Eye Institute

Quick Links

* (MCOM Eye Institute FP)

Peter Pavan

Peter Pavan

Contact Info

Education

  • MD, Medicine, Harvard University, 1972

Research Interests

  • Research interests (studies) include:
  • Age-Related Macular Degeneration (VIEW-1)(Re-VIEW)
  • Diabetic Macular Edema (RISE)
  • Ocular Complications of AIDS (LSOCA)
  • Uveitis (MUST)
  • Retinal Vein Occlusion (RVO (VIBRANT)
  • Geographic Atrophy (BAM)

Recent Publications

  • Goldstein BG, Pavan PR. ''Blow-outs'' in the retinal pigment epithelium. The British journal of ophthalmology. 71(9) : 676-81, 1987.
  • Lopez M, Johnson JG, Margo CE, Pavan PR. CAVERNOUS HEMANGIOMALIKE CHANGES IN A CHOROIDAL MELANOMA AFTER BRACHYTHERAPY. Retinal cases & brief reports. 10(1) : 15-7, 2016.
  • Simpson CL, Wojciechowski R, Oexle K, Murgia F, Portas L, Li X, Verhoeven VJ, Vitart V, Schache M, Hosseini SM, Hysi PG, Raffel LJ, Cotch MF, Chew E, Klein BE, Klein R, Wong TY, van Duijn CM, Mitchell P, Saw SM, Fossarello M, Wang JJ, Polašek O, Campbell H, Rudan I, Oostra BA, Uitterlinden AG, Hofman A, Rivadeneira F, Amin N, Karssen LC, Vingerling JR, Döring A, Bettecken T, Bencic G, Gieger C, Wichmann HE, Wilson JF, Venturini C, Fleck B, Cumberland PM, Rahi JS, Hammond CJ, Hayward C, Wright AF, Paterson AD, Baird PN, Klaver CC, Rotter JI, Pirastu M, Meitinger T, Bailey-Wilson JE, Stambolian D. Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. PloS one. 9(9) : e107110, 2014.
  • Boyer DS, Yoon YH, Belfort R, Bandello F, Maturi RK, Augustin AJ, Li XY, Cui H, Hashad Y, Whitcup SM. Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology. 121(10) : 1904-14, 2014.
  • Sugar EA, Holbrook JT, Kempen JH, Burke AE, Drye LT, Thorne JE, Louis TA, Jabs DA, Altaweel MM, Frick KD. Cost-effectiveness of fluocinolone acetonide implant versus systemic therapy for noninfectious intermediate, posterior, and panuveitis. Ophthalmology. 121(10) : 1855-62, 2014.
  • Kozak I1, Vaidya V2, Van Natta ML2, Pak JW3, May KP2, Thorne JE4; Studies of the Ocular Complications of AIDS Research Group. The prevalence and incidence of epiretinal membranes in eyes with inactive extramacular CMV retinitis. Invest Ophthalmol Vis Sci.. 55: 4304-12, 2014.
  • Friedman DS, Holbrook JT, Ansari H, Alexander J, Burke A, Reed SB, Katz J, Thorne JE, Lightman SL, Kempen JH. Risk of elevated intraocular pressure and glaucoma in patients with uveitis: results of the multicenter uveitis steroid treatment trial. Ophthalmology. 120(8) : 1571-9, 2013.
  • Kempen JH, Sugar EA, Jaffe GJ, Acharya NR, Dunn JP, Elner SG, Lightman SL, Thorne JE, Vitale AT, Altaweel MM. Fluorescein angiography versus optical coherence tomography for diagnosis of uveitic macular edema. Ophthalmology. 120(9) : 1852-9, 2013.
  • Orchard TJ, Lyons TJ, Cleary PA, Braffett BH, Maynard J, Cowie C, Gubitosi-Klug RA, Way J, Anderson K, Barnie A, Villavicencio S. The association of skin intrinsic fluorescence with type 1 diabetes complications in the DCCT/EDIC study. Diabetes care. 36(10) : 3146-53, 2013.
  • Jacobson AM, Braffett BH, Cleary PA, Gubitosi-Klug RA, Larkin ME. The long-term effects of type 1 diabetes treatment and complications on health-related quality of life: a 23-year follow-up of the Diabetes Control and Complications/Epidemiology of Diabetes Interventions and Complications cohort. Diabetes care. 36(10) : 3131-8, 2013.
  • Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Mishra A, Wang YX, Wang JJ, Rochtchina E, Polasek O, Wright AF, Amin N, van Leeuwen EM, Wilson JF, Pennell CE, van Duijn CM, de Jong PT, Vingerling JR, Zhou X, Chen P, Li R, Tay WT, Zheng Y, Chew M, Burdon KP, Craig JE, Iyengar SK, Igo RP, Lass JH, Chew EY, Haller T, Mihailov E, Metspalu A, Wedenoja J, Simpson CL, Wojciechowski R, Höhn R, Mirshahi A, Zeller T, Pfeiffer N, Lackner KJ, Bettecken T, Meitinger T, Oexle K, Pirastu M, Portas L, Nag A, Williams KM, Yonova-Doing E, Klein R, Klein BE, Hosseini SM, Paterson AD, Makela KM, Lehtimaki T, Kahonen M, Raitakari O, Yoshimura N, Matsuda F, Chen LJ, Pang CP, Yip SP, Yap MK, Meguro A, Mizuki N, Inoko H, Foster PJ, Zhao JH, Vithana E, Tai ES, Fan Q, Xu L, Campbell H, Fleck B, Rudan I, Aung T, Hofman A, Uitterlinden AG, Bencic G, Khor CC, Forward H, Pärssinen O, Mitchell P, Rivadeneira F, Hewitt AW, Williams C, Oostra BA, Teo YY, Hammond CJ, Stambolian D, Mackey DA, Klaver CC, Wong TY, Saw SM, Baird PN. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. American journal of human genetics. 93(2) : 264-77, 2013.
  • Nathan DM, Bayless M, Cleary P, Genuth S, Gubitosi-Klug R, Lachin JM, Lorenzi G, Zinman B. Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions. Diabetes. 62(12) : 3976-86, 2013.
  • Jabs DA, Ahuja A, Van Natta M, Dunn JP, Yeh S. Comparison of treatment regimens for cytomegalovirus retinitis in patients with AIDS in the era of highly active antiretroviral therapy. Ophthalmology. 120(6) : 1262-70, 2013.
  • Gapsis BC, Ranjit RU, Malavade S, Carey A, Murtagh R, Drucker MD, Pavan PR. Spontaneous resolution of ophthalmologic symptoms following bilateral traumatic carotid cavernous fistulae. Digital journal of ophthalmology : DJO / sponsored by Massachusetts Eye and Ear Infirmary. 19(2) : 33-8, 2013.
  • Walia HS, Shah SD, Walia SS, Pavan PR, Margo CE. Rapidly enlarging choroidal melanoma: perioperative treatment implications. Retinal cases & brief reports. 7(1) : 75-7, 2013.
  • Malavade S, S, Mai M, Pavan P, Nasr G, Sandin R, & Greene J. Endogenous Fusarium Endophthalmitis in Hematologic Malignancy: Short Case Series and Review of Literature. Infectious Diseases in Clinical Practice. , 2012.
  • Sen HN, Drye LT, Goldstein DA, Larson TA, Merrill PT, Pavan PR, Sheppard JD, Burke A, Srivastava SK, Jabs DA. Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial. Ocular immunology and inflammation. 20(2) : 104-12, 2012.
  • Sugar EA, Jabs DA, Ahuja A, Thorne JE, Danis RP, Meinert CL. Incidence of cytomegalovirus retinitis in the era of highly active antiretroviral therapy. American journal of ophthalmology. 153(6) : 1016-24.e5, 2012.
  • Frick KD, Drye LT, Kempen JH, Dunn JP, Holland GN, Latkany P, Rao NA, Sen HN, Sugar EA, Thorne JE, Wang RC, Holbrook JT. Associations among visual acuity and vision- and health-related quality of life among patients in the multicenter uveitis steroid treatment trial. Investigative ophthalmology & visual science. 53(3) : 1169-76, 2012.
  • Kalyani PS Holland GN Fawzi AA Arantes TEF Sadun AA; in collaboration with the Studies of Ocular Complication of AIDS Research Group. Association between retinal nerve fiber layer thickness and abnormalities of vision in people with human immunodeficiency virus infection. Am J Ophthalmol. 153(4) : 734-742, 2012.
  • Kalyani PS Fawzi AA Gangaputra S Van Natta ML Hubbard LD Danis RP Thorne JE Holland GN; on behalf of the Studies of Ocular Complications of AIDS Research Group. Retinal vessel caliber among people with AIDS: Relationships with visual function. Am J Ophthalmol. 153: 428-433, 2012.
  • Gangaputra S Won Pak J Peng Q Hubbard LD Thayer D Krason Z Joyce J Danis RP; for the Studies of Ocular Complications of AIDS Research Group. Transition from film to digital fundus photography in the Longitudinal Studies of Ocular Complications of AIDS. Retina. 3200: 600-605, 2012.
  • Gangaputra S Kalyani PS Fawzi AA Van Natta ML Hubbard LD Danis RP Thorne JE Holland GN; on behalf of the Studies of Ocular Complications of AIDS Research Group. Retinal vessel caliber among people with AIDS: Relationship with disease-associated factors and mortality. Am J Ophthalmol. 153: 434-444, 2012.
  • Kay CN Pavan PR Small LB Zhang T Zamba GK Cohen SM. Familial trends in a population with macular holes. Retina.. 32(4) : 754-9, 2012.
  • Sugar EA Jabs DA Altaweel MM Lightman S Acharya N Vitale AT Thorne JE; Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. Identifying a Clinically Meaningful Threshold for Change in Uveitic Macular Edema Evaluated by Optical Coherence Tomography Am J Ophthalmol. 153(6) : 1044-1052.e5, 2011.
  • Gangaputra SS Altaweel MM Peng Q Friedman DS Rao PK Foster CS Kim RY Reed SB Srivastava SK Wong IG Kempen J. MUST Trial Research Group.Morphologic assessment for glaucoma in the Multicenter Uveitis Steroid. Ocul Immunol Inflamm.. 19(4) : 267-74, 2011.
