American Heart Association
The major goals of these projects are to develop animal models of health differences to help us know how these might affect stroke outcomes and stroke recovery and likely helpful approaches. Our goals are to help realize the ways linked with health differences in order to be able to decide ways to treat these individuals.

Department of Veterans Affairs
Dr. Kindy is a Senior Research Career Scientist (SRCS) in the VA and receives salary to allow him to dedicate his time to the research program. In addition, we are studying the impact of inflammation in both Alzheimer’s disease and stroke with a focus on targeting specific proteins for therapeutics. Novel vaccines, immunotherapies, antisense oligonucleotide treatments, etc.

Florida Department of Health Ed and Ethel Moore Alzheimer’s Disease Research Program
Alzheimer’s disease (AD) affects ~35% of people over the age of 85, but the pathogenesis of late-onset AD is obscure. As for AD and type 2 diabetes mellitus (T2DM) or pre-T2DM, it is speculated that insulin resistance increases AD susceptibility. The goal of this proposal is a collaborative effort between the University of South Florida (Kindy) and the Moffitt Cancer Center (McDonald) to test the efficacy of novel glucagon-like peptide-1 receptor (GLP-1R) agonists (P5 and brain-penetrant derivatives) both in vitro and in vivo to determine their efficacy in attenuation of AD.

National Institutes of Health (National Institutes on Aging)
Current guidelines for the treatment of patients suffering from terminal restlessness call for the use of a combination of opioids, antipsychotics, and benzodiazepines. Unfortunately there is only very limited data supporting this approach. This trial (LiBBY) proposes the use of cannabinoids for the treatment of this condition in Alzheimer’s patients. The expected outcome will provide an alternative approach that could improve the quality of end of life and reduce distress for patients in the last days of their lives.

Multidisciplinary Association for Psychedelic Studies (MAPS)
The present study proposal aims to examine the use of inhaled cannabis containing High THC against placebo for treatment of PTSD among 360 veterans in an outpatient setting with a parallel design and methods to mitigate placebo response.

Department of Veterans Affairs
Targeted Delivery of Antioxidant Drugs Following Cerebral Ischemic Injury – this project focused on the development of nanoparticles to deliver antioxidant drugs to the brain following stroke.

National Institutes of Health (National Institutes on Environmental Health and Safety)
Pesticides, Paraoxonase, and Alzheimer’s Disease – this project examined the early exposure of animal models of AD to determine the long-term effects on development of age-related diseases.

National Institutes of Health (National Institutes on Aging)
Role of Fibulin1 in Amyloid Precursor Protein Processing – The overall goal of this project is to determine the role of fibulin-1 (Fbln1) in the pathogenic process of Alzheimer's disease (AD) and other neurodegenerative diseases. The experimentation will test the hypothesis that Fbln1 interacts with the amyloid precursor protein (APP) to regulate proteolytic processing events associated with AD. The experimentation will also determine if Fbln1 is a potential target for therapeutic intervention in AD.

National Institutes of Health (National Institutes of General Medical Sciences)
SC COBRE for Developmentally Based Cardiovascular Diseases - Three underlying themes define the Center's research: understanding mechanisms of normal and abnormal heart and vascular development; investigating the developmental basis of adult cardiovascular diseases; and applying the principles of normal cardiovascular developmental biology to regenerative medicine or stem cell-based, tissue engineering.