Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

Due dates: June 2, 2025; July 2, 2025; February 2, 2026
Amount: The application budget must not exceed $350,000 in direct costs per year.
Relevance to microbiomes: The National Cancer Institute (NCI) supports research on the microbiome's role in cancer, particularly the effects of pre/probiotics on cancer prevention, interception, progression, and treatment.

The Division of Cancer Biology is interested in basic and mechanistic studies on how probiotics affect tumor formation at the molecular level and the interactions between probiotics, host cells, and the resident microbiome. It focuses on how these interactions influence cellular signaling, physiology, and metabolism.

The Office of Research on Women's Health is interested in supporting projects focused on accelerating precision probiotic interventions for specific women's health conditions across the lifespan, including but not limited to reproductive health, pregnancy, postpartum health, lactation, vaginal microbiome (bacterial vaginosis), menopause-related symptoms, and autoimmune disorders that are more prevalent in women.

For more information:  https://grants.nih.gov/grants/guide/pa-files/PAR-25-210.html

NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)

Due dates: June 5, 2025; July 5, 2025; September 7, 2025; October 5, 2025; November 5, 2025; January 7, 2026; February 5, 2026; March 5, 2026; May 7, 2026
Relevance to microbiomes: “Applications of cohort studies assessing associations of psychosocial and behavioral factors with -omics changes (including epigenetic modifications to the human genome and/or oral microbiome alterations) and impact of the associations upon oral diseases and conditions; Applications of cohort studies that analyze interaction of the human genome and oral microbiome in response to environmental stimuli and impact of the interaction on oral diseases and conditions.”
For more information: https://grants.nih.gov/grants/guide/pa-files/PAR-25-239.html

Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Not Allowed)

Due Dates: June 5, 2025; July 5, 2025; October 5, 2025; November 5, 2025; February 5, 2026; March 5, 2026
Amount: Application budgets are limited to $499,000 (direct costs) per year.
Relevance to microbiomes: “For analysis of exposures, including environmental and chemical exposures, and cancer-relevant microbiome and virome; host-microbiome interactions, and tools for gene-environment interaction”.
For more information: https://grants.nih.gov/grants/guide/pa-files/PAR-25-338.html

Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)

Due Date(s): June 5, 2025, July 5, 2025; October 5, 2025, November 5, 2025, February 5, 2025, March 5, 2025

Amount: “The direct costs for any year may not exceed $250,000 (excluding consortium F&A costs). Within that limit, applications need to reflect the actual needs of the proposed project”.
Relevance to microbiomes: Evaluation of cancer risk associated with exogenous (e.g., chemical agents, infectious agents, radiation, medication, nutrition, tobacco, and drug use) and endogenous (e.g., metabolome, microbiome, adductome) factors, mixtures and interaction of these factors, and effects during early life and critical periods across the life course.
For more information: https://grants.nih.gov/grants/guide/pa-files/PA-25-172.html

Exploratory Grants in Cancer Control (R21 Clinical Trial Optional)

Due Date(s): June 16, 2025, July 16, 2025, September 7, 2025, October 16, 2025, November 16, 2025, January 7, 2025
Amount: “The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in a single year”.
For more information: https://grants.nih.gov/grants/guide/pa-files/PA-25-253.html

NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)

Due Dates: June 23, 2025; July 17, 2025; February 23, 2026; March 17, 2026
Relevance to microbiomes: Research interests include: Studies that examine the effects of prebiotics/probiotics and other natural products on gut microbiome-brain interactions. Of particular interest are studies of prebiotics/probiotics for depression, anxiety disorders, irritable bowel syndrome (IBS), or chronic pain. Link: https://grants.nih.gov/grants/guide/pa-files/PAR-25-270.html

Notice of Special Interest (NOSI): Chronic Inflammation of the Oral Cavity - An Agent for Oral Mucosal Disease

Due Date: This notice applies to due dates on or after February 5, 2024, and subsequent receipt dates through September 7, 2026.  For more information: NOT-DE-23-007: Notice of Special Interest (NOSI): Chronic Inflammation of the Oral Cavity - An Agent for Oral Mucosal Disease (nih.gov)

Notice of Special Interest (NOSI): Leveraging Microbial Exposure for Improving Mouse Models of Human Immunity

Due date: November 16, 2027
Relevance to microbiomes: Research interests include “Applications of cohort studies assessing associations of psychosocial and behavioral factors with -omics changes (including epigenetic modifications to the human genome and/or oral microbiome alterations) and impact of the associations upon oral diseases and conditions; Applications of cohort studies that analyze interaction of the human genome and oral microbiome in response to environmental stimuli and impact of the interaction on oral diseases and conditions.”
For more information: https://grants.nih.gov/grants/guide/notice-files/NOT-AI-24-078.html

Plant Biotic Interactions

Notice Number: NSF 18-590
Due Date: Continuous
Approximate Funding Amount: $18,500,000 depending on availability of funds$10.5M from NSF for new standard or continuing grant awards, and approximately $8M from USDA/NIFA for new awards. Both estimates depend on availability of appropriations. USDA/NIFA will support projects for up to four years in duration. Although there are no formal upper or lower limits to award amounts, they typically range from $50,000 to $300,000 per year, with durations of two to four years (and five years for CAREER awards). Enactment of additional continuing resolutions or an appropriations act may affect the availability or level of funding for this program.
For more information:   https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=505267 

