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Directories

* (OBGYN Faculty Profile)

Ozlem Guzeloglu-Kayisli

Ozlem Guzeloglu-Kayisli, MSc, PhD

Contact Info

Education

  • PhD, Medical Biology, Akdeniz University, 2004
  • MSc, Medical Biology and Genetic, Akdeniz University, Institute of Health Science, 1998
  • BS, Molecular and Medical Biology,, Istanbul Uni Cerrahpasa Medical Faculty, 1994

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cellular and Molecular Biology
  • Women & Children's Health

Awards/Honors

  • Young Scientific Fellowship (European Human Genetics Conference - 2005)
  • President's Presenter Award (Society for Gynecologic Investigation - 2002)
  • President's Presenter Award (VII National Congress of Medical Biology - 2001)
  • Young Scientific Fellowship (International Congress of Human Genetics - 2001)
  • President’s Presenter Award (Society for Gynecologic Investigation - 2001)
  • Young Scientific Fellowship (EMBO - 1999)
  • Young Scientific Fellowship (NATO - 1998)
  • Summa Cum Laude (Istanbul University, Cerrahpasa Medical Faculty, Molecular and Medical Biology - 1994)

Recent Publications

  • Guzel E, Arlier S, Guzeloglu-Kayisli O, Tabak MS, Ekiz T, Semerci N, Larsen K, Schatz F, Lockwood CJ, Kayisli UA. Endoplasmic Reticulum Stress and Homeostasis in Reproductive Physiology and Pathology. International journal of molecular sciences. 18(4) , 2017.
  • Shapiro JP, Guzeloglu-Kayisli O, Kayisli UA, Semerci N, Huang SJ, Arlier S, Larsen K, Fadda P, Schatz F, Lockwood CJ. Thrombin impairs human endometrial endothelial angiogenesis; implications for progestin-only contraceptive-induced abnormal uterine bleeding. Contraception. 95(6) : 592-601, 2017.
  • Schatz F, Guzeloglu-Kayisli O, Arlier S, Kayisli UA, Lockwood CJ. The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Human reproduction update. 22(4) : 497-515, 2016.
  • Shapiro JP, Basar M, Kayisli UA, Guzeloglu-Kayisli O, Joseph Huang S, Suarez AA, Ozer HG, Schatz F, Lockwood CJ. Mass spectrometry identification of potential mediators of progestin-only contraceptive-induced abnormal uterine bleeding in human endometrial stromal cells. Contraception. 91(3) : 253-60, 2015.
  • Guzeloglu-Kayisli O, Kayisli UA, Semerci N, Basar M, Buchwalder LF, Buhimschi CS, Buhimschi IA, Arcuri F, Larsen K, Huang JS, Schatz F, Lockwood CJ. Mechanisms of chorioamnionitis-associated preterm birth: interleukin-1β inhibits progesterone receptor expression in decidual cells. The Journal of pathology. 237(4) : 423-34, 2015.
  • Schatz F, Guzeloglu-Kayisli O, Basar M, Buchwalder LF, Ocak N, Guzel E, Guller S, Semerci N, Kayisli UA, Lockwood CJ. Enhanced Human Decidual Cell-Expressed FKBP51 May Promote Labor-Related Functional Progesterone Withdrawal. The American journal of pathology. 185(9) : 2402-11, 2015.
  • Guzeloglu Kayisli O, Kayisli UA, Basar M, Semerci N, Schatz F, Lockwood CJ. Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding. PloS one. 10(10) : e0137855, 2015.
  • Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E. Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells. Fertility and sterility. 103(6) : 1469-76.e1-3, 2015.
  • Karakaya C, Guzeloglu-Kayisli O, Hobbs RJ, Gerasimova T, Uyar A, Erdem M, Oktem M, Erdem A, Gumuslu S, Ercan D, Sakkas D, Comizzoli P, Seli E, Lalioti MD. Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH. Molecular Human Reproduction. 20(7) : 630-43, 2014.
