Wanling Xuan

Assistant Research Scientist, Medicine, Vascular Biology Center

Senior Research Associate, Medicine, Vascular Biology Center

Contact Info

• 12901 Bruce B. Downs Blvd, MDC2104 Tampa, FL 33612-4749
  Tampa FL 33612
• Academic Email: wxuan@usf.edu
• Academic Phone: (618) 413-1805
• View My C.V. | View My Website

Education

Interdisciplinary and Emerging Signature Programs

• Allergy, Immunology & Infectious Disease
• Biomedical Engineering & Nanomedicine
• Cardiovascular
• Cardiovascular Sciences
• Cellular and Molecular Biology

Research Interests

• My research is focusing on muscle regeneration in aging and dystrophic muscle using stem cells.
• Currently, the laboratory has four major research directions:
• 1. Regeneration of sarcopenic muscle with human induced pluripotent stem cells (iPSC) derived muscle progenitors and their extracellular vesicles;
• 2. Targeting smooth muscle cell phenotypic switching in cardiovascular disease using engineered extracellular vesicles;
• 3. Cardiac regeneration post-myocardial infarction using stem cells derived progenitors ;
• 4. To identify innovative approaches for rejuvenation of the aging heart using hibernator model, exercise model, organoids, iPSC platform, CRISPR-Cas9 screening library and single cell sequencing techniques.

Recent Publications

• Wang Y, Zhang Y, Wen Z, Tian B, Kao E, Liu X, Xuan W, Ordovas K, Saloner D, Liu J. Deep learning based fully automatic segmentation of the left ventricular endocardium and epicardium from cardiac cine MRI. Quantitative imaging in medicine and surgery. 11(4) : 1600-1612, 2021.
• Xuan W, Khan M, Ashraf M. Pluripotent stem cell-induced skeletal muscle progenitor cells with givinostat promote myoangiogenesis and restore dystrophin in injured Duchenne dystrophic muscle. Stem cell research & therapy. 12(1) : 131, 2021.
• Shen J, Ji Y, Xie M, Zhao H, Xuan W, Yin L, Yu X, Xu F, Su S, Nie J, Xie Y, Gao Q, Ma H, Ke X, Shi Z, Fu J, Liu Z, He Y, Xiang M. Cell-modified bioprinted microspheres for vascular regeneration. Materials science & engineering. C, Materials for biological applications. 112: 110896, 2020.
• Xuan W, Khan M, Ashraf M. Extracellular Vesicles From Notch Activated Cardiac Mesenchymal Stem Cells Promote Myocyte Proliferation and Neovasculogenesis. Frontiers in cell and developmental biology. 8: 11, 2020.
• Wang Y, Zhang Y, Xuan W, Kao E, Cao P, Tian B, Ordovas K, Saloner D, Liu J. Fully automatic segmentation of 4D MRI for cardiac functional measurements. Medical physics. 46(1) : 180-189, 2019.
• Xuan W, Wang L, Xu M, Weintraub NL, Ashraf M. miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart. Stem cells international. 2019: 3726392, 2019.
• Xuan W, Wang Y, Tang Y, Ali A, Hu H, Maienschein-Cline M, Ashraf M. Cardiac Progenitors Induced from Human Induced Pluripotent Stem Cells with Cardiogenic Small Molecule Effectively Regenerate Infarcted Hearts and Attenuate Fibrosis. Shock (Augusta, Ga.). 50(6) : 627-639, 2018.
• Xuan W, Huang W, Wang R, Chen C, Chen Y, Wang Y, Tan X. Elevated circulating IL-32 presents a poor prognostic outcome in patients with heart failure after myocardial infarction. International journal of cardiology. 243: 367-373, 2017.
• Hao H, Li X, Li Q, Lin H, Chen Z, Xie J, Xuan W, Liao W, Bin J, Huang X, Kitakaze M, Liao Y. FGF23 promotes myocardial fibrosis in mice through activation of β-catenin. Oncotarget. 7(40) : 64649-64664, 2016.
• Wei X, Wu B, Zhao J, Zeng Z, Xuan W, Cao S, Huang X, Asakura M, Xu D, Bin J, Kitakaze M, Liao Y. Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9. Circulation. 131(17) : 1506-17; discussion 1517, 2015.
• Chen C, Shen L, Cao S, Li X, Xuan W, Zhang J, Huang X, Bin J, Xu D, Li G, Kitakaze M, Liao Y. Cytosolic CARP promotes angiotensin II- or pressure overload-induced cardiomyocyte hypertrophy through calcineurin accumulation. PloS one. 9(8) : e104040, 2014.
• Liao Y, Bin J, Asakura M, Xuan W, Chen B, Huang Q, Xu D, Ledent C, Takashima S, Kitakaze M. Deficiency of type 1 cannabinoid receptors worsens acute heart failure induced by pressure overload in mice. European heart journal. 33(24) : 3124-33, 2012.
• Xuan W, Wu B, Chen C, Chen B, Zhang W, Xu D, Bin J, Liao Y. Resveratrol improves myocardial ischemia and ischemic heart failure in mice by antagonizing the detrimental effects of fractalkine*. Critical care medicine. 40(11) : 3026-33, 2012.
• Xuan W, Liao Y, Chen B, Huang Q, Xu D, Liu Y, Bin J, Kitakaze M. Detrimental effect of fractalkine on myocardial ischaemia and heart failure. Cardiovascular research. 92(3) : 385-93, 2011.
• Xie J, Liao Y, Yang L, Wu J, Liu C, Xuan W, Li M, Zhang L, Liu Y, Wu P, Bin J. Ultrasound molecular imaging of angiogenesis induced by mutant forms of hypoxia-inducible factor-1α. Cardiovascular research. 92(2) : 256-66, 2011.
• Yan Y, Liao Y, Yang L, Wu J, Du J, Xuan W, Ji L, Huang Q, Liu Y, Bin J. Late-phase detection of recent myocardial ischaemia using ultrasound molecular imaging targeted to intercellular adhesion molecule-1. Cardiovascular research. 89(1) : 175-83, 2011.
• Liao Y, Xuan W, Zhao J, Bin J, Zhao H, Asakura M, Funahashi T, Takashima S, Kitakaze M. Antihypertrophic effects of adiponectin on cardiomyocytes are associated with the inhibition of heparin-binding epidermal growth factor signaling. Biochemical and biophysical research communications. 393(3) : 519-25, 2010.

Positions Held

• assistant research scientist (Medicine, Vascular Biology Center, Medical College of Georgia 2020 - 2021)
• Senior Research Associate (Medicine, Vascular Biology Center, Medical College of Georgia 2018 - 2020)