USF Genomics
Kami Kim
Pathogenesis of toxoplasmosis and malaria
Dr. Kami Kim is a physician-scientist who joined the USF faculty in 2017 as a Professor of Internal Medicine (Infectious Diseases and International Medicine) and Professor of Global Health. Her laboratory focuses upon understanding the pathogenesis of toxoplasmosis and malaria, parasitic diseases of global significance. The Toxoplasma projects use a multidisciplinary systems biology approach to understand how the parasite senses and responds to changes in its host. Using a combination of epigenomics, genetics and proteomics, her group is studying how the parasite transitions from the pathogenic tachyzoite form to the persistent bradyzoite form. She is investigating the epigenetic and genetic factors that govern the host response to parasites.
Dr. Kim has worked with Plasmodium falciparum and Plasmodium yoelii, a rodent malaria, to develop new malaria drug treatments and to understand malaria virulence. More recently she has developed collaborations with clinical investigators at the Blantyre Malaria Project in Malawi to understand parasite and host factors that contribute to pathogenesis of severe malaria. She is also interested in the impact of HIV and other viral infections upon the clinical course of malaria.
In addition to running her laboratory, Dr. Kim is a practicing infectious diseases physician. She is a Section Editor for PloS Pathogens, Editor for International Journal of Infectious Diseases, Editor for the Sanford Guide for Antibiotic Therapy, a standing member of the NIH PTHE study section, and a member of the Scientific Advisory Board for the Burroughs Wellcome Fund Postdoctoral Enrichment Program. Her work is supported by the NIH.
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Publications
- Nardelli, S. C., Silmon de Monerri, N. C., Vanagas, L., Wang, X., Tampaki, Z., Sullivan, W. J., Jr, Angel, S. O., & Kim, K. (2022). Genome-wide localization of histone variants in Toxoplasma gondii implicates variant exchange in stage-specific gene expression. BMC genomics, 23(1), 128. https://doi.org/10.1186/s12864-022-08338-6
- Miao, J., Wang, C., Lucky, A. B., Liang, X., Min, H., Adapa, S. R., Jiang, R., Kim, K., & Cui, L. (2021). A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum. PLoS pathogens, 17(8), e1009351. https://doi.org/10.1371/journal.ppat.1009351
- Decker, S. J., Goldstein, T. A., Ford, J. M., Teng, M. N., Pugliese, R. S., Berry, G. J., Pettengill, M., Silbert, S., Hazelton, T. R., Wilson, J. W., Shine, K., Wang, Z. X., Hutchinson, M., Castagnaro, J., Bloom, O. E., Breining, D. A., Goldsmith, B. M., Sinnott, J. T., O'Donnell, D. G., Crawford, J. M., … Kim, K. (2021). 3-Dimensional Printed Alternative to the Standard Synthetic Flocked Nasopharyngeal Swabs Used for Coronavirus Disease 2019 Testing. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 73(9), e3027–e3032. https://doi.org/10.1093/cid/ciaa1366
- Gibbons, J., Qin, J., Malla, P., Wang, Z., Brashear, A., Wang, C., Miao, J., Adams, J. H., Kim, K., Jiang, R., & Cui, L. (2020). Lineage-Specific Expansion of Plasmodium falciparum Parasites With pfhrp2 Deletion in the Greater Mekong Subregion. The Journal of infectious diseases, 222(9), 1561–1569. https://doi.org/10.1093/infdis/jiaa250
- Francia, M. E., Bhavsar, S., Ting, L. M., Croken, M. M., Kim, K., Dubremetz, J. F., & Striepen, B. (2020). A Homolog of Structural Maintenance of Chromosome 1 Is a Persistent Centromeric Protein Which Associates With Nuclear Pore Components in Toxoplasma gondii. Frontiers in cellular and infection microbiology, 10, 295. https://doi.org/10.3389/fcimb.2020.00295
- Harawa, V., Njie, M., Keller, T., Kim, K., Jaworowski, A., Seydel, K., Rogerson, S. J., & Mandala, W. (2019). Malawian children with uncomplicated and cerebral malaria have decreased activated Vγ9Vδ2 γδ T cells which increase in convalescence. PloS one, 14(10), e0223410. https://doi.org/10.1371/journal.pone.0223410
- Duffy, F., Bernabeu, M., Babar, P. H., Kessler, A., Wang, C. W., Vaz, M., Chery, L., Mandala, W. L., Rogerson, S. J., Taylor, T. E., Seydel, K. B., Lavstsen, T., Gomes, E., Kim, K., Lusingu, J., Rathod, P. K., Aitchison, J. D., & Smith, J. D. (2019). Meta-analysis of Plasmodium falciparum var Signatures Contributing to Severe Malaria in African Children and Indian Adults. mBio, 10(2), e00217-19. https://doi.org/10.1128/mBio.00217-1
- El Bissati, K., Redel, H., Ting, L. M., Lykins, J. D., McPhillie, M. J., Upadhya, R., Woster, P. M., Yarlett, N., Kim, K., & Weiss, L. M. (2019). Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations. Frontiers in cellular and infection microbiology, 9, 9. https://doi.org/10.3389/fcimb.2019.00009
- Jeffers V, Tampaki Z, Kim K, Sullivan WJ Jr. A latent ability to persist: differentiation in Toxoplasma gondii. Cellular and molecular life sciences : CMLS. 2018; 75(13):2355-2373. NIHMSID: NIHMS956163 PMID:29602951, PMCID: PMC5988958
- Kim K. The Epigenome, Cell Cycle, and Development in Toxoplasma. Annual review of microbiology. 2018; PMID: 29932347
- Kessler A, Campo JJ, Harawa V, Mandala WL, Rogerson SJ, Mowrey WB, Seydel KB, Kim K. Convalescent Plasmodium falciparum-specific seroreactivity does not correlate with paediatric malaria severity or Plasmodium antigen exposure. Malaria journal. 2018; 17(1):178. PMID: 29695240, PMCID: PMC5918990
- Kessler A, Dankwa S, Bernabeu M, Harawa V, Danziger SA, Duffy F, Kampondeni SD, Potchen MJ, Dambrauskas N, Vigdorovich V, Oliver BG, Hochman SE, Mowrey WB, MacCormick I, Mandala WL, Rogerson SJ, Sather DN, Aitchison JD, Taylor TE, Seydel KB, Smith JD, Kim K. Linking EPCR-binding PfEMP-1 to brain swelling in pediatric cerebral malaria Cell Host Microbe. 22(5) : 601-614, 2017.
