USF Heart Institute

Ganesh Halade

Ganesh Halade, PhD

Associate Professor, College of Medicine Internal Medicine

Contact Info 560 Channelside Drive
Tampa FL 33602

Academic Email: ghalade@usf.edu

Academic Phone:(813) 396-0104

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cardiovascular Sciences
  • Cellular and Molecular Biology
  • Metabolic Regulation and Disorders

Research Interests

  • Research objective is to determine on how unresolved chronic inflammation and immune responsive metabolic dysregulation contributes to ischemic and non-ischemic heart failure.
  • Halade lab research focuses on 1) study of heart failure etiology with an integrative approach focusing on splenic leukocytes and heart; 2) measurement of inflammatory mediators that impair cardiac repair and resolving lipid mediators that facilitate cardiac repair after heart attack; 3) role of resolution receptor in inflammation-resolution processes in heart failure; and 4) translate our findings for use in human therapy, considering risk factors such as obesity, diabetes, aging, and co-medications (oncological drugs).

Recent Publications

  • Heaberlin JR, Ma Y, Zhang J, Ahuja SS, Lindsey ML, Halade GV. Obese and diabetic KKAy mice show increased mortality but improved cardiac function following myocardial infarction. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 22(6) : 481-7http://www.ncbi.nlm.nih.gov/pubmed/23896047
  • Halade GV, Black LM, Verma MK. Paradigm shift - Metabolic transformation of docosahexaenoic and eicosapentaenoic acids to bioactives exemplify the promise of fatty acid drug discovery. Biotechnology advances. 36(4) : 935-953http://www.ncbi.nlm.nih.gov/pubmed/29499340
  • Rahman M, Halade GV, Bhattacharya A, Fernandes G. The fat-1 transgene in mice increases antioxidant potential, reduces pro-inflammatory cytokine levels, and enhances PPAR-gamma and SIRT-1 expression on a calorie restricted diet. Oxidative medicine and cellular longevity. 2(5) : 307-16http://www.ncbi.nlm.nih.gov/pubmed/20716918
  • Halade GV, Kain V, De La Rosa X, Lindsey ML. Metabolic transformation of fat in obesity determines the inflammation resolving capacity of splenocardiac and cardiorenal networks in heart failure. American journal of physiology. Heart and circulatory physiology. 322(6) : H953-H970, 2022. http://www.ncbi.nlm.nih.gov/pubmed/35333119
  • Zhou Q, Doherty J, Akk A, Springer LE, Fan P, Spasojevic I, Halade GV, Yang H, Pham CTN, Wickline SA, Pan H. Safety Profile of Rapamycin Perfluorocarbon Nanoparticles for Preventing Cisplatin-Induced Kidney Injury. Nanomaterials (Basel, Switzerland). 12(3) , 2022. http://www.ncbi.nlm.nih.gov/pubmed/35159680
  • Kain V, Mat Y, Halade GV. Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation. GeroScience. 44(3) : 1689-1702, 2022. http://www.ncbi.nlm.nih.gov/pubmed/34932185
  • Kain V, Halade GV. Dysfunction of resolution receptor triggers cardiomyopathy of obesity and signs of non-resolving inflammation in heart failure. Molecular and cellular endocrinology. 542: 111521, 2022. http://www.ncbi.nlm.nih.gov/pubmed/34843898
  • Halade GV, Lee DH. Inflammation and resolution signaling in cardiac repair and heart failure. EBioMedicine. 79: 103992, 2022. http://www.ncbi.nlm.nih.gov/pubmed/35405389
  • Carris NW, Mhaskar R, Coughlin E, Bracey E, Tipparaju SM, Halade GV. Novel biomarkers of inflammation in heart failure with preserved ejection fraction: analysis from a large prospective cohort study. BMC cardiovascular disorders. 22(1) : 221, 2022. http://www.ncbi.nlm.nih.gov/pubmed/35568817
  • Heather LC, Hafstad AD, Halade GV, Harmancey R, Mellor KM, Mishra PK, Mulvihill EE, Nabben M, Nakamura M, Rider OJ, Ruiz M, Wende AR, Ussher JR. Guidelines on models of diabetic heart disease. American journal of physiology. Heart and circulatory physiology. 323(1) : H176-H200, 2022. http://www.ncbi.nlm.nih.gov/pubmed/35657616
  • Kozlovskaya V, Yang Y, Liu F, Ingle K, Ahmad A, Halade GV, Kharlampieva E. Dually Responsive Poly(-vinylcaprolactam)--poly(dimethylsiloxane)--poly(-vinylcaprolactam) Polymersomes for Controlled Delivery. Molecules (Basel, Switzerland). 27(11) , 2022. http://www.ncbi.nlm.nih.gov/pubmed/35684423
  • Tourki B, Halade GV. Heart Failure Syndrome With Preserved Ejection Fraction Is a Metabolic Cluster of Non-resolving Inflammation in Obesity. Frontiers in cardiovascular medicine. 8: 695952, 2021. http://www.ncbi.nlm.nih.gov/pubmed/34409075
  • Gottlieb LA, Larsen K, Halade GV, Young ME, Thomsen MB. Prolonged QT intervals in mice with cardiomyocyte-specific deficiency of the molecular clock. Acta physiologica (Oxford, England). 233(1) : e13707, 2021. http://www.ncbi.nlm.nih.gov/pubmed/34176211
  • Lindsey ML, de Castro Brás LE, DeLeon-Pennell KY, Frangogiannis NG, Halade GV, O'Meara CC, Spinale FG, Kassiri Z, Kirk JA, Kleinbongard P, Ripplinger CM, Brunt KR. Reperfused vs. nonreperfused myocardial infarction: when to use which model. American journal of physiology. Heart and circulatory physiology. 321(1) : H208-H213, 2021. http://www.ncbi.nlm.nih.gov/pubmed/34114891
  • Cugno C, Kizhakayil D, Calzone R, Rahman SM, Halade GV, Rahman MM. Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging C57BL/6 mice and in vitro studies. Scientific reports. 11(1) : 10364, 2021. http://www.ncbi.nlm.nih.gov/pubmed/33990655
  • Tourki B, Black LM, Kain V, Halade GV. Lipoxygenase inhibitor ML351 dysregulated an innate inflammatory response leading to impaired cardiac repair in acute heart failure. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 139: 111574, 2021. http://www.ncbi.nlm.nih.gov/pubmed/33862495
  • Kain V, Ingle KA, Rajasekaran NS, Halade GV. Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice. Theranostics. 11(6) : 2742-2754, 2021. http://www.ncbi.nlm.nih.gov/pubmed/33456570
  • Lindsey ML, Brunt KR, Kirk JA, Kleinbongard P, Calvert JW, de Castro Brás LE, DeLeon-Pennell KY, Del Re DP, Frangogiannis NG, Frantz S, Gumina RJ, Halade GV, Jones SP, Ritchie RH, Spinale FG, Thorp EB, Ripplinger CM, Kassiri Z. Guidelines for in vivo mouse models of myocardial infarction. American journal of physiology. Heart and circulatory physiology. 321(6) : H1056-H1073, 2021. http://www.ncbi.nlm.nih.gov/pubmed/34623181
  • B Gowda S, Gowda D, Kain V, Chiba H, Hui SP, Chalfant CE, Parcha V, Arora P, Halade GV. Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts. American journal of physiology. Heart and circulatory physiology. 321(3) : H599-H611, 2021. http://www.ncbi.nlm.nih.gov/pubmed/34415189
  • Pal A, Al-Shaer AE, Guesdon W, Torres MJ, Armstrong M, Quinn K, Davis T, Reisdorph N, Neufer PD, Spangenburg EE, Carroll I, Bazinet RP, Halade GV, Clària J, Shaikh SR. Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(8) : 10640-10656, 2020. http://www.ncbi.nlm.nih.gov/pubmed/32579292
  • Tourki B, Kain V, Shaikh SR, Leroy X, Serhan CN, Halade GV. Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(8) : 10560-10573, 2020. http://www.ncbi.nlm.nih.gov/pubmed/32543720
  • Beno SM, Riegler AN, Gilley RP, Brissac T, Wang Y, Kruckow KL, Jadapalli JK, Wright GM, Shenoy AT, Stoner SN, Restrepo MI, Deshane JS, Halade GV, González-Juarbe N, Orihuela CJ. Inhibition of Necroptosis to Prevent Long-term Cardiac Damage During Pneumococcal Pneumonia and Invasive Disease. The Journal of infectious diseases. 222(11) : 1882-1893, 2020. http://www.ncbi.nlm.nih.gov/pubmed/32492702
  • Halade GV, Kain V, Dillion C, Beasley M, Dudenbostel T, Oparil S, Limdi NA. Race-based and sex-based differences in bioactive lipid mediators after myocardial infarction. ESC heart failure. 7(4) : 1700-1710, 2020. http://www.ncbi.nlm.nih.gov/pubmed/32363774
  • Pullen AB, Kain V, Serhan CN, Halade GV. Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice. Journal of the American Heart Association. 9(8) : e015672, 2020. http://www.ncbi.nlm.nih.gov/pubmed/32295449
