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Fellowships & Internships

* (Pediatric Allergy Fellowship Profile)

Larry Dishaw, PhD A-9930-2010

Larry Dishaw, PhD

Assoc Professor, College of Medicine Molecular Medicine

Associate Professor, College of Medicine Pediatrics

Contact Info


  • PhD, Biological Sciences, Florida International University, 2002
  • BS, Biology, Florida International University, 1997


Dr. Dishaw is an associate professor in the Morsani College of Medicine. His main research, using non-traditional animal models, focuses on characterizing novel forms of innate immunity and the molecular phylogeny of immune responses in the gut. His long-term objectives utilize genomics and transcriptomics approaches, as well as experimental biology, to study host-microbiome interactions. The Dishaw lab aims to define conserved phylogenic signals shaping the stability of microbial community dynamics at mucosal surfaces by investigating how host immunity and exogenous factors (like viruses that infect bacteria, or phages) of the gut ecosystem shape the microbiome. He works to reveal how this dynamic relationship at the mucosal surface of the gut relates to chronic health conditions such as Inflammatory Bowel Disease (IBD).


  • Member (American Association of Immunologists, 2014 - Present)
  • Member (American Society of Microbiologists, 2011 - Present)

Recent Publications

  • Groer MW, Miller EM, D''Agata A, Ho TTB, Dutra SV, Yoo JY, Yee AL, Gilbert JA, Dishaw LJ. Contributors to Dysbiosis in Very-Low-Birth-Weight Infants. Journal of obstetric, gynecologic, and neonatal nursing : JOGNN. , 2020.
  • Ho TTB, Kumar A, Louis-Jacques AF, Dishaw LJ, Yee AL, Groer MW. The development of intestinal dysbiosis in anemic preterm infants. Journal of perinatology : official journal of the California Perinatal Association. , 2020.
  • Yee AL, Miller E, Dishaw LJ, Gordon JM, Ji M, Dutra S, Ho TTB, Gilbert JA, Groer M. Longitudinal Microbiome Composition and Stability Correlate with Increased Weight and Length of Very-Low-Birth-Weight Infants. mSystems. 4(1) : e00229-18, 2019.
  • Liberti A, Cannon JP, Litman GW, Dishaw LJ. A Soluble Immune Effector Binds Both Fungi and Bacteria via Separate Functional Domains. Frontiers in immunology. 10(1) : 369, 2019.
  • Leigh BA, Breitbart M, Oksanen HM, Bamford DH, Dishaw LJ. Genome Sequence of PM2-Like Phage Cr39582, Induced from a Pseudoalteromonas sp. Isolated from the Gut of Ciona robusta. Genome announcements. 6(21) , 2018.
  • Leigh BA, Djurhuus A, Breitbart M, Dishaw LJ. The gut virome of the protochordate model organism, Ciona intestinalis subtype A. Virus research. 244: 137-146, 2018.
  • Liberti A, Zucchetti I, Melillo D, Skapura D, Shibata Y, De Santis R, Pinto MR, Litman GW, Dishaw LJ. Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis. Biology open. 7(1) , 2018.
  • Creasy A, Rosario K, Leigh BA, Dishaw LJ, Breitbart M. Unprecedented Diversity of ssDNA Phages from the Family Detected within the Gut of a Protochordate Model Organism (). Viruses. 10(8) , 2018.
  • Leigh B, Karrer C, Cannon JP, Breitbart M, Dishaw LJ. Isolation and Characterization of a Shewanella Phage-Host System from the Gut of the Tunicate, Ciona intestinalis. Viruses. 9(3) , 2017.
  • Dishaw LJ, Leigh B, Cannon JP, Liberti A, Mueller MG, Skapura DP, Karrer CR, Pinto MR, De Santis R, Litman GW. Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria. Nature Communications. 7: 10617, 2016.
  • Leigh BA, Liberti A, Dishaw LJ. Generation of Germ-Free Ciona intestinalis for Studies of Gut-Microbe Interactions. Frontiers in microbiology. 7: 2092, 2016.
  • Litman GW & Dishaw LJ. Early histocompatibility: color the mechanism green and red. Current Biology: CB. 25(21) : R1042-3, 2015.
  • Liberti A, Leigh B, De Santis R, Pinto MR, Cannon JP, Dishaw LJ, & Litman GW. An Immune Effector System in the Protochordate Gut Sheds Light on Fundamental Aspects of Vertebrate Immunity. Results and Problems in Cell Differentiation. 57: 159-73, 2015.
  • Fahsbender E, Rosario K, Cannon JP, Gulland F, Dishaw LJ, Breitbart M. Development of a Serological Assay for the Sea Lion (Zalophus californianus) Anellovirus, ZcAV. Scientific Reports. 5: 9637, 2015.
  • Zhang L, Li L, Guo X, Litman GW, Dishaw LJ, & Zhang G. Massive expansion and functional divergence of innate immune genes in a protostome. Scientific Reports. 5: 8693, 2015.
  • Dishaw LJ, Cannon JP, Litman GW, & Parker W. Immune-directed support of rich microbial communities in the gut has ancient roots. Developmental and Comparative Immunology. 47(1) : 36-51, 2014.
  • Groer MW, Luciano AA, Dishaw LJ, Ashmeade TL, Miller E, & Gilbert JA. Development of the preterm infant gut microbiome: a research priority. Microbiome. 2: 38, 2014.