- Madaline TF, Hochman SE, Seydel KB, Liomba A, Saidi A, Matebule G, Mowrey WB, O'Hare B, Milner DA Jr, Kim K Rapid Diagnostic Testing of Hospitalized Malawian Children Reveals Opportunities for Improved HIV Diagnosis and Treatment Am J Trop Med Hyg. 97(6) : 1929-1935, 2017.
- Wijetunga NA, Johnston AD, Maekawa R, Delahaye F, Ulahannan N, Kim K, Greally J SMITE: an R/Bioconductor package that identifies network modules by integrating genomic and epigenomic information BMC Bioinformatics. 18(1) : 41, 2017.
- Ames RY, Ting LM, Gendlina I, Kim K, Macian F The Transcription Factor NFAT1 Participates in the Induction of CD4(+) T Cell Functional Exhaustion during Plasmodium yoelii Infection Infect Immun. 85(9) , 2017.
- Yakubu RR, Silmon de Monerri NC, Nieves E, Kim K, Weiss L Comparative Monomethylarginine Proteomics Suggests that Protein Arginine Methyltransferase 1(PRMT1) is a Significant Contributor to Arginine Monomethylation in Toxoplasma gondii Mol Cell Proteomics. 16(4) : 567-580, 2017.
- Naumov A, Kratzer S, Ting LM, Kim K, Suvorova ES, White M The Toxoplasma Centrocone Houses Cell Cycle Regulatory Factors MBio. 8(4) , 2017.
- Kim K. AID-ing Signaling in Toxoplasma gondii. mBio. 2017; 8(4). PMID: 28743818, PMCID: PMC5527314
- Sugi T, Ma YF, Tomita T, Murakoshi F, Eaton MS, Yakubu R, Han B, Tu V, Kato K, Kawazu S, Gupta N, Suvorova ES, White MW, Kim K, Weiss LM. Toxoplasma gondii Cyclic AMP-Dependent Protein Kinase Subunit 3 Is Involved in the Switch from Tachyzoite to Bradyzoite Development. mBio. 2016; 7(3). PMID: 27247232, PMCID: PMC4895117
- El Bissati K, Suvorova ES, Xiao H, Lucas O, Upadhya R, Ma Y, Angeletti RH, White MW, Weiss LM, Kim K. Toxoplasma gondii Arginine Methyltransferase 1 (PRMT1) Is Necessary for Centrosome Dynamics during Tachyzoite Cell Division. mBio. 2016; 7(1):e02094-15. PMID: 26838719, PMCID: PMC4742710
- Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD. Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. Nature communications. 2016; 7:10147. PMID: 26738725, PMCID: PMC4729833
- Kim K. A Bradyzoite is a Bradyzoite is a Bradyzoite? Trends in parasitology. 2015; 31(12):610-612. NIHMSID: NIHMS731214 PMID: 26515047,PMCID: PMC4679416
- Silmon de Monerri NC, Yakubu RR, Chen AL, Bradley PJ, Nieves E, Weiss LM, Kim K. The Ubiquitin Proteome of Toxoplasma gondii Reveals Roles for Protein Ubiquitination in Cell-Cycle Transitions. Cell host & microbe. 2015; 18(5):621-33. NIHMSID: NIHMS802460 PMID: 26567513, PMCID: PMC4968887
- Hochman SE, Madaline TF, Wassmer SC, Mbale E, Choi N, Seydel KB, Whitten RO, Varughese J, Grau GE, Kamiza S, Molyneux ME, Taylor TE, Lee S, Milner DA Jr, Kim K. Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection. mBio. 2015;6(5):e01390-15. PMID: 26396242, PMCID: PMC4611030
- Miley GP, Pou S, Winter R, Nilsen A, Li Y, Kelly JX, Stickles AM, Mather MW, Forquer IP, Pershing AM, White K, Shackleford D, Saunders J, Chen G, Ting LM, Kim K, Zakharov LN, Donini C, Burrows JN, Vaidya AB, Charman SA, Riscoe MK. ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria. Antimicrobial agents and chemotherapy. 2015; 59(9):5555-60. PMID: 26124159, PMCID:PMC4538462
- Rhee DB, Croken MM, Shieh KR, Sullivan J, Micklem G, Kim K, Golden A. toxoMine: an integrated omics data warehouse for Toxoplasma gondii systems biology research. Database : the journal of biological databases and curation. 2015; 2015:bav066. PubMed [journal] PMID: 26130662, PMCID: PMC4485433
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