Our research aims to better understand the cellular and molecular regulation of cardiovascular function in health and disease. We investigate the signaling mechanisms of cell-cell and cell-matrix interactions in the microcirculation during inflammation, trauma, infection, sepsis, atherosclerosis, diabetes, and metastatic tumor development. We utilize various techniques in these studies including intravital microscopy, 3D fluorescence imaging, fluorescence resonance energy transfer, electric cell-substrate impedance sensor, cell isometric tension, and state-of-the-art molecular approaches including gene knockout and mutation.