  • Ozturk S, Guzeloglu-Kayisli O, Lowther KM, Lalioti MD, Sakkas D, Seli E. Epab is dispensable for mouse spermatogenesis and male fertility. Molecular Reproduction and Development. 81(5) : 390, 2014.
  • Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-binding protein TIA-1 reduces cytokine expression in human endometrial stromal cells and is down-regulated in ectopic endometrium. The Journal of clinical endocrinology and metabolism. 99(12) : E2610-9, 2014.
  • Basar M, Bozkurt I, Guzeloglu-Kayisli O, Sozen B, Tekmen I, Schatz F, Arici A, Lockwood CJ, Kayisli UA. Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro. Fertility and sterility. 102(6) : 1777-84, 2014.
  • Guzeloglu-Kayisli O, Lalioti MD, Babayev E, Torrealday S, Karakaya C, Seli E. Human embryonic poly(A)-binding protein (EPAB) alternative splicing is differentially regulated in human oocytes and embryos. Molecular Human Reproduction. 20(1) : 59-65, 2014.
  • Guzeloglu-Kayisli O, Basar M, Shapiro JP, Semerci N, Huang JS, Schatz F, Lockwood CJ, Kayisli UA. Long-acting progestin-only contraceptives enhance human endometrial stromal cell expressed neuronal pentraxin-1 and reactive oxygen species to promote endothelial cell apoptosis. The Journal of clinical endocrinology and metabolism. 99(10) : E1957-66, 2014.
  • Lockwood CJ, Basar M, Kayisli UA, Guzeloglu-Kayisli O, Murk W, Wang J, De Paz N, Shapiro JP, Masch RJ, Semerci N, Huang SJ, Schatz F. Interferon-γ protects first-trimester decidual cells against aberrant matrix metalloproteinases 1, 3, and 9 expression in preeclampsia. The American journal of pathology. 184(9) : 2549-59, 2014.
  • Lockwood CJ, Huang SJ, Chen CP, Huang Y, Xu J, Faramarzi S, Kayisli O, Kayisli U, Koopman L, Smedts D, Buchwalder LF, Schatz F. Decidual cell regulation of natural killer cell-recruiting chemokines: implications for the pathogenesis and prediction of preeclampsia. The American Journal of Pathology. 183(3) : 841-56, 2013.
  • Kayisli UA, Guzeloglu-Kayisli O, Guzel E, Arici A. Genistein inhibits cell proliferation and stimulates apoptosis in human coronary artery endothelial cells. Gynecologic and obstetric investigation. 75(4) : 235-42, 2013.
  • Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E. Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary. Endocrinology. 154(10) : 3877-87, 2013.
  • Guzeloglu-Kayisli O, Lalioti MD, Aydiner F, Sasson I, Ilbay O, Sakkas D, Lowther KM, Mehlmann LM, Seli E. Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice. The Biochemical Journal. 446(1) : 47-58, 2012.
  • Ozturk S, Guzeloglu-Kayisli O, Demir N, Sozen B, Ilbay O, Lalioti MD, Seli E. Epab and Pabpc1 are differentially expressed during male germ cell development. Reproductive sciences (Thousand Oaks, Calif.). 19(9) : 911-22, 2012.
  • Cakmak H Guzeloglu-Kayisli O Kayisli UA Arici A. Immune-endocrine interactions in endometriosis. Front Biosci (Elite Ed).. 1(1) : 429-43, 2009.
  • Guzeloglu-Kayisli O, Kayisli UA Taylor HS. The role of growth factors and cytokines during implantation: endocrine and paracrine interactions. Semin Reprod Med. 27(1) : 62-7, 2009.
  • Seli E, Yaba A, Guzeloglu-Kayisli O, Lalioti MD. Alternative splicing of the mouse embryonic poly(A) binding protein (Epab) mRNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte. Molecular human reproduction. 14(7) : 393-8, 2008.