  • Tourki B, Kain V, Pullen AB, Norris PC, Patel N, Arora P, Leroy X, Serhan CN, Halade GV. Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure. Molecular metabolism. 31: 138-149, 2020. http://www.ncbi.nlm.nih.gov/pubmed/31918915
  • Zhu Y, Shamblin I, Rodriguez E, Salzer GE, Araysi L, Margolies KA, Halade GV, Litovsky SH, Pogwizd S, Gray M, Huke S. Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse model. Human molecular genetics. 29(3) : 369-381, 2020. http://www.ncbi.nlm.nih.gov/pubmed/31816043
  • Kain V, Halade GV. Role of neutrophils in ischemic heart failure. Pharmacology & therapeutics. 205: 107424, 2020. http://www.ncbi.nlm.nih.gov/pubmed/31629005
  • Pullen AB, Jadapalli JK, Rhourri-Frih B, Halade GV. Re-evaluating the causes and consequences of non-resolving inflammation in chronic cardiovascular disease. Heart failure reviews. 25(2) : 381-391, 2020. http://www.ncbi.nlm.nih.gov/pubmed/31201605
  • Reid AL, Wang Y, Samani A, Hightower RM, Lopez MA, Gilbert SR, Ianov L, Crossman DK, Dell'Italia LJ, Millay DP, van Groen T, Halade GV, Alexander MS. DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies. Human molecular genetics. 29(17) : 2855-2871, 2020. http://www.ncbi.nlm.nih.gov/pubmed/32766788
  • Ilatovskaya DV, Halade GV, DeLeon-Pennell KY. Adaptive immunity-driven inflammation and cardiovascular disease. American journal of physiology. Heart and circulatory physiology. 317(6) : H1254-H1257, 2019. http://www.ncbi.nlm.nih.gov/pubmed/31702971
  • Kain V, Halade GV. Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment. Journal of cellular physiology. 234(4) : 3910-3920, 2019. http://www.ncbi.nlm.nih.gov/pubmed/30191990
  • Cai A, Dillon C, Hillegass WB, Beasley M, Brott BC, Bittner VA, Perry GJ, Halade GV, Prabhu SD, Limdi NA. Risk of Major Adverse Cardiovascular Events and Major Hemorrhage Among White and Black Patients Undergoing Percutaneous Coronary Intervention. Journal of the American Heart Association. 8(22) : e012874, 2019. http://www.ncbi.nlm.nih.gov/pubmed/31701784
  • Patel N, Russell GK, Musunuru K, Gutierrez OM, Halade G, Kain V, Lv W, Prabhu SD, Margulies KB, Cappola TP, Arora G, Wang TJ, Arora P. Race, Natriuretic Peptides, and High-Carbohydrate Challenge: A Clinical Trial. Circulation research. 125(11) : 957-968, 2019. http://www.ncbi.nlm.nih.gov/pubmed/31588864
  • Halade GV, Tourki B. Specialized Pro-resolving Mediators Directs Cardiac Healing and Repair with Activation of Inflammation and Resolution Program in Heart Failure. Advances in experimental medicine and biology. 1161: 45-64, 2019. http://www.ncbi.nlm.nih.gov/pubmed/31562621
  • Kain V, Halade GV. Gravin gravitates atherogenesis to atheroprogression in the obesogenic setting. American journal of physiology. Heart and circulatory physiology. 317(4) : H790-H792, 2019. http://www.ncbi.nlm.nih.gov/pubmed/31518153
  • Abou-Saleh H, Ouhtit A, Halade GV, Rahman MM. Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content. Nutrients. 11(11) , 2019. http://www.ncbi.nlm.nih.gov/pubmed/31717258
  • Kain V, Jadapalli JK, Tourki B, Halade GV. Inhibition of FPR2 impaired leukocytes recruitment and elicited non-resolving inflammation in acute heart failure. Pharmacological research. 146: 104295, 2019. http://www.ncbi.nlm.nih.gov/pubmed/31216426
  • Halade GV, Kain V, Tourki B, Jadapalli JK. Lipoxygenase drives lipidomic and metabolic reprogramming in ischemic heart failure. Metabolism: clinical and experimental. 96: 22-32, 2019. http://www.ncbi.nlm.nih.gov/pubmed/30999004
  • Kain V, Van Der Pol W, Mariappan N, Ahmad A, Eipers P, Gibson DL, Gladine C, Vigor C, Durand T, Morrow C, Halade GV. Obesogenic diet in aging mice disrupts gut microbe composition and alters neutrophil:lymphocyte ratio, leading to inflamed milieu in acute heart failure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(5) : 6456-6469, 2019. http://www.ncbi.nlm.nih.gov/pubmed/30768364
  • Goh KY, He L, Song J, Jinno M, Rogers AJ, Sethu P, Halade GV, Rajasekaran NS, Liu X, Prabhu SD, Darley-Usmar V, Wende AR, Zhou L. Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice. Redox biology. 21: 101100, 2019. http://www.ncbi.nlm.nih.gov/pubmed/30641298
