Thank you very much for your interest in our research! The main goal of research in our laboratory is to identify molecular targets for new therapeutic approaches, which are aimed to reduce secondary organ dysfunction and damage in critical illness. Since several years, we have focused our research on novel aspects in the regulation of G protein-coupled receptors which are essential during the cardiovascular stress response and during acute and chronic inflammation.
Our approach is clinically oriented, integrative and translational in nature. Utilizing initial observations in patients to develop novel hypotheses, we establish cell systems to determine underlying molecular mechanisms, which are then probed for therapeutic applicability in in vivo models to provide proof of concept, followed by rigorous preclinical efficacy testing to enable transition towards clinical applicability.