TE. Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin and ATP in Sprague Dawley rats. Journal of Applied Physiology (Bethesda, Md.: 1985). : jap.00944.2015, 2015.
  • Adderley SP., Lawrence C., Madonia E., Olubadewo JO., & Breslin JW. Histamine activates p38 MAP kinase and alters local lamellipodia dynamics, reducing endothelial barrier integrity and eliciting central movement of actin fibers. American Journal of Physiology. Cell Physiology. 309: C51-C59, 2015.
  • Adderley SP., Zhang XE., & Breslin JW. Involvement of the H1 histamine receptor, p38 MAP kinase, MLCK, and Rho/ROCK in histamine-indcued endothelial barrier dysfunction. Microcirculation. 22(4) : 237-248, 2015.
  • Breslin JW. Mechanical forces and lymphatic transport. Microvascular Research. 96: 46-54, 2014.
  • Kurtz KH, Souza-Smith FM, Moor AN, & Breslin JW. Rho kinase enhances contractions of rat mesenteric collecting lymphatics. PloS One. 9(4) : e94082, 2014.
  • Kurtz KH, Moor AN, Souza-Smith FM, Breslin JW. Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics. Microcirculation. 21(7) : 593-605, 2014.
  • Doggett TM & Breslin JW. Acute alcohol intoxication-induced microvascular leakage. Alcoholism, Clinical and Experimental Research. 38(9) : 2414-26, 2014.
  • Souza-Smith FM, Molina PE, & Breslin JW. Reduced RhoA Activity Mediates Acute Alcohol Intoxication-Induced Inhibition of Lymphatic Myogenic Constriction Despite Increased Cytosolic [Ca(2+) ]. Microcirculation (New York, N.Y. : 1994). 20(5) : 377-84, 2013.
  • Doggett TM & Breslin JW. Study of the actin cytoskeleton in live endothelial cells expressing GFP-actin. Journal of Visualized Experiments: JoVE. (57) , 2011.
  • Souza-Smith FM, Kurtz KM, & Breslin JW. Measurement of cytosolic Ca2+ in isolated contractile lymphatics. Journal of Visualized Experiments: JoVE. (58) , 2011.
  • Breslin JW. ROCK and cAMP promote lymphatic endothelial cell barrier integrity and modulate histamine and thrombin-induced barrier dysfunction. Lymphatic Research and Biology. 9(1) : 3-11, 2011.
  • Durán WN, Breslin JW, & Sánchez FA. The NO cascade, eNOS location, and microvascular permeability. Cardiovascular Research. 87(2) : 254-61, 2010.
  • Souza-Smith FM, Kurtz KM, Molina PE, Breslin JW. Adaptation of mesenteric collecting lymphatic pump function following acute alcohol intoxication. Microcirculation (New York, N.Y. : 1994). 17(7) : 514-24, 2010.
  • Breslin JW & Kurtz KM. Lymphatic endothelial cells adapt their barrier function in response to changes in shear stress. Lymphatic Research and Biology. 7(4) : 229-37, 2009.


  • Fellow (American Physiological Society Cardiovascular Section - 2015)
  • Travel Award for Outstanding Young Investigators (The Microcirculatory Society, Inc. - 2012)