  • Krishnan V, Booker D, Cunningham G, Jadapalli JK, Kain V, Pullen AB, Halade GV. Pretreatment of carprofen impaired initiation of inflammatory- and overlapping resolution response and promoted cardiorenal syndrome in heart failure. Life sciences. 218: 224-232, 2019. http://www.ncbi.nlm.nih.gov/pubmed/30597172
  • Kozlovskaya V, Liu F, Yang Y, Ingle K, Qian S, Halade GV, Urban VS, Kharlampieva E. Temperature-Responsive Polymersomes of Poly(3-methyl--vinylcaprolactam)--poly(-vinylpyrrolidone) To Decrease Doxorubicin-Induced Cardiotoxicity. Biomacromolecules. 20(10) : 3989-4000, 2019. http://www.ncbi.nlm.nih.gov/pubmed/31503464
  • Halade GV, Kain V, Wright GM, Jadapalli JK. Subacute treatment of carprofen facilitate splenocardiac resolution deficit in cardiac injury. Journal of leukocyte biology. 104(6) : 1173-1186, 2018. http://www.ncbi.nlm.nih.gov/pubmed/30145840
  • Rahman MM, El Jamali A, Halade GV, Ouhtit A, Abou-Saleh H, Pintus G. Nox2 Activity Is Required in Obesity-Mediated Alteration of Bone Remodeling. Oxidative medicine and cellular longevity. 2018: 6054361, 2018. http://www.ncbi.nlm.nih.gov/pubmed/30533174
  • Tourki B, Halade GV. The failing of the obesity paradox in the failing heart. American journal of physiology. Heart and circulatory physiology. , 2018. http://www.ncbi.nlm.nih.gov/pubmed/30074838
  • Kain V, Ingle KA, Kachman M, Baum H, Shanmugam G, Rajasekaran NS, Young ME, Halade GV. Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation. American journal of physiology. Heart and circulatory physiology. 314(2) : H160-H169, 2018. http://www.ncbi.nlm.nih.gov/pubmed/28986357
  • Halade GV, Kain V, Ingle KA. Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology. American journal of physiology. Heart and circulatory physiology. 314(2) : H255-H267, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29101178
  • Halade GV, Dorbane A, Ingle KA, Kain V, Schmitter JM, Rhourri-Frih B. Comprehensive targeted and non-targeted lipidomics analyses in failing and non-failing heart. Analytical and bioanalytical chemistry. 410(7) : 1965-1976, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29411084
  • Halade GV, Kain V, Serhan CN. Immune responsive resolvin D1 programs myocardial infarction-induced cardiorenal syndrome in heart failure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(7) : 3717-3729, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29455574
  • Halade GV, Norris PC, Kain V, Serhan CN, Ingle KA. Splenic leukocytes define the resolution of inflammation in heart failure. Science signaling. 11(520) , 2018. http://www.ncbi.nlm.nih.gov/pubmed/29511119
  • Jadapalli JK, Wright GW, Kain V, Sherwani MA, Sonkar R, Yusuf N, Halade GV. Doxorubicin triggers splenic contraction and irreversible dysregulation of COX and LOX that alters the inflammation-resolution program in the myocardium. American journal of physiology. Heart and circulatory physiology. 315(5) : H1091-H1100, 2018. http://www.ncbi.nlm.nih.gov/pubmed/30074834
  • DeLeon-Pennell KY, Iyer RP, Ma Y, Yabluchanskiy A, Zamilpa R, Chiao YA, Cannon PL, Kaplan A, Cates CA, Flynn ER, Halade GV, de Castro Brás LE, Lindsey ML. The Mouse Heart Attack Research Tool 1.0 database. American journal of physiology. Heart and circulatory physiology. 315(3) : H522-H530, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29775405
  • Jadapalli JK, Halade GV. Unified nexus of macrophages and maresins in cardiac reparative mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(10) : 5227-5237, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29750575
  • Kain V, Ingle KA, Kabarowski J, Barnes S, Limdi NA, Prabhu SD, Halade GV. Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction. Journal of molecular and cellular cardiology. 118: 70-80, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29526491