  • Guzeloglu-Kayisli O, Cetin Z, Keser I, Ozturk Z, Tuncer T, Canatan D, Luleci G. Relationship between SP1 polymorphism and osteoporosis in beta-thalassemia major patients. Pediatrics International. 50(4) : 474-6., 2008.
  • Guzeloglu-Kayisli O, Pauli S, Demir H, Lalioti MD, Sakkas D, Seli E. Identification and characterization of human embryonic poly(A) binding protein (EPAB). Molecular human reproduction. 14(10) : 581-8, 2008.
  • Guzeloglu-Kayisli O, Halis G, Taskiran S, Kayisli UA, Arici A. DNA-binding ability of NF-kappaB is affected differently by ERalpha and ERbeta and its activation results in inhibition of estrogen responsiveness. Reproductive sciences (Thousand Oaks, Calif.). 15(5) : 493-505, 2008.
  • Seli E, Guzeloglu-Kayisli O, Kayisli UA, Kizilay G, Arici A. Estrogen increases apoptosis in the arterial wall in a murine atherosclerosis model. Fertility and sterility. 88(4 Suppl) : 1190-6, 2007.
  • Guzeloglu-Kayisli O, Basar M, Arici A. Basic aspects of implantation. Reproductive biomedicine online. 15(6) : 728-39, 2007.
  • Keser I Manguoglu E Kayisli O Yesilipek A Luleci G . Combination of Hb Knossos [Cod 27 (G-T)] and IVSII-745 (C-G) in a Turkish patient with beta-thalassemia major. Genet Test.. 11(3) : 228-230., 2007.
  • Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam B, Arici A. Estradiol increases apoptosis in human coronary artery endothelial cells by up-regulating Fas and Fas ligand expression. The Journal of clinical endocrinology and metabolism. 91(12) : 4995-5001, 2006.
  • Guzeloglu-Kayisli O, Keser I, Canatan D, Şanlıoğlu A, D, Özeş NO, Lüleci G. Identification of a Novel Frameshift Mutation [Codon 3 (+T)] in a Turkish Patient with Beta- Thalassemia Intermedia Turkish J. Med. Sci.. 35: 175-177., 2005.
  • Keser I, Manguoğlu E, Guzeloglu-Kayisli O, Kurt F, Mendilcioğlu I, Şimşek M, Bağcı G, Küpesiz A, Lüleci G. Prenatal Diagnosis of Beta-Thalassemia in the Antalya Province. Turkish J. Med. Sci.. 35: 251-253., 2005.
  • Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A. Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window. Human reproduction (Oxford, England). 20(11) : 3012-7, 2005.
  • Güzeloğlu Kayışlı Ö, Keser İ, Özeş ON, Canatan D, Yeşilipek A, Lüleci G. Compound heterozygosity for two beta chain variants: the mildly unstable Hb Tyne (codon 5 Pro→Ser) and HbS (codon 6 Glu→Val). Turkish journal of haematology : official journal of Turkish Society of Haematology. 22(1) : 37-40, 2005.
  • Guzeloglu-Kayisli O, Amankulor NM, Voorhees J, Luleci G, Lifton RP, Gunel M. KRIT1/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex. Neurosurgery. 54(4) : 943-9; discussion 949, 2004.
  • Mulayim N, Savlu A, Guzeloglu-Kayisli O, Kayisli UA, Arici A. Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8. Fertility and sterility. 81 Suppl 1: 904-11, 2004.
  • Guzeloglu-Kayisli O, Kayisli UA, Amankulor NM, Voorhees JR, Gokce O, DiLuna ML, Laurans MS, Luleci G, Gunel M. Krev1 interaction trapped-1/cerebral cavernous malformation-1 protein expression during early angiogenesis. Journal of neurosurgery. 100(5 Suppl Pediatrics) : 481-7, 2004.
  • Berkkanoglu M, Guzeloglu-Kayisli O, Kayisli UA, Selam BF, Arici A. Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro. Molecular human reproduction. 10(6) : 393-8, 2004.
  • Guzeloglu Kayisli O, Kayisli UA, Luleci G, Arici A. In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent. Biology of reproduction. 71(3) : 714-21, 2004.
  • Keser I, Sanlioglu AD, Manguoglu E, Guzeloglu Kayisli O, Nal N, Sargin F, Yesilipek A, Simