USF Genomics
Larry Dishaw – PhD
Immunological Mechanisms of The Gut Microbiome
Dr. Dishaw is an associate professor in the Morsani College of Medicine. His main research, using non-traditional animal models, focuses on characterizing novel forms of innate immunity and the molecular phylogeny of immune responses in the gut. His long-term objectives utilize genomics and transcriptomics approaches, as well as experimental biology, to study host-microbiome interactions. The Dishaw lab aims to define conserved phylogenic signals shaping the stability of microbial community dynamics at mucosal surfaces by investigating how host immunity and exogenous factors (like viruses that infect bacteria, or phages) of the gut ecosystem shape the microbiome. He works to reveal how this dynamic relationship at the mucosal surface of the gut relates to chronic health conditions such as Inflammatory Bowel Disease (IBD).
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Publications
- Liberti, A., Natarajan, O., Atkinson, C., & Dishaw, L. J. (2022). Secreted immunoglobulin domain effector molecules of invertebrates and management of gut microbial ecology. Immunogenetics, 74(1), 99–109. https://doi.org/10.1007/s00251-021-01237-2
- Liberti, A., Leigh, B. A., Graham, Z., Natarajan, O., & Dishaw, L. J. (2022). A Role for Secreted Immune Effectors in Microbial Biofilm Formation Revealed by Simple In Vitro Assays. Methods in molecular biology (Clifton, N.J.), 2421, 127–140. https://doi.org/10.1007/978-1-0716-1944-5_9
- Liberti, A., Natarajan, O., Atkinson, C., Sordino, P., & Dishaw, L. J. (2021). Reflections on the Use of an Invertebrate Chordate Model System for Studies of Gut Microbial Immune Interactions. Frontiers in immunology, 12, 642687. https://doi.org/10.3389/fimmu.2021.642687
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Groer, M., Miller, E. M., Sarkar, A., Dishaw, L. J., Dutra, S. V., Youn Yoo, J., Morgan, K., Ji, M., & Ho, T. (2020). Predicted Metabolic Pathway Distributions in Stool Bacteria in Very-Low-Birth-Weight Infants: Potential Relationships with NICU Faltered Growth. Nutrients, 12(5), 1345. https://doi.org/10.3390/nu12051345
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Ho, T., Kumar, A., Louis-Jacques, A. F., Dishaw, L. J., Yee, A. L., & Groer, M. W. (2020). The development of intestinal dysbiosis in anemic preterm infants. Journal of perinatology : official journal of the California Perinatal Association, 40(7), 1066–1074. https://doi.org/10.1038/s41372-020-0599-z
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Groer, M. W., Miller, E. M., D'Agata, A., Ho, T., Dutra, S. V., Yoo, J. Y., Yee, A. L., Gilbert, J. A., & Dishaw, L. J. (2020). Contributors to Dysbiosis in Very-Low-Birth-Weight Infants. Journal of obstetric, gynecologic, and neonatal nursing : JOGNN, 49(3), 232–242. https://doi.org/10.1016/j.jogn.2020.02.003
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Liberti, A., Cannon, J. P., Litman, G. W., & Dishaw, L. J. (2019). A Soluble Immune Effector Binds Both Fungi and Bacteria via Separate Functional Domains. Frontiers in immunology, 10, 369. https://doi.org/10.3389/fimmu.2019.00369
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Leigh BA, Breitbart M, Oksanen HM, Bamford DH, Dishaw LJ. Genome Sequence of PM2-Like Phage Cr39582, Induced from a Pseudoalteromonas sp. Isolated from the Gut of Ciona robusta. Genome Announc. 2018 May 24;6(21). pii: e00368-18. doi: 10.1128/genomeA.00368-18. PubMed PMID: 29798916; PubMed Central PMCID: PMC5968719.
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Liberti A, Zucchetti I, Melillo D, Skapura D, Shibata Y, De Santis R, Pinto MR, Litman GW, Dishaw LJ. Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis. Biol Open. 2018 Jan 17;7(1). pii: bio029355. doi: 10.1242/bio.029355. PubMed PMID: 29222175; PubMed Central PMCID: PMC5827265.
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Leigh BA, Djurhuus A, Breitbart M, Dishaw LJ. The gut virome of the protochordate model organism, Ciona intestinalis subtype A. Virus Res. 2018 Jan 15;244:137-146. doi: 10.1016/j.virusres.2017.11.015. Epub 2017 Nov 15. PubMed PMID: 29155033.
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Leigh B, Karrer C, Cannon JP, Breitbart M, Dishaw LJ. Isolation and Characterization of a Shewanella Phage-Host System from the Gut of the Tunicate, Ciona intestinalis. Viruses. 2017 Mar 22;9(3). pii: E60. doi: 10.3390/v9030060. PubMed PMID: 28327522; PubMed Central PMCID: PMC5371815.
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Leigh BA, Liberti A, Dishaw LJ. Generation of Germ-Free Ciona intestinalis for Studies of Gut-Microbe Interactions. Front Microbiol. 2016 Dec 27;7:2092. doi: 10.3389/fmicb.2016.02092. eCollection 2016. PubMed PMID: 28082961; PubMed Central PMCID: PMC5186754.
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Dishaw LJ, Leigh B, Cannon JP, Liberti A, Mueller MG, Skapura DP, Karrer CR, Pinto MR, De Santis R, Litman GW. Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria. Nat Commun. 2016 Feb 15;7:10617. doi: 10.1038/ncomms10617. PubMed PMID: 26875669; PubMed Central PMCID: PMC4757023.
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