Taylor-Clark Lab

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Taylor-Clark Lab

Funding

Overview

Our work has been funded by the National Institutes of Health (NIH), the American Heart Association and USF Health.


Current Funding

NIH/National Heart Lung and Blood Institute R01 Award

Mitochondrial reactive oxygen species induce airway sensory nerve activity (2013-2018). The major goal of this project is determine the mechanisms by which mitochondrial dysfunction and mitochondiral reactive oxygen species production increase sensory nerve activation and hyperexcitability. The Diversity Supplement of this parent R01 focuses on the mechanism of TRPA1 activation by electrophiles.

NIH/Commonfund OT2 Award

Functional mapping of peripheral and central circuits for airway protection and breathing (2016-2019). The major goal of this project is to map using tracing, electrophysiology and modeling the specific afferent and CNS neurons involved in airway defense.

American Heart Association Grant-in-aid award Cardiovascular disease-associated neuronal plasticity transforms pulmonary-cardiac reflexes to sympathoexcitation (2016-2018). The major goal of this project is to identify the reflex responses of irritant inhalation in cardiovascular diseases and to determine the contribution of specific autonomic nerves in such responses.

Previous Funding

NIH/National Heart Lung and Blood Institute K99/R00 award

Sensory C-Fibers in the Upper Airways (2008-2012).
The major goal of this project is to characterize the sensory innervation of the airways using state-of-the-art electrophysiological methodology. Particular focus is made on the role of TRPA1 and TRPV1 ion channels in the activation of noiceptive nerves and the mechanisms by which allergen-associated mediators histamine and LTD4 modulate nociceptive nerve excitability.