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Allergy and Immunology


The Division of Allergy and Immunology is actively engaged in basic and clinical research. The Allergy/Immunology Laboratory in the Children's Research Institute focuses on immune dysregulation, primary immunodeficiency diseases, inflammatory cytokines following exposure to marine toxins and studies of T cell responses to vaccines.

Translational and Basic Science Research in Immunology

Several faculty engage in translational and basic science research on the pathomechanisms, diagnostic and novel treatment strategies for immune dysregulation in primary immunodeficiencies.

Dr. Jolan Walter’s group focuses on T and B cell dysregulation and tolerance checkpoints in variants of severe combined immunodeficiencies (SCID) with mutation of the recombination activating gene (RAG) in human and animal studies. Translational studies include the genetics of autoimmune cytopenias and national genetic screen for WHIM (warts, hypogammaglobilinemia, infections and myelokathexis) syndrome. Our research team is committed to promote targeted therapies in primary immunodeficiencies and immune dysregulation and bone marrow transplant and gene therapy for variants of SCID and combined immunodeficiencies. 

Clinical Trials

Our Allergy & Immunology Division is actively engaged in a number of pharmaceutical Phase III and Phase IV clinical trails leading to FDA approval for new immunoglobulin produces (both IVIG and SCIg) or changes in packet insert labeling. Our Division is also involved with studies in food allergy research.

Recent Publications

Book Chapters: