Srinivas Nagaraj Bharadwaj I-4947-2012

Srinivas Nagaraj Bharadwaj, PHD

Assistant Professor, Internal Medicine, Morsani College of Medicine

Assistant Professor, Molecular Medicine, Morsani College of Medicine

Member, H. Lee Moffitt Cancer Center & Research Institute

Assistant Professor, Division of Pharmaceutical Sciences, College of Pharmacy

Assistant Professor, Physical Therapy & Rehabilitation Sciences

Contact Info Division of Translational Medicine
12901 Bruce B. Downs Blvd., MDC 19
Tampa FL 33612

Academic Email: snagaraj@health.usf.edu

Academic Phone:(813) 974-4585

View My C.V.

Education

  • -, Training - Tumor Immunology/Immmunotherapy, H Lee Moffitt Cancer Center, 2007
  • -, Training- Tumor Immunology/Immunotherapy, University Clinic Bonn, 2004
  • PhD, Anatomy, Bangalore University, 2001
  • M.S, Human Anatomy, Kasturba Medical College, 1995
  • B.S, Microbiology, St.Josephs College, 1992

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Biomedical Engineering & Nanomedicine
  • Cancer Biology

Memberships

  • American Association for Advancement of Science (., 2014 - Present)
  • American Association of Immunologists (Full member, 2006 - Present)
  • American Association of Cancer Research (Full member, 2005 - Present)

