David Russ, PhD

Associate Professor, School of Physical Therapy & Rehabilitation Sciences

Academic Email: druss2@usf.edu

View My C.V.

Education

Research Interests

• Research Focus: Skeletal muscle physiology with an emphasis on healthy aging and muscle fatigue in clinical populations, ranging from HIV to low-back pain. In the Integrative and Applied Muscle Biology (IAMB) Laboratory, I use methods ranging from function testing to molecular biology to evaluate muscle function at the level of the organism, organ, tissue, cell and molecular levels in human an animal models. A recently-completed study, funded by the NIH, examined the use of Trimetazidine-HCl as a possible intervention for the enhancement of aging muscle performance. Additional areas of interest include central and peripheral aspects of fatigue, nutritional interventions to improve health and the clinical use of neuromuscular electrical stimulation.

Memberships

• Member (American College of Sports Medicine, 2008 - Present)
• Member (American Physiological Society, 1999 - Present)
• Member (American Physical Therapy Association, 1993 - Present)

Recent Publications

• Slayton M, Balakrishnan B, Gupta A, Jobe S, Puri I, Neely S, Tamori Y, Russ DW, Yildirim G, Yakar S, Sharma VM, Puri V. Fsp27 plays a crucial role in muscle performance. American journal of physiology. Endocrinology and metabolism. 322(4) : E331-E343, 2022.
• Russ DW, Wages NP, Clark LA, Suhr JA, Clark BC. Discrepancies in hand motor performance and executive function in older adults. Aging clinical and experimental research. 34(9) : 2225-2229, 2022.
• Manickam R, Tur J, Badole SL, Chapalamadugu KC, Sinha P, Wang Z, Russ DW, Brotto M, Tipparaju SM. Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators. Journal of cachexia, sarcopenia and muscle. 13(2) : 1177-1196, 2022.
• Moskowitz S, Russ DW, Clark LA, Wages NP, Grooms DR, Woods AJ, Suhr J, Simon JE, O''Shea A, Criss CR, Fadda P, Clark BC. Is impaired dopaminergic function associated with mobility capacity in older adults? GeroScience. 43(3) : 1383-1404, 2021.
• Russ DW, Amano S, Law TD, Thomas JS, Clark BC. Multiple measures of muscle function influence Sorensen Test performance in individuals with recurrent low back pain. Journal of back and musculoskeletal rehabilitation. 34(1) : 139-147, 2021.
• Stamenkovic A, Clark BC, Pidcoe PE, van der Veen SM, France CR, Russ DW, Kinser PA, Thomas JS. Distinguishing chronic low back pain in young adults with mild to moderate pain and disability using trunk compliance. Scientific reports. 11(1) : 7592, 2021.
• Clark LA, Manini TM, Wages NP, Simon JE, Russ DW, Clark BC. Reduced Neural Excitability and Activation Contribute to Clinically Meaningful Weakness in Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences. 76(4) : 692-702, 2021.
• Tavoian D, Russ DW, Law TD, Simon JE, Chase PJ, Guseman EH, Clark BC. Effects of Three Different Exercise Strategies for Optimizing Aerobic Capacity and Skeletal Muscle Performance in Older Adults: A Pilot Study. The Journal of frailty & aging. 10(4) : 357-360, 2021.
• Clark LA, Russ DW, Tavoian D, Arnold WD, Law TD, France CR, Clark BC. Heterogeneity of the strength response to progressive resistance exercise training in older adults: Contributions of muscle contractility. Experimental gerontology. 152: 111437, 2021.
• Russ DW, Dimova K, Morris E, Pacheco M, Garvey SM, Scordilis SP. Dietary fish oil supplement induces age-specific contractile and proteomic responses in muscles of male rats. Lipids in health and disease. 19(1) : 165, 2020.
• Tavoian D, Russ DW, Consitt LA, Clark BC. Perspective: Pragmatic Exercise Recommendations for Older Adults: The Case for Emphasizing Resistance Training. Frontiers in physiology. 11: 799, 2020.
• Thomas JS, Clark BC, Russ DW, France CR, Ploutz-Snyder R, Corcos DM. Effect of Spinal Manipulative and Mobilization Therapies in Young Adults With Mild to Moderate Chronic Low Back Pain: A Randomized Clinical Trial. JAMA network open. 3(8) : e2012589, 2020.