Transitions to Excellence in Molecular and Cellular Biosciences Research (Transitions) 

Notice Number: NSF 21-508
Due Date: Continuous
Anticipated Funding Amount: $6,000,000 Pending availability of funds
For more information: https://www.nsf.gov/pubs/2021/nsf21508/nsf21508.htm

Physiological and Structural Systems (PSS)

Due Date: Continuous
For more information: https://beta.nsf.gov/funding/opportunities/physiological-structural-systems-pss

US Army Combat Capabilities Development Command Broad Agency Announcement

Issued by: Department of Defense
Due Date(s): Feb 28, 2025
Funding Opportunity Number: W911QY20R0022
For more information: https://www.grants.gov/web/grants/view-opportunity.html?oppId=327285

Biocodex Microbiota Foundation - Call for Projects USA

Sponsor: Biocodex Microbiota Foundation
Due Date: The Deadline to apply is May 23, 2025. One grant will be awarded, and the recipient will be notified by July 31, 2025.
Amount: $50,000
Link: https://www.biocodexmicrobiotafoundation.com/national-research-grant/call-projects-usa

American Gastroenterological Association Grants

Due Date: Varies
For list of Grants: https://gastro.org/research-and-awards/apply-for-awards/  

American Society of Transplantation Research Grants

Due Dates: Varies
For more information: https://www.myast.org/research/research-grant-opportunities    

Crohn’s & Colitis Foundation Grants & Fellowships

Due Dates: Varies
For more information: https://www.crohnscolitisfoundation.org/research/grants-fellowships

Investigator - Initiated Studies + Educational Grants - Bausch & Lomb

Due Date: Continuous
For more information: https://www.bausch.com/product-innovation/independent-research-cme-grants/

AbbVie - Investigator-Initiated Studies

Due Date: Continuous
For more information: https://www.abbvie.com/science/clinical-trials/investigator-initiated-studies.html

US Forest Service (USFS) Postdoctoral Fellowship for the Integration of Microbiome, Disease, and Climate Factors Associated with Southern Pine Species

Due Date: Applications will be reviewed on a rolling-basis.
Location: US Department of Agriculture (USDA) Forest Service (USFS) within the Rocky Mountain Research Station (RMRS) located in Fort Collins, Colorado.
For more information:  https://www.zintellect.com/Opportunity/Details/USDA-USFS-SRS-2024-0153

U.S. Department of Agriculture (USDA) - Agricultural Research Service (ARS) Postgraduate Fellowship in Foodborne Pathogen Research

Due Date: Applications will be reviewed on a rolling-basis.
Location: U.S. Department of Agriculture (USDA), Agricultural Research Service (ARS), National Animal Disease Center (NADC), Food Safety and Enteric Pathogens Research Unit located in Ames, Iowa. Relocation will be required.
For more information:  https://www.zintellect.com/Opportunity/Details/USDA-ARS-MW-2024-0125

U.S. Department of Agriculture (USDA)- Agricultural Research Service (ARS) Undergraduate Student Internship in Bioinformatics

Due Date: Applications may be reviewed on a rolling-basis, and this posting will remain open until a qualified candidate is identified.
Location: A research opportunity in Bioinformatics is available with the U.S. Department of Agriculture (USDA), Agricultural Research Service (ARS), Sustainable Agriculture Systems Laboratory in Beltsville, Maryland.
For more information:  https://www.zintellect.com/Opportunity/Details/USDA-ARS-2022-0054

U.S. Food and Drug Administration (FDA) Fellowship in Microbiome and Infectious Disease

Due Date: Applications will be reviewed on a rolling-basis, and this posting will remain open until filled.
Location: Laboratory of Dr. Paul Carlson in the Office of Vaccines Research and Review (OVRR) at the Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA) in Silver Spring, Maryland
For more information: https://www.zintellect.com/Opportunity/Details/FDA-CBER-2022-17

Nutrition and Human Performance Fellowship at the U.S. Army Research Institute of Environmental Medicine (USARIEM)

Location: Natick, Massachusetts
Due Date: Applications are reviewed on an ongoing basis and fellowships will be filled as qualified candidates are identified.
For more information: https://www.zintellect.com/Opportunity/Details/USAMRDC-RIEM-2022-0037

USDA-ARS Postdoctoral Research Fellowship in Plant Pathology

Due Date: Applications are reviewed on a rolling-basis.
Location: U.S. Department of Agriculture (USDA), Agricultural Research Service (ARS), located in Fort Pierce, Florida.
For more information: Zintellect - Climb Higher

U.S. Department of Agriculture (USDA)-Agricultural Research Service (ARS) Fellowship Research Opportunity in Microbiology, Immunology, and Veterinary Science

Due Date: Applications are reviewed on a rolling-basis.
Location: U.S. Department of Agriculture (USDA), Agricultural Research Service (ARS), located in Ames, Iowa.
For more information: https://www.zintellect.com/Opportunity/Details/USDA-ARS-MW-2024-0135