  • Halade GV, Kain V. Obesity and Cardiometabolic Defects in Heart Failure Pathology. Comprehensive Physiology. 7(4) : 1463-1477, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28915332
  • Kain V, Halade GV. Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy. Frontiers in cardiovascular medicine. 4: 31, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28620607
  • Tourki B, Halade G. Leukocyte diversity in resolving and nonresolving mechanisms of cardiac remodeling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(10) : 4226-4239, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28642328
  • Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED. Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses. American journal of physiology. Heart and circulatory physiology. 313(6) : H1098-H1108, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28822962
  • Kain V, Liu F, Kozlovskaya V, Ingle KA, Bolisetty S, Agarwal A, Khedkar S, Prabhu SD, Kharlampieva E, Halade GV. Resolution Agonist 15-epi-Lipoxin A Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing. Scientific reports. 7(1) : 9999, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28855632
  • Halade GV, Kain V, Ingle KA, Prabhu SD. Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healing. American journal of physiology. Heart and circulatory physiology. 313(1) : H89-H102, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28411230
  • Halade GV, Kain V, Black LM, Prabhu SD, Ingle KA. Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction. Aging. 8(11) : 2611-2634, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27777380
  • Yabluchanskiy A, Ma Y, DeLeon-Pennell KY, Altara R, Halade GV, Voorhees AP, Nguyen NT, Jin YF, Winniford MD, Hall ME, Han HC, Lindsey ML. Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. The journals of gerontology. Series A, Biological sciences and medical sciences. 71(4) : 475-83, 2016. http://www.ncbi.nlm.nih.gov/pubmed/25878031
  • DeLeon-Pennell KY, Tian Y, Zhang B, Cates CA, Iyer RP, Cannon P, Shah P, Aiyetan P, Halade GV, Ma Y, Flynn E, Zhang Z, Jin YF, Zhang H, Lindsey ML. CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac Remodeling. Circulation. Cardiovascular genetics. 9(1) : 14-25, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26578544
  • Kumar RR, Narasimhan M, Shanmugam G, Hong J, Devarajan A, Palaniappan S, Zhang J, Halade GV, Darley-Usmar VM, Hoidal JR, Rajasekaran NS. Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. Journal of translational medicine. 14: 86, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27048381
  • Halade GV, Ma Y. Neutrophils: Friend, foe, or contextual ally in myocardial healing. Journal of molecular and cellular cardiology. 97: 44-6, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27133770
  • Kain V, Halade GV. Big eater macrophages dominate inflammation resolution following myocardial infarction. Journal of molecular and cellular cardiology. 87: 225-7, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26342428
  • Voorhees AP, DeLeon-Pennell KY, Ma Y, Halade GV, Yabluchanskiy A, Iyer RP, Flynn E, Cates CA, Lindsey ML, Han HC. Building a better infarct: Modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction. Journal of molecular and cellular cardiology. 85: 229-39, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26080361
  • Ingle KA, Kain V, Goel M, Prabhu SD, Young ME, Halade GV. Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation. American journal of physiology. Heart and circulatory physiology. 309(11) : H1827-36, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26432841
  • Kain V, Ingle KA, Colas RA, Dalli J, Prabhu SD, Serhan CN, Joshi M, Halade GV. Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. Journal of molecular and cellular cardiology. 84: 24-35, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25870158
