CONCLUSIONS: These findings identify trophoblast IL-1RAP as an amplifier of IL-1β-mediated inflammatory signaling and support further investigation of IL-1RAP in inflammation-associated preterm birth.

Gerstmann-Straussler-Scheinker (GSS) disease is a rare hereditary autosomal dominant prion disease characterized by cerebellar ataxia, dysarthria, and progressive dementia. We report a case of GSS disease in a 46-year-old patient who presented with four to six months of ataxia, dysarthria, intermittent tongue biting, and frontal headaches. His DaTscan (dopamine transporter scan) showed absent dopamine uptake in the left putamen and mildly decreased activity in the right putamen, a finding that..

Gastroparesis, a chronic motility disorder, is a diagnosis of exclusion that necessitates careful evaluation for structural and surgically correctable causes. Although the medical differential diagnosis emphasizes functional etiologies, anatomic abnormalities are often under-recognized despite guideline recommendations for thorough endoscopic and structural assessment. Symptoms such as nausea, vomiting, early satiety, and delayed gastric emptying may be indistinguishable from true motility...

CONCLUSIONS: In summary, participants generally reported high likelihood of recommending the HPV vaccine, with recommendations differing very little by patient sex, sexual orientation, or gender identity.