• Riwniak C, Simon JE, Wages NP, Clark LA, Manini TM, Russ DW, Clark BC. Comparison of a Multi-Component Physical Function Battery to Usual Walking Speed for Assessing Lower Extremity Function and Mobility Limitation in Older Adults. The journal of nutrition, health & aging. 24(8) : 906-913, 2020.
• Wages NP, Simon JE, Clark LA, Amano S, Russ DW, Manini TM, Clark BC. Relative contribution of muscle strength, lean mass, and lower extremity motor function in explaining between-person variance in mobility in older adults. BMC geriatrics. 20(1) : 255, 2020.
• Varadhan R, Russ DW, Gabr RE, Huang J, Kalyani RR, Xue QL, Cappola AR, Bandeen-Roche K, Fried LP. Relationship of Physical Frailty to Phosphocreatine Recovery in Muscle after Mild Exercise Stress in the Oldest-Old Women. The Journal of frailty & aging. 8(4) : 162-168, 2019.
• Ampomah K, Amano S, Wages NP, Volz L, Clift R, Ludin AFM, Nakazawa M, Law TD, Manini TM, Thomas JS, Russ DW, Clark BC. Blood Flow-restricted Exercise Does Not Induce a Cross-Transfer of Effect: A Randomized Controlled Trial. Medicine and science in sports and exercise. 51(9) : 1817-1827, 2019.
• Applegate ME, France CR, Russ DW, Leitkam ST, Thomas JS. Sørensen test performance is driven by different physiological and psychological variables in participants with and without recurrent low back pain. Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology. 44: 1-7, 2019.
• Applegate ME, France CR, Russ DW, Leitkam ST, Thomas JS. Determining Physiological and Psychological Predictors of Time to Task Failure on a Virtual Reality Sørensen Test in Participants With and Without Recurrent Low Back Pain: Exploratory Study. JMIR serious games. 6(3) : e10522, 2018.
• Russ DW, Garvey SM, Densmore C, Hawks T, Herman S, Pardi K. Effect of acute muscle contusion injury, with and without dietary fish oil, on adult and aged male rats: contractile and biochemical responses. Experimental gerontology. 111: 241-252, 2018.
• Russ DW, Ross AJ, Clark BC, Thomas JS. The Effects of Task Type on Time to Task Failure During Fatigue: A Modified Sørensen Test. Journal of motor behavior. 50(1) : 96-103, 2018.
• Russ DW, Acksel C, McCorkle KW, Edens NK, Garvey SM. Effects of Running Wheel Activity and Dietary HMB and β-alanine Co-Supplementation on Muscle Quality in Aged Male Rats. The journal of nutrition, health & aging. 21(5) : 554-561, 2017.
• Oki K, Mahato NK, Nakazawa M, Amano S, France CR, Russ DW, Clark BC. Preliminary Evidence That Excitatory Transcranial Direct Current Stimulation Extends Time to Task Failure of a Sustained, Submaximal Muscular Contraction in Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences. 71(8) : 1109-12, 2016.
• Russ DW, Boyd IM, McCoy KM, McCorkle KW. Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism. Biogerontology. 16(6) : 747-59, 2015.
• Russ DW, Acksel C, Boyd IM, Maynard J, McCorkle KW, Edens NK, Garvey SM. Dietary HMB and β-alanine co-supplementation does not improve in situ muscle function in sedentary, aged male rats. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 40(12) : 1294-301, 2015.
• Clark BC, Taylor JL, Hong SL, Law TD, Russ DW. Weaker Seniors Exhibit Motor Cortex Hypoexcitability and Impairments in Voluntary Activation. The journals of gerontology. Series A, Biological sciences and medical sciences. 70(9) : 1112-9, 2015.
• Russ DW, Nakazawa M, Boyd IM. A Pilot Study of Age-Related Changes in the Sphingolipid Composition of the Rat Sarcoplasmic Reticulum. The Journal of frailty & aging. 4(4) : 166-72, 2015.
• Garvey SM, Russ DW, Skelding MB, Dugle JE, Edens NK. Molecular and metabolomic effects of voluntary running wheel activity on skeletal muscle in late middle-aged rats. Physiological reports. 3(2) , 2015.
• Russ DW, Wills AM, Boyd IM, Krause J. Weakness, SR function and stress in gastrocnemius muscles of aged male rats. Experimental gerontology. 50: 40-4, 2014.
• Romani WA, Russ DW. Acute effects of sex-specific sex hormones on heat shock proteins in fast muscle of male and female rats. European journal of applied physiology. 113(10) : 2503-10, 2013.
