USF Heart Institute

Mack Wu

Mack Wu, MD

Professor, College of Medicine Molecular Medicine

Professor, College of Medicine Surgery

Contact Info

Academic Email:


  • M.D., Medicine, Second Military Medical University, 1984

Recent Publications

  • Haines RJ, Beard RS, Chen L, Eitnier RA, Wu MH. Interleukin-1β Mediates β-Catenin-Driven Downregulation of Claudin-3 and Barrier Dysfunction in Caco2 Cells. Digestive Diseases and Sciences. 61(8) : 2252-61, 2016.
  • Haines RJ, Beard RS, Eitner RA, Chen L, Wu MH. TNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial Cells. PloS ONE. 11(4) : e0154351, 2016.
  • Breslin JW, Daines DA, Doggett TM, Kurtz KH, Souza-Smith FM, Zhang XE, Wu MH, Yuan SY. Rnd3 as a Novel Target to Ameliorate Microvascular Leakage. Journal of the American Heart Association. 5(4) : e003336, 2016.
  • Haines RJ, Beard RS, Wu MH. Protein tyrosine kinase 6 mediates TNFα-induced endothelial barrier dysfunction. Biochemical and Biophysical Research Communications. 456(1) : 190-6, 2015.
  • Trujillo AN Kesl SL Sherwood J Wu MH and Gould LJ. Demonstration of the Rat Ischemic Skin Wound Model. Journal of Visualized Experiments. 1(98) : e52637, 2015.
  • Chatterjee V, Beard RS, Reynolds JJ, Haines R, Guo M, Rubin M, Guido J, Wu MH, Yuan SY. MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression. PloS ONE. 9(10) : e110286, 2014.
  • Beard RS Jr1 Haines RJ Wu KY Reynolds JJ Davis SM Elliott JE Malinin NL Chatterjee V Cha BJ Wu MH Yuan SY. Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells. J Cell Sci.. 127(8) : 1840-53, 2014.
  • Fujita M1 Ieguchi K Cedano-Prieto DM Fong A Wilkerson C Chen JQ Wu M Lo SH Cheung AT Wilson MD Cardiff RD Borowsky AD Takada YK Takada Y. An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R. J Biol Chem.. 288(27) : 19593-603, 2013.
  • Rigor RR Shen Q Pivetti CD Wu MH Yuan S. Myosin light chain kinase signaling in endothelial barrier dysfunction. Med Res Rev.. 33(5) : 911-33, 2013.
  • Sun C, Beard RS, McLean DL, Rigor RR, Konia T, Wu MH, Yuan SY. ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304(3) : L135-42, 2013.
  • Guo M, Yuan SY, Frederich BJ, Sun C, Shen Q, McLean DL, Wu MH. Role of non-muscle myosin light chain kinase in neutrophil-mediated intestinal barrier dysfunction during thermal injury. Shock (Augusta, Ga.). 38(4) : 436-43, 2012.
  • Sun C, Wu MH, Lee ES, Yuan SY. A disintegrin and metalloproteinase 15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity. Arteriosclerosis, Thrombosis, and Vascular Biology. 32(10) : 2444-51, 2012.
  • Yuan SY, Shen Q, Rigor RR, Wu MH. Neutrophil transmigration, focal adhesion kinase and endothelial barrier function. Microvascular Research. 83(1) : 82-8, 2012.
  • Lee ES, Van Spyk EN, Chun KC, Pitts RL, Wu MH, Yuan SY. Monocytic adhesion molecule expression and monocyte-endothelial cell dysfunction are increased in patients with peripheral vascular disease versus patients with abdominal aortic aneurysms. The Journal of Surgical Research. 177(2) : 373-81, 2012.
  • Sun C Wu MH and Yuan SY. nmMLCK deficiency ameliorates atherosclerosis in ApoE-deficient mice via reduced endothelial barrier dysfunction and monocyte migration. Circulation. 124: 48-57, 2011.
  • Lee ES, Shen Q, Pitts RL, Guo M, Wu MH, Sun SC, Yuan SY. Serum metalloproteinases MMP-2, MMP-9, and metalloproteinase tissue inhibitors in patients are associated with arteriovenous fistula maturation. Journal of Vascular Surgery. 54(2) : 454-9; discussion 459-60, 2011.
  • Shen Q, Lee ES, Pitts RL, Wu MH, Yuan SY. Tissue inhibitor of metalloproteinase-2 regulates matrix metalloproteinase-2-mediated endothelial barrier dysfunction and breast cancer cell transmigration through lung microvascular endothelial cells. Molecular Cancer Research : MCR. 8(7) : 939-51, 2010.
  • Shen Q, Rigor RR, Pivetti CD, Wu MH, Yuan SY. Myosin light chain kinase in microvascular endothelial barrier function. Cardiovascular Research. 87(2) : 272-80, 2010.
  • Lee ES Shen Q Pitts RL Guo M Wu MH and Yuan SY. Vein graft expression of matrix metalloproteinase as biomarker for hemodialysis arteriovenous fistula maturation. Vas Endovas Surg. 44: 674-79, 2010.
  • Sun C Wu MH Guo M Day ML Lee ES and Yuan SY. ADAM 15 regulates endothelial permeability and neutrophil migration viaSrc/ERK1/2 signaling. Cardiovasc Res. 15(87) : 348-55, 2010.
  • Shen Q Wu MH and Yuan SY. Endothelial contractile cytoskeleton and microvascular permeability. Cell Health and Cytoskeleton. 1: 43-50, 2009.