Otolaryngology - Head & Neck Surgery

Publications 2009 to Present 

Sakai Y, Sokolowski BHA (2014) The BK channel affects extrinsic and intrinsic mechanisms of apoptosis. J Neurosci Res. In press.

Peng Z, Sakai Y, Kurgan Y, Sokolowski B, Uversky VN (2014) Intrinsic disorder in the BK channel and its interactome. PLoS One 9(4): e94331 Epub April 11.

Darville L, Sokolowski BHA (2014) Bottom-up and shotgun proteomics to identify a comprehensive cochlear proteome. J Vis Exp. (85):Epub Mar 7.

Ding B, Frisina RD, Zhu X, Sakai Y, Sokolowski B, Walton JP (2014) Direct control of Na+-K+-2Cl- co-transport protein (NKCC1) expression with aldosterone: Biotherapeutic implications. Am J Physiol. 306(1):C66-75. Epub 2013 Oct 3.

Darville L, Sokolowski BHA (2013) In-depth proteomic analysis of mouse cochlear sensory epithelium by mass spectrometry. J Proteome Res. 12(8):3620-3630.

Sokolowski S, Harvey MC, Sakai Y, Jordan A, Sokolowski BHA (2012) The large conductance calcium-activated K(+) channel interacts with the small GTPase Rab11b. Biochem Biophys Res Commun. 426:221-225.

Sokolowski BHA, Orchard S, Harvey M, Sridhar S, Sakai Y (2011) Conserved BK interactions relevant to cell death and survival. PLoS One 6(12):e28532. Epub Dec 9.

Sakai Y, Harvey M, Sokolowski BHA (2011) Identification and quantification of full-length BK channel variants in the developing mouse cochlea. J Neurosci Res. 89:1747–1760.

Kathiresan T, Orchard S, Harvey MC, Sokolowski BHA (2009) A protein interaction network for the large conductance Ca2+-activated K+ channel in the mouse cochlea. Mol Cell Proteomics. 8(8):1972-1987.

Sokolowski B, Duncan RK, Chen S, Karolat J, Kathiresan T, Harvey M. (2009) The large conductance Ca2+-activated K+ channel interacts with the apolipoprotein ApoA1. Biochem Biophys Res Commun. 387(4):671-675.

Kathiresan T, Harvey MC, Sokolowski BH. (2009) The use of 2-D gels to identify novel protein-protein interactions in the cochlea. Methods Mol Biol. 493:269-286.

Harvey MC, Sokolowski BH. (2009) In vivo verification of protein interactions in the inner ear by coimmunoprecipitation. Methods Mol Biol. 493:299-310.

Harvey MC, Karolat J, Sakai Y, Sokolowski BHA (2009) PPTX a pentraxin domain-containing protein interacts with the T1 domain of Kv4. J Neurosci Res. 87(8):1841-1847.

Photograph of a receptor cell, known as an outer hair cell (OHC), in the mammalian cochlea with its large nucleus (N) located at the base of the cell. Receptor cells in the cochlea have structures known as stereocilia (S) at their apex. These structures convert the mechanical energy of sound to an electrochemical signal that can be processed by the peripheral and central auditory nerves. Outer hair cells have an additional feature; they can contract and extend in response to hyper- and depolarization of the cell. Their motility is regulated by signals from the brain, thereby allowing for the fine-tuning of mechanical signals that impinge on the cochlea. The photo was taken at a magnification of 7100 X using an electron microscope by Margaret Harvey, Senior Biological Scientist. Check out the link to see an outer hair cell’s response to music: https://www.youtube.com/watch?v=c91ubWbScs4