Molecular Pharmacology and Physiology

Jay Dean

Jay Dean, Ph.D.

Professor (With Tenure), Dept. of Molecular Pharmacology & Physiology, College of Medicine

Adjunct Professor, Department of Military and Emergency Medicine

Professor, College of Medicine Molecular Pharmacology & Physiology

Contact Info 12901 Bruce B. Downs Blvd.
MDC 7
Tampa FL 33612

Academic Email: jdean@health.usf.edu

Academic Phone:(813) 974-1547

View My C.V.

Education

  • PHD, Physiology, the Ohio State University, 1986
  • MS, Respiration Physiology, Michigan Technological University, 1981
  • B.S., Biology, Central Michigan University, 1979

Academic Philosophy

"To train and educate future physiologists and biomedical professionals in the theory, principles and practices of physiology while fostering an academic environment that encourages scientific discovery and appreciation for our scientific heritage."

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cancer Biology
  • Cardiovascular
  • Cellular and Molecular Biology
  • Environmental & Global Health
  • Neuroscience
  • Neuroscience
  • Other
  • Oxygen Toxicity
  • Pulmonary Physiology

Research Interests

  • We study the effects of O2, CO2 and barometric pressure on the function of the mammalian CNS, with an emphasis on the cardio-respiratory and gastro-esophageal control systems. Ongoing research focuses on understanding how hyperoxia and hypercapnia interact to generate reactive O2 and N2 species that, in turn, activate neuronal activity in the brain stem. This research has relevance to understanding normal and abnormal function in cardio-respiratory control during periods of disordered breathing, environmental stresses, and in understanding neurological problems arising from the use of hyperoxia in clinical medicine and combat operations. We are particularly interested in the following: 1) neurophysiology of CNS oxygen toxicity (seizures); 2) understanding how CO2 and H-ions are “sensed” by chemoreceptor neurons in the caudal brain stem; and 3) understanding how gastro-esophageal CO2 ventilation supplements pulmonary ventilation during chronic respiratory acidosis.

Memberships

  • Journal of Applied Physiology (Associate Editor, 2008 - Present)
  • American Journal of Biomedical Sciences (Member of Editorial Board, 2008 - Present)
  • Undersea and Hyperbaric Medicine (Member of Editorial Board, 2002 - Present)
  • Journal of Applied Physiology (Member of Editorial Board, 1999 - 2008)

Recent Publications

  • Hooper JS, Hadley S, Morris KF, Breslin JW, Dean JB, & Taylor-Clark TE. Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin and ATP in Sprague Dawley rats. Journal of Applied Physiology (Bethesda, Md.: 1985). : jap.00944.2015, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26718787
  • Nuding SC, Segers LS, Iceman KE, O'Connor R, Dean JB, Bolser DC, Baekey DM, Dick TE, Shannon R, Morris KF, & Lindsey BG. Functional connectivity in raphé-pontomedullary circuits supports active suppression of breathing during hypocapnic apnea. Journal of Neurophysiology. 114(4) : 2162-86, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26203111
  • Matott MP, Ciarlone GE, Putnam RW, & Dean JB. Normobaric hyperoxia (95% O₂) stimulates CO₂-sensitive and CO₂-insensitive neurons in the caudal solitary complex of rat medullary tissue slices maintained in 40% O₂. Neuroscience. 270: 98-122, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24704511
  • D'Agostino DP, Putnam RW, Dean JB. Superoxide ({middle dot}O2 ) Production in CA1 Neurons of Rat Hippocampal Slices Exposed to Graded Levels of Oxygen. Journal of neurophysiology. 98(2) : 1030-41, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17553943
  • Dean JB. Metabolic acidosis inhibits hypothalamic warm-sensitive receptors: a potential causative factor in heat stroke. Journal of applied physiology (Bethesda, Md. : 1985). 102(4) : 1312, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17204570
  • Ritucci NA, Dean JB, Putnam RW. Somatic vs. dendritic responses to hypercapnia in chemosensitive locus coeruleus neurons from neonatal rats. American journal of physiology. Cell physiology. 289(5) : C1094-104, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16014703
  • Dean JB, Mulkey DK, Henderson RA, Potter SJ, Putnam RW. Hyperoxia, reactive oxygen species, and hyperventilation: oxygen sensitivity of brain stem neurons. Journal of applied physiology (Bethesda, Md. : 1985). 96(2) : 784-91, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14715688
  • Mulkey DK, Henderson RA, Ritucci NA, Putnam RW, Dean JB. Oxidative stress decreases pHi and Na(+)/H(+) exchange and increases excitability of solitary complex neurons from rat brain slices. American journal of physiology. Cell physiology. 286(4) : C940-51, 2004. http://www.ncbi.nlm.nih.gov/pubmed/14668260
  • Dean JB, Mulkey DK, Garcia AJ, Putnam RW, Henderson RA. Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures. Journal of applied physiology (Bethesda, Md. : 1985). 95(3) : 883-909, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12909594
  • Mulkey DK, Henderson RA, Putnam RW, Dean JB. Pressure (< or=4 ATA) increases membrane conductance and firing rate in the rat solitary complex. Journal of applied physiology (Bethesda, Md. : 1985). 95(3) : 922-30, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12704095
  • Mulkey DK, Henderson RA, Putnam RW, Dean JB. Hyperbaric oxygen and chemical oxidants stimulate CO2/H+-sensitive neurons in rat brain stem slices. Journal of applied physiology (Bethesda, Md. : 1985). 95(3) : 910-21, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12704094
  • Dean JB, Ballantyne D, Cardone DL, Erlichman JS, Solomon IC. Role of gap junctions in CO(2) chemoreception and respiratory control. American journal of physiology. Lung cellular and molecular physiology. 283(4) : L665-70, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12225940
  • Solomon IC, Dean JB. Gap junctions in CO(2)-chemoreception and respiratory control. Respiratory physiology & neurobiology. 131(3) : 155-73, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12126918

Positions Held

  • Vice-Chair of Administration and Professor (Department of Anatomy and Physiology, School of Medicine, Wright State University 2005 - 2006)
  • Director (Environmental & Hyperbaric Cell Biology Facility, Wright State University 2000 - 2006)
  • Acting-Chair and Professor (Dept. of Anatomy and Physiology, School of Medicine, Wright State University 2003 - 2004)
  • Professor (Department of Physiology and Biophysics, School of Medicine, Wright State University 2002 - 2003)
  • Associate Professor (with tenure) (Department of Physiology and Biophysics, School of Med., Wright State University 1997 - 2002)
  • Assist. Professor (Department of Physiology and Biophysics, Wright State University 1991 - 1997)
  • Research Assist. Prof. (Dept. of Physiology, Univ. of North Carolina 1991 - 1991)

Awards/Honors

  • Faculty Excellence Award Winner (SW Ohio Council for Higher Education - 2004)
  • Brage Golding Distinguished Professor of Research (Wright State University - 2003)
  • Award for Outstanding Excellence in Research and Medical Education (Wright State University, School of Medicine - 1999)
  • Clifford W. Perry Award (UNC-CH) (North Carolina Affiliate American Lung Association Grant-in-Aid of Research - 1990)
  • Presidential Predoctoral Fellow (Ohio State University - 1984)