Recent Publications

  • Subhra Mohapatra, Srinivas Nagaraj, Shyam S Mohapatra. Nano/bio interface:impact on drug delivery applications Drug Delivery and Translational Research. 3(4) : 295-296, 2013.
  • Srinivas Nagaraj, Allison Nelson, Subhra Mohapatra, Shyam Mohapatra. Role of NPRA in MDSC mediated suppression in cancer (meeting abstract) Journal of Immunology. 190: 53.36, 2013.
  • Mallela J, Ravi S, Jean Louis F, Mulaney B, Cheung M, Sree Garapati U, Chinnasamy V, Wang C, Nagaraj S, Mohapatra SS, Mohapatra S. Natriuretic peptide receptor A signaling regulates stem cell recruitment and angiogenesis: a model to study linkage between inflammation and tumorigenesis. Stem cells (Dayton, Ohio). 31(7) : 1321-9, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23533187
  • Wang D, Yu Y, Haarberg K, Fu J, Kaosaard K, Nagaraj S, Anasetti C, Gabrilovich D, Yu XZ. Dynamic change and impact of myeloid-derived suppressor cells in allogeneic bone marrow transplantation in mice. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19(5) : 692-702, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23376089
  • Nagaraj S, Youn JI, Gabrilovich DI. Reciprocal relationship between myeloid-derived suppressor cells and T cells. Journal of immunology (Baltimore, Md. : 1950). 191(1) : 17-23, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23794702
  • Nelson A, Nair S, Nagaraj S. CD4(+) T cells suppress immune response to cancer: novel targets for antitumor efforts. Expert review of clinical immunology. 8(5) : 401-3, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22882213
  • Nagaraj S, Nelson A, Youn JI, Cheng P, Quiceno D, Gabrilovich DI. Antigen-specific CD4(+) T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling. Cancer research. 72(4) : 928-38, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22237629
  • Brar T, Nagaraj S, Mohapatra S. Microbes and asthma: the missing cellular and molecular links. Current opinion in pulmonary medicine. 18(1) : 14-22, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22113000
  • Nagaraj S, Gabrilovich DI. Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells. Seminars in cancer biology. 22(4) : 282-8, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22313876
  • Herber DL, Cao W, Nefedova Y, Novitskiy SV, Nagaraj S, Tyurin VA, Corzo A, Cho HI, Celis E, Lennox B, Knight SC, Padhya T, McCaffrey TV, McCaffrey JC, Antonia S, Fishman M, Ferris RL, Kagan VE, Gabrilovich DI. Lipid accumulation and dendritic cell dysfunction in cancer. Nature medicine. 16(8) : 880-6, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20622859
  • Ramakrishnan R, Assudani D, Nagaraj S, Hunter T, Cho HI, Antonia S, Altiok S, Celis E, Gabrilovich DI. Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice. The Journal of clinical investigation. 120(4) : 1111-24, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20234093
  • Nagaraj S, Youn JI, Weber H, Iclozan C, Lu L, Cotter MJ, Meyer C, Becerra CR, Fishman M, Antonia S, Sporn MB, Liby KT, Rawal B, Lee JH, Gabrilovich DI. Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 16(6) : 1812-23, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20215551
  • Nagaraj S, Schrum AG, Cho HI, Celis E, Gabrilovich DI. Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. Journal of immunology (Baltimore, Md. : 1950). 184(6) : 3106-16, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20142361
  • Nagaraj S, Gabrilovich DI. Myeloid-derived suppressor cells in human cancer. Cancer journal (Sudbury, Mass.). 16(4) : 348-53, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20693846
  • Nagaraj S, Collazo M, Corzo CA, Youn JI, Ortiz M, Quiceno D, Gabrilovich DI. Regulatory myeloid suppressor cells in health and disease. Cancer research. 69(19) : 7503-6, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19752086
  • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nature reviews. Immunology. 9(3) : 162-74, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19197294
  • Youn JI, Nagaraj S, Collazo M, Gabrilovich DI. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. Journal of immunology (Baltimore, Md. : 1950). 181(8) : 5791-802, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18832739
  • Ziske C, Tiemann K, Schmidt T, Nagaraj S, Märten A, Schmitz V, Clarenbach R, Sauerbruch T, Schmidt-Wolf IG. Real-time high-resolution compound imaging allows percutaneous initiation and surveillance in an orthotopic murine pancreatic cancer model. Pancreas. 36(2) : 146-52, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18376305
  • Nagaraj S, Gabrilovich DI. Tumor escape mechanism governed by myeloid-derived suppressor cells. Cancer research. 68(8) : 2561-3, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18413722
  • Cheng P, Corzo CA, Luetteke N, Yu B, Nagaraj S, Bui MM, Ortiz M, Nacken W, Sorg C, Vogl T, Roth J, Gabrilovich DI. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. The Journal of experimental medicine. 205(10) : 2235-49, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18809714
  • Nagaraj S, Neumann J, Winzen B, Frank S, Ziske C, Sievers E, Koch N, Schmidt-Wolf IG. Pancreas carcinoma antigen fused to invariant chain elicits T-cell response and tumor growth inhibition. Pancreas. 37(3) : 321-7, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18815556
  • Herber DL, Nagaraj S, Djeu JY, Gabrilovich DI. Mechanism and therapeutic reversal of immune suppression in cancer. Cancer research. 67(11) : 5067-9, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17545581
  • Nagaraj S, Gupta K, Pisarev V, Kinarsky L, Sherman S, Kang L, Herber DL, Schneck J, Gabrilovich DI. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nature medicine. 13(7) : 828-35, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17603493
  • Nagaraj S, Pisarev V, Kinarsky L, Sherman S, Muro-Cacho C, Altieri DC, Gabrilovich DI. Dendritic cell-based full-length survivin vaccine in treatment of experimental tumors. Journal of immunotherapy (Hagerstown, Md. : 1997). 30(2) : 169-79, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17471164
  • Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. The Journal of experimental medicine. 204(6) : 1463-74, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17548519
  • Kusmartsev S, Nagaraj S, Gabrilovich DI. Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells. Journal of immunology (Baltimore, Md. : 1950). 175(7) : 4583-92, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16177103
  • Nefedova Y, Nagaraj S, Rosenbauer A, Muro-Cacho C, Sebti SM, Gabrilovich DI. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer research. 65(20) : 9525-35, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16230418
  • Nagaraj S, Ziske C, Schmidt-Wolf IG. Human cytokine-induced killer cells have enhanced in vitro cytolytic activity via non-viral interleukin-2 gene transfer. Genetic vaccines and therapy. 2(1) : 12, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15329148
  • Ziske C, Nagaraj S, Märten A, Gorschlüter M, Strehl J, Sauerbruch T, Abraham NG, Schmidt-Wolf IG. Retroviral IFN-alpha gene transfer combined with gemcitabine acts synergistically via cell cycle alteration in human pancreatic carcinoma cells implanted orthotopically in nude mice. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 24(8) : 490-6, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15320962
  • Gross C, Schmidt-Wolf IG, Nagaraj S, Gastpar R, Ellwart J, Kunz-Schughart LA, Multhoff G. Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cells. Cell stress & chaperones. 8(4) : 348-60, 2003. http://www.ncbi.nlm.nih.gov/pubmed/15115287

Positions Held

  • Research Assistant Professor- Immunology (H. Lee Moffitt Cancer Center & Research Institute, . 2007 - 2009)
  • Postdoctoral Fellow -Tumor Immunology (H. Lee Moffitt Cancer Center & Research Institute, . 2004 - 2007)
  • Scientist - Immune Therapy (Immune and Gene Therapy Lab, Internal Medicine, Uni-Clinic 2001 - 2004)
  • Lecturer (Anatomy, St. John's Medical College 1995 - 2001)

Awards/Honors

  • Junior faculty award (American Association of Immunologists - 2012)
  • Scholarship (Keystone Symposia - 2010)