  • Holbrook JT Kempen JH Prusakowski NA Altaweel MM Jabs DA; for the Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. Challenges in the design and implementation of the Multicenter Uveitis Steroid Treatment (MUST) Trial - lessons for comparative effectiveness trials. Clin Trials. 8(6) : 736-743, 2011.
  • Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group Kempen JH Altaweel MM Holbrook JT Jabs DA Louis TA Sugar EA Thorne JE. Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial. Ophthalmology.. 118(10) : 1916-26, 2011.
  • Holbrook JT Kempen JH Prusakowski NA Altaweel MM Jabs DA. Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group. Challenges in the design and P.R. PAVAN, M.D. 21 implementation of the Multicenter Uveitis Steroid Treatment (MUST) Trial--lessons for comparative effectiveness trials. Clin Trials. 8(6) : 736-43, 2011.
  • Kay CN, Saunders TS, Pavan PR. Ocular injuries sustained in paintball trauma. Graefe''s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. 248(3) : 331-2, 2010.
  • Multicenter Uveitis Steroid Treatment Trial Research Group Kempen JH Altaweel MM Holbrook JT Jabs DA Sugar EA. The multicenter uveitis steroid treatment trial: rationale, design, and baseline characteristics. AM J Ophthalmol. 149(4) : 550-561, 2010.
  • Kay CN, Pavan PR, Burrows A, Martino AZ. Neurosensory retinal detachment of the macula in retinal phototoxicity documented by optical coherence tomography. Retinal cases & brief reports. 4(2) : 143-5, 2010.
  • Witmer MT, Pavan PR, Fouraker BD, Levy-Clarke GA. Acute retinal necrosis associated optic neuropathy. Acta ophthalmologica. , 2010.
  • Pavan PR. Endophthalmitis: management 25 years ago. Retina (Philadelphia, Pa.). 26(6 Suppl) : S45-6, 2006.
  • Malone JI, Morrison AD, Pavan PR, Cuthbertson DD. Prevalence and significance of retinopathy in subjects with type 1 diabetes of less than 5 years'' duration screened for the diabetes control and complications trial. Diabetes care. 24(3) : 522-6, 2001.
  • Arango JL, Pavan PR. Diabetic retinopathy treatment trials: a review. International ophthalmology clinics. 38(2) : 123-54, 1998.
  • Ormerod LD, Skolnick KA, Menosky MM, Pavan PR, Pon DM. Retinal and choroidal manifestations of cat-scratch disease. Ophthalmology. 105(6) : 1024-31, 1998.
  • Ormerod LD, Larkin JA, Margo CA, Pavan PR, Menosky MM, Haight DO, Nadler JP, Yangco BG, Friedman SM, Schwartz R, Sinnott JT. Rapidly progressive herpetic retinal necrosis: a blinding disease characteristic of advanced AIDS. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 26(1) : 34-45; discussion 46-7, 1998.
  • Grizzard WS, Kirk NM, Pavan PR, Antworth MV, Hammer ME, Roseman RL. Perforating ocular injuries caused by anesthesia personnel. Ophthalmology. 98(7) : 1011-6, 1991.
  • Biersdorf WR, Malone JI, Pavan PR, Lowitt S. Cone electroretinograms and visual acuities of diabetic patients on sorbinil treatment. Documenta ophthalmologica. Advances in ophthalmology. 69(3) : 247-54, 1988.
  • Margo CE, Pavan PR, Groden LR. Chronic vitritis with macrophagic inclusions. A sequela of treated endophthalmitis due to a coryneform bacterium. Ophthalmology. 95(2) : 156-61, 1988.
  • Margo CE, Pavan PR, Gendelman D, Gragoudas E. Bilateral melanocytic uveal tumors associated with systemic non-ocular malignancy. Malignant melanomas or benign paraneoplastic syndrome? Retina (Philadelphia, Pa.). 7(3) : 137-41, 1987.
  • Pavan PR, Aiello LM, Wafai MZ, Briones JC, Sebestyen JG, Bradbury MJ. Optic disc edema in juvenile-onset diabetes. Archives of ophthalmology. 98(12) : 2193-5, 1980.
  • Wise TG, Pavan PR, Ennis FA. Herpes simplex virus vaccines. The Journal of infectious diseases. 136(5) : 706-11, 1977.
  • Pavan PR, Ennis FA. The elimination of herpes simplex plaques by antibody and the emergence of resistant strains. Journal of immunology (Baltimore, Md. : 1950). 118(6) : 2167-75, 1977.
  • Pavan PR. Laboratory techniques in ocular virology. International ophthalmology clinics. 15(4) : 1-18, 1975.