The main goal of research in our laboratory is to define molecular mechanisms involved in microvascular remodeling in brain and peripheral circulation during inflammation. Lately our lab has focused on problems related to vascular cognitive impairment, particularly, on effects of elevated blood level of fibrinogen mediating neuronal degeneration and the resultant short-term memory reduction during mild to moderate traumatic brain injury. As the main line of research that is centered on traumatic brain injury-caused pathologies is a part of overall inflammation-induced vascular alterations, which take place in whole cardiovascular system, changes in molecular mechanisms resulting in vascular remodeling during pathologies such as hypertension, diabetes, and stroke are also interests of the group.