  • Souto Padron de Figueiredo A, Salmon AB, Bruno F, Jimenez F, Martinez HG, Halade GV, Ahuja SS, Clark RA, DeFronzo RA, Abboud HE, El Jamali A. Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet. The Journal of biological chemistry. 290(21) : 13427-39, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25825489
  • Lopez EF, Kabarowski JH, Ingle KA, Kain V, Barnes S, Crossman DK, Lindsey ML, Halade GV. Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction. American journal of physiology. Heart and circulatory physiology. 308(4) : H269-80, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25485899
  • Allison DB, Antoine LH, Ballinger SW, Bamman MM, Biga P, Darley-Usmar VM, Fisher G, Gohlke JM, Halade GV, Hartman JL, Hunter GR, Messina JL, Nagy TR, Plaisance EP, Powell ML, Roth KA, Sandel MW, Schwartz TS, Smith DL, Sweatt JD, Tollefsbol TO, Watts SA, Yang Y, Zhang J, Austad SN. Aging and energetics' 'Top 40' future research opportunities 2010-2013. F1000Research. 3: 219, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25324965
  • Kain V, Prabhu SD, Halade GV. Inflammation revisited: inflammation versus resolution of inflammation following myocardial infarction. Basic research in cardiology. 109(6) : 444, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25248433
  • Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey ML, Hanes M, Happel KI, Nelson S, Bagby GJ, Lorent JA, Cardinal P, Granados R, Esteban A, LeSaux CJ, Tuomanen EI, Orihuela CJ. Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS pathogens. 10(9) : e1004383, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25232870
  • Shivshankar P, Halade GV, Calhoun C, Escobar GP, Mehr AJ, Jimenez F, Martinez C, Bhatnagar H, Mjaatvedt CH, Lindsey ML, Le Saux CJ. Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction. Journal of molecular and cellular cardiology. 76: 84-93, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25128086
  • Tian Y, Koganti T, Yao Z, Cannon P, Shah P, Pietrovito L, Modesti A, Aiyetan P, DeLeon-Pennell K, Ma Y, Halade GV, Hicks C, Zhang H, Lindsey ML. Cardiac extracellular proteome profiling and membrane topology analysis using glycoproteomics. Proteomics. Clinical applications. 8(7-8) : 595-602, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24920555
  • de Castro Brás LE, Cates CA, DeLeon-Pennell KY, Ma Y, Iyer RP, Halade GV, Yabluchanskiy A, Fields GB, Weintraub ST, Lindsey ML. Citrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle. Antioxidants & redox signaling. 21(14) : 1974-85, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24382150
  • Halade GV, Ma Y, Ramirez TA, Zhang J, Dai Q, Hensler JG, Lopez EF, Ghasemi O, Jin YF, Lindsey ML. Reduced BDNF attenuates inflammation and angiogenesis to improve survival and cardiac function following myocardial infarction in mice. American journal of physiology. Heart and circulatory physiology. 305(12) : H1830-42, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24142413
  • Zamilpa R, Zhang J, Chiao YA, de Castro Brás LE, Halade GV, Ma Y, Hacker SO, Lindsey ML. Cardiac wound healing post-myocardial infarction: a novel method to target extracellular matrix remodeling in the left ventricle. Methods in molecular biology (Clifton, N.J.). 1037: 313-24, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24029944
  • Ma Y, Halade GV, Zhang J, Ramirez TA, Levin D, Voorhees A, Jin YF, Han HC, Manicone AM, Lindsey ML. Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation. Circulation research. 112(4) : 675-88, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23261783
  • Halade GV, Jin YF, Lindsey ML. Matrix metalloproteinase (MMP)-9: a proximal biomarker for cardiac remodeling and a distal biomarker for inflammation. Pharmacology & therapeutics. 139(1) : 32-40, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23562601
  • de Castro Brás LE, Ramirez TA, DeLeon-Pennell KY, Chiao YA, Ma Y, Dai Q, Halade GV, Hakala K, Weintraub ST, Lindsey ML. Texas 3-step decellularization protocol: looking at the cardiac extracellular matrix. Journal of proteomics. 86: 43-52, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23681174
