Neurology

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Neuromuscular

Muscle weakness is one of the key symptoms in the early detection and diagnosis of neuromuscular disorders, but there are other symptoms, like double vision, challenges with breathing and speech, trouble swallowing, and muscle twitching that you might not connect with neuromuscular concerns. Patients experience these symptoms when nerve cells (motor neurons) become unhealthy and the nervous system is no longer able to communicate with our muscles.


As an academic medical center, USF Health has the board certified physicians and advanced diagnostic techniques to diagnose patients with nerve and muscle diseases at all levels of complexity. We provide patients access to electromyography and nerve conduction studies (EMG and NCS), a complex test critical to making an accurate neuromuscular disorder diagnosis.  On the cutting edge of diagnostic technology, our facilities are also designed with patient comfort and convenience in mind.

We care for patients with these Neuromuscular Conditions:
  • Amyotrophic lateral sclerosis (ALS)
  • Primary lateral sclerosis
  • Progressive muscular atrophy
  • Spinal bulbar muscular atrophy
  • Spinal muscular atrophy
  • Charcot-Marie Tooch disease
  • Myasthenia gravis 
  • Chronic inflammatory demyelinating polyneuropathy (CIDP)
  • Plexopathy
  • Multifocal motor neuropathy (MMN)
  • Diabetic neuropathy
  • Carpal tunnel syndrome
  • Entrapment neuropathies 
  • Lambert-Eaton myasthenic syndrome
  • Polymyositis
  • Dermatomyositis 
  • Inclusion-body myositis
  • Muscular dystropies

We provide patients with these treatment options for Neuromuscular conditions:
  • Radiculopathy
  • Botox
  • Electromyography (EMG)
  • Single fiber EMG
  • EMG-guided Botox
  • Lumbar punctures
  • Intravenous immunoglobulin treatment – gamma globulin (IVIG) 
  • Skin and muscle biopsies

USF Health ALS Clinic

USF Health is home to this region’s flagship ALS Center, offering patients and their families a multidisciplinary care team that puts ALS patients at the center of care, helping them to better manage their symptoms. Our devoted neurologists, occupational and physical therapists, speech pathologists, dieticians, respiratory therapists, and social workers, come together to provide patients with targeted, integrated care. Pulmonologists, gastroenterologists and psychiatrists are also available for consultation, as needed. Patients, their families and caregivers seen at the ALS Clinic have the opportunity to meet with all members of the ALS care team – all in one carefully coordinated visit. 


Clinical Trials - Neuromuscular

The purpose of the study is to evaluate the safety and efficacy of RA101495 in patients with Paroxysmal Nocturnal Hemoglobinuria (PNH). There will be two groups of patients in the study: the first group will include patients who have never received eculizumab for treatment of PNH. The second group will include patients who have received treatment with eculizumab for at least 6 months prior to the study. Patients will be treated with RA101495 for 12 weeks. 

For more information please visit the website at:  https://clinicaltrials.gov/ct2/show/NCT03078582

To enroll in this study at USF please contact Brittany Harvey at 813-974-9413

Octagam is a human normal immunoglobulin (IGIV) solution for intravenous administration. Octagam 5% is currently registered in more than 60 countries. This study will evaluate the efficacy, safety and the kinetics of Octagam 10% for replacement therapy in primary immunodeficiency diseases.

For more information please visit the website at:  https://clinicaltrials.gov/ct2/show/NCT00811174 

To enroll in this study at USF please contact Brittany Harvey at 813-974-9413

Clinical Trials - ALS

Amx0035 patients with Amyotrophic Lateral Sclerosis (ALS) (CENTAUR).  The CENTAUR trial will be a 2:1 (active:placebo) randomized, double-blind, placebo-controlled Phase II trial to evaluate the safety and efficacy of AMX0035 for the treatment of ALS.

For more information please visit the website at:  https://clinicaltrials.gov/ct2/show/NCT03127514 

To enroll in this study at USF please contact Brittany Harvey at 813-974-9413

A study to evaluate the efficacy, safety, and tolerability of CK-2127107 in patients with Amyotrophic Lateral Sclerosis. (FORTITUDE-ALS).

For more information please visit the website at:  https://clinicaltrials.gov/ct2/show/NCT03160898

To enroll in this study at USF please contact Brittany Harvey at 813-974-9413

A study to assess the efficacy and safety of H.P. Acthar Gel in the treatment of subjects with Amyotrophic Lateral Sclerosis.

For more information please visit the website at:  https://clinicaltrials.gov/ct2/show/NCT03068754

To enroll in this study at USF please contact Brittany Harvey at 813-974-9413

Effects of oral Levosimendan (ODM-109) on respiratory function in patients with ALS.

For more information please visit the website at:  https://clinicaltrials.gov/ct2/show/NCT02487407

To enroll in this study at USF please contact Brittany Harvey at 813-974-9413