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Priscilla Amofa-Ho


The NEST Lab explores combinations of lifestyle and behavioral interventions – Cognitive Behavioral Therapy for Insomnia (CBTi), physical activity, diet/nutrition, cognitive training and compensatory strategies, and supportive therapy – to target multiple risk factors for Alzheimer’s disease and related dementias and to improve cognition, vascular health, everyday functioning, mood, and overall health outcomes. We also explore these interventions to improve cognition among adults and older adults at increased risk of cognitive decline or impairment. Translational tools, including neuroimaging and health-monitoring wearables, and interdisciplinary approaches are used to inform intervention adaptation and optimize effects on cognition and everyday functioning.

The NEST Lab focuses on three core areas:

Areas of Interest

Alzheimer’s Disease and Related Dementias (ADRD); lifestyle and behavioral (non-pharmacological) interventions; cardiometabolic diseases; cerebrovascular disease; multimorbidity; health disparities; determinants of health; mild cognitive impairment (MCI).  

Research Team

Principal Investigator/ Lab Director

Dr. Priscilla Amofa-Ho is an Assistant Professor (tenure-track) and a clinical neuropsychologist (PY 13213). She leads the Neurocognitive Enhancement through Synergistic Therapies (NEST) Lab. Dr. Amofa-Ho completed her doctoral training in Clinical Neuropsychology at the University of Florida in Gainesville. Before earning her PhD, she worked at the Rush Alzheimer’s Disease Research Center on various intervention studies aimed at reducing the risk of Alzheimer’s disease dementia and other dementias. She completed her postdoctoral fellowship at the University of South Florida (PI: Dr. Christina McCrae, PhD, DBSM, FSBSM, FAASM, director of the SHINE Science Center and Assistant Dean of Research), focusing on how sleep affects cognitive aging and neurodegenerative disorders.

Dr. Amofa-Ho has extensive training and experience working with individuals at risk of and with dementia. Her clinical and research interests include mild cognitive impairment (MCI), dyadic interventions, dementias, the role of psychosocial factors and determinants of health in cognitive aging, implementing interventions to prevent cognitive decline, and adapting interventions for underserved populations.

Her current research focuses on adapting multimodal lifestyle interventions for remote delivery to persons with MCI and their family caregivers. She is also interested in using lifestyle and non-pharmacological interventions to reduce cognitive decline and poor health outcomes among persons undergoing cancer treatment, those with high multimorbidity, and in culturally sensitive adaptation of interventions for underrepresented populations at increased risk of ADRD. 

Trainee Recruitment

The NEST Lab is seeking trainees/volunteers/medical students with experience in REDCap to assist in building online databases to support data collection for upcoming projects. Interested personnel should reach out to Dr. Amofa-Ho at priscillaamofaho@usf.edu.

The Lab is also seeking undergraduate/medical students interested in brain aging, Alzheimer’s disease and related dementias (ADRD), ADRD biomarkers, and lifestyle interventions to improve cognition and functioning. Individuals with strengths in patient-centered research, research recruitment, data analysis (including sleep and neuroimaging), and strong statistical skills are encouraged to reach out to Dr. Amofa-Ho with their CV at priscillaamofaho@usf.edu. Students interested in the lab's focus, even without experience, are also encouraged to reach out to Dr. Amofa-Ho.

The lab is also looking for volunteers with strong communication and media backgrounds to help translate and spread the many works coming out of the lab. Interested personnel should reach out to Dr. Amofa-Ho at priscillaamofaho@usf.edu.