  • Liberti A, Melillo D, Zucchetti I, Natale L, Dishaw LJ, Litman GW, De Santis R, & Pinto MR. Expression of Ciona intestinalis variable region-containing chitin-binding proteins during development of the gastrointestinal tract and their role in host-microbe interactions. PloS One. 9(5) : e94984, 2014.
  • Dishaw LJ, Flores-Torres J, Lax S, Gemayel K, Leigh B, Melillo D, Mueller MG, Natale L, Zucchetti I, De Santis R, Pinto MR, Litman GW, & Gilbert JA. The gut of geographically disparate Ciona intestinalis harbors a core microbiota. PloS One. 9(4) : e93386, 2014.
  • Litman GW & Dishaw LJ. Histocompatibility: clarifying fusion confusion. Current Biology: CB. 23(20) : R934-5, 2013.
  • Dishaw LJ & Litman GW. Changing views of the evolution of immunity. Frontiers in Immunology. 4: 122, 2013.
  • Dishaw LJ, Haire RN, & Litman GW. The amphioxus genome provides unique insight into the evolution of immunity. Briefings in Functional Genomics. 11(2) : 167-76, 2012.
  • Dishaw LJ, Flores-Torres JA, Mueller MG, Karrer CR, Skapura DP, Melillo D, Zucchetti I, De Santis R, Pinto MR, & Litman GW. A Basal chordate model for studies of gut microbial immune interactions. Frontiers in Immunology. 3: 96, 2012.
  • Dishaw LJ, Giacomelli S, Melillo D, Zucchetti I, Haire RN, Natale L, Russo NA, De Santis R, Litman GW, & Pinto MR. A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions. Proceedings of the National Academy of Sciences of the United States of America. 108(40) : 16747-52, 2011.
  • Dishaw LJ, Mueller MG, Haire RN, & Litman GW. Transfection-based genomic readout for identifying rare transcriptional splice variants. Methods in Molecular Biology (Clifton, N.J.). 748: 243-54, 2011.
  • Dishaw LJ, Ota T, Mueller MG, Cannon JP, Haire RN, Gwatney NR, Litman RT, & Litman GW. The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus. Immunogenetics. 62(9) : 623-31, 2010.
  • Cannon JP, Dishaw LJ, Haire RN, Litman RT, Ostrov DA, & Litman GW. Recognition of additional roles for immunoglobulin domains in immune function. Seminars in Immunology. 22(1) : 17-24, 2010.
  • Dishaw LJ, Litman GW. Invertebrate allorecognition: the origins of histocompatibility. Current biology : CB. 19(7) : R286-8, 2009.
  • Dorsey MJ, Petrovic A, Morrow MR, Dishaw LJ, Sleasman JW. FOXP3 expression following bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning. Immunologic research. 44(1-3) : 179-84, 2009.
  • Holland LZ, Albalat R, Azumi K, Benito-Gutiérrez E, Blow MJ, Bronner-Fraser M, Brunet F, Butts T, Candiani S, Dishaw LJ, Ferrier DE, Garcia-Fernàndez J, Gibson-Brown JJ, Gissi C, Godzik A, Hallböök F, Hirose D, Hosomichi K, Ikuta T, Inoko H, Kasahara M, Kasamatsu J, Kawashima T, Kimura A, Kobayashi M, Kozmik Z, Kubokawa K, Laudet V, Litman GW, McHardy AC, Meulemans D, Nonaka M, Olinski RP, Pancer Z, Pennacchio LA, Pestarino M, Rast JP, Rigoutsos I, Robinson-Rechavi M, Roch G, Saiga H, Sasakura Y, Satake M, Satou Y, Schubert M, Sherwood N, Shiina T, Takatori N, Tello J, Vopalensky P, Wada S, Xu A, Ye Y, Yoshida K, Yoshizaki F, Yu JK, Zhang Q, Zmasek CM, de Jong PJ, Osoegawa K, Putnam NH, Rokhsar DS, Satoh N, Holland PW. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome research. 18(7) : 1100-11, 2008.
  • Zhang Q, Zmasek CM, Dishaw LJ, Mueller MG, Ye Y, Litman GW, Godzik A. Novel genes dramatically alter regulatory network topology in amphioxus. Genome biology. 9(8) : R123, 2008.
  • Dishaw LJ, Mueller MG, Gwatney N, Cannon JP, Haire RN, Litman RT, Amemiya CT, Ota T, Rowen L, Glusman G, Litman GW. Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus. BMC genetics. 9: 78, 2008.
  • Litman GW, Dishaw LJ, Cannon JP, Haire RN, Rast JP. Alternative mechanisms of immune receptor diversity. Current opinion in immunology. 19(5) : 526-34, 2007.
  • Litman GW, Cannon JP, Dishaw LJ, Haire RN, Eason DD, Yoder JA, Prada JH, Ostrov DA. Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors. Immunologic research. 38(1-3) : 294-304, 2007.
  • Dishaw LJ, Herrera ML, Bigger CH. Characterization and phylogenetic analysis of a cnidarian LMP X-like cDNA. Immunogenetics. 58(5-6) : 454-64, 2006.
  • Litman GW, Cannon JP, Dishaw LJ. Reconstructing immune phylogeny: new perspectives. Nature reviews. Immunology. 5(11) : 866-79, 2005.
  • Dishaw LJ, Smith SL, Bigger CH. Characterization of a C3-like cDNA in a coral: phylogenetic implications. Immunogenetics. 57(7) : 535-48, 2005.
  • Kozmik Z, Daube M, Frei E, Norman B, Kos L, Dishaw LJ, Noll M, Piatigorsky J. Role of Pax genes in eye evolution: a cnidarian PaxB gene uniting Pax2 and Pax6 functions. Developmental cell. 5(5) : 773-85, 2003.
  • Piatigorsky J, Norman B, Dishaw LJ, Kos L, Horwitz J, Steinbach PJ, Kozmik Z. J3-crystallin of the jellyfish lens: similarity to saposins. Proceedings of the National Academy of Sciences of the United States of America. 98(22) : 12362-7, 2001.