• Russ DW, Gregg-Cornell K, Conaway MJ, Clark BC. Evolving concepts on the age-related changes in "muscle quality". Journal of cachexia, sarcopenia and muscle. 3(2) : 95-109, 2012.
• Russ DW, Krause J, Wills A, Arreguin R. "SR stress" in mixed hindlimb muscles of aging male rats. Biogerontology. 13(5) : 547-55, 2012.
• Russ DW, Clark BC, Krause J, Hagerman FC. Development of a neuromuscular electrical stimulation protocol for sprint training. Medicine and science in sports and exercise. 44(9) : 1810-9, 2012.
• Tennant KF, Takacs SE, Gau JT, Clark BC, Russ DW. A preliminary study of symptomatic fatigue in rural older adults. Aging clinical and experimental research. 24(4) : 324-30, 2012.
• Horner AM, Russ DW, Biknevicius AR. Effects of early-stage aging on locomotor dynamics and hindlimb muscle force production in the rat. The Journal of experimental biology. 214(Pt 21) : 3588-95, 2011.
• Russ DW, Grandy JS. Increased desmin expression in hindlimb muscles of aging rats. Journal of cachexia, sarcopenia and muscle. 2(3) : 175-180, 2011.
• Thomas JS, Ross AJ, Russ DW, Clark BC. Time to task failure of trunk extensor muscles differs with load type. Journal of motor behavior. 43(1) : 27-9, 2011.
• Russ DW, Grandy JS, Toma K, Ward CW. Ageing, but not yet senescent, rats exhibit reduced muscle quality and sarcoplasmic reticulum function. Acta physiologica (Oxford, England). 201(3) : 391-403, 2011.
• McGinley M, Hoffman RL, Russ DW, Thomas JS, Clark BC. Older adults exhibit more intracortical inhibition and less intracortical facilitation than young adults. Experimental gerontology. 45(9) : 671-8, 2010.
• Dearth DJ, Umbel J, Hoffman RL, Russ DW, Wilson TE, Clark BC. Men and women exhibit a similar time to task failure for a sustained, submaximal elbow extensor contraction. European journal of applied physiology. 108(6) : 1089-98, 2010.
• Oursler KK, Katzel LI, Smith BA, Scott WB, Russ DW, Sorkin JD. Prediction of cardiorespiratory fitness in older men infected with the human immunodeficiency virus: clinical factors and value of the six-minute walk distance. Journal of the American Geriatrics Society. 57(11) : 2055-61, 2009.
• Clark BC, Manini TM, Hoffman RL, Russ DW. Restoration of voluntary muscle strength after 3 weeks of cast immobilization is suppressed in women compared with men. Archives of physical medicine and rehabilitation. 90(1) : 178-80, 2009.
• Lovering RM, Russ DW. Fiber type composition of cadaveric human rotator cuff muscles. The Journal of orthopaedic and sports physical therapy. 38(11) : 674-80, 2008.
• Russ DW, Towse TF, Wigmore DM, Lanza IR, Kent-Braun JA. Contrasting influences of age and sex on muscle fatigue. Medicine and science in sports and exercise. 40(2) : 234-41, 2008.
• Russ DW. Active and passive tension interact to promote Akt signaling with muscle contraction. Medicine and science in sports and exercise. 40(1) : 88-95, 2008.
• Scott WB, Oursler KK, Katzel LI, Ryan AS, Russ DW. Central activation, muscle performance, and physical function in men infected with human immunodeficiency virus. Muscle & nerve. 36(3) : 374-83, 2007.
• Russ DW, Lovering RM. Influence of activation frequency on cellular signalling pathways during fatiguing contractions in rat skeletal muscle. Experimental physiology. 91(6) : 957-66, 2006.
• Russ DW, Lanza IR, Rothman D, Kent-Braun JA. Sex differences in glycolysis during brief, intense isometric contractions. Muscle & nerve. 32(5) : 647-55, 2005.
• Lanza IR, Russ DW, Kent-Braun JA. Age-related enhancement of fatigue resistance is evident in men during both isometric and dynamic tasks. Journal of applied physiology (Bethesda, Md. : 1985). 97(3) : 967-75, 2004.
• Russ DW, Kent-Braun JA. Sex differences in human skeletal muscle fatigue are eliminated under ischemic conditions. Journal of applied physiology (Bethesda, Md. : 1985). 94(6) : 2414-22, 2003.
• Russ DW, Elliott MA, Vandenborne K, Walter GA, Binder-Macleod SA. Metabolic costs of isometric force generation and maintenance of human skeletal muscle. American journal of physiology. Endocrinology and metabolism. 282(2) : E448-57, 2002.