  • Halade GV, Williams PJ, Veigas JM, Barnes JL, Fernandes G. Concentrated fish oil (Lovaza(R)) extends lifespan and attenuates kidney disease in lupus-prone short-lived (NZBxNZW)F1 mice. Experimental biology and medicine (Maywood, N.J.). 238(6) : 610-22, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23918873
  • Wang Y, Yang T, Ma Y, Halade GV, Zhang J, Lindsey ML, Jin YF. Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling post-myocardial infarction. BMC genomics. 13 Suppl 6: S21, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23134700
  • Ma Y, Halade GV, Lindsey ML. Extracellular matrix and fibroblast communication following myocardial infarction. Journal of cardiovascular translational research. 5(6) : 848-57, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22926488
  • Zamilpa R, Ibarra J, de Castro Brás LE, Ramirez TA, Nguyen N, Halade GV, Zhang J, Dai Q, Dayah T, Chiao YA, Lowell W, Ahuja SS, D'Armiento J, Jin YF, Lindsey ML. Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial infarction. Journal of molecular and cellular cardiology. 53(5) : 599-608, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22884843
  • Ma Y, Lindsey ML, Halade GV. DHA derivatives of fish oil as dietary supplements: a nutrition-based drug discovery approach for therapies to prevent metabolic cardiotoxicity. Expert opinion on drug discovery. 7(8) : 711-21, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22724444
  • Halade GV, Jin YF, Lindsey ML. Roles of saturated vs. polyunsaturated fat in heart failure survival: not all fats are created equal. Cardiovascular research. 93(1) : 4-5, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22068160
  • Rahman MM, Halade GV, Williams PJ, Fernandes G. t10c12-CLA maintains higher bone mineral density during aging by modulating osteoclastogenesis and bone marrow adiposity. Journal of cellular physiology. 226(9) : 2406-14, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21660964
  • Halade GV, Williams PJ, Lindsey ML, Fernandes G. Fish oil decreases inflammation and reduces cardiac remodeling in rosiglitazone treated aging mice. Pharmacological research. 63(4) : 300-7, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21193042
  • Halade GV, El Jamali A, Williams PJ, Fajardo RJ, Fernandes G. Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice. Experimental gerontology. 46(1) : 43-52, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20923699
  • Halade GV, Rahman MM, Williams PJ, Fernandes G. Combination of conjugated linoleic acid with fish oil prevents age-associated bone marrow adiposity in C57Bl/6J mice. The Journal of nutritional biochemistry. 22(5) : 459-69, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20656466
  • Halade GV, Rahman MM, Williams PJ, Fernandes G. High fat diet-induced animal model of age-associated obesity and osteoporosis. The Journal of nutritional biochemistry. 21(12) : 1162-9, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20149618
  • Halade GV, Rahman MM, Fernandes G. Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6J mice. The Journal of nutritional biochemistry. 21(4) : 332-7, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19423318
  • Halade GV, Rahman MM, Bhattacharya A, Barnes JL, Chandrasekar B, Fernandes G. Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus-prone mice. Journal of immunology (Baltimore, Md. : 1950). 184(9) : 5280-6, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20368275
  • Rahman M, Halade GV, El Jamali A, Fernandes G. Conjugated linoleic acid (CLA) prevents age-associated skeletal muscle loss. Biochemical and biophysical research communications. 383(4) : 513-8, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19393220
  • Halade GV, Rahman MM, Fernandes G. Effect of CLA isomers and their mixture on aging C57Bl/6J mice. European journal of nutrition. 48(7) : 409-18, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19424653