MS, Medical Sciences/Biochemistry, University of South Florida, 1992
Interdisciplinary and Emerging Signature Programs
Cancer Biology
Research Interests
Current research projects focus on the process of palmitoylation, a post-translational lipid modification that plays an important role in stability and trafficking of several important proteins such as Ras, as well as other proteins responsible for a variety of human diseases.
Recent Publications
Haines RJ, Corbin KD, Pendleton LC, Meininger CJ, Eichler DC. Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function.Biochemical and biophysical research communications. 421(1) : 9-14, 2012.
Haines RJ, Corbin KD, Pendleton LC, Eichler DC. Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.The Journal of biological chemistry. 287(31) : 26168-76, 2012.
Pilon-Thomas S, Nelson N, Vohra N, Jerald M, Pendleton L, Szekeres K, Ghansah T. Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function.PloS one. 6(11) : e27729, 2011.
Haines RJ, Pendleton LC, Eichler DC. Argininosuccinate synthase: at the center of arginine metabolism.International journal of biochemistry and molecular biology. 2(1) : 8-23, 2011.
Corbin KD, Pendleton LC, Solomonson LP, Eichler DC. Phosphorylation of argininosuccinate synthase by protein kinase A.Biochemical and biophysical research communications. 377(4) : 1042-6, 2008.
Goodwin BL, Corbin KD, Pendleton LC, Levy MM, Solomonson LP, Eichler DC. Troglitazone up-regulates vascular endothelial argininosuccinate synthase.Biochemical and biophysical research communications. 370(2) : 254-8, 2008.
Goodwin BL, Pendleton LC, Levy MM, Solomonson LP, Eichler DC. Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells.American journal of physiology. Heart and circulatory physiology. 293(2) : H1115-21, 2007.
Pendleton LC, Goodwin BL, Solomonson LP, Eichler DC. Regulation of endothelial argininosuccinate synthase expression and NO production by an upstream open reading frame.The Journal of biological chemistry. 280(25) : 24252-60, 2005.
Ness GC, Pendleton LC, McCreery MJ. Target size analysis by radiation inactivation: the use of free radical scavengers.Experimental biology and medicine (Maywood, N.J.). 230(7) : 455-63, 2005.
Solomonson LP, Flam BR, Pendleton LC, Goodwin BL, Eichler DC. The caveolar nitric oxide synthase/arginine regeneration system for NO production in endothelial cells.The Journal of experimental biology. 206(Pt 12) : 2083-7, 2003.
Pendleton LC, Goodwin BL, Flam BR, Solomonson LP, Eichler DC. Endothelial argininosuccinate synthase mRNA 5''-untranslated region diversity. Infrastructure for tissue-specific expression.The Journal of biological chemistry. 277(28) : 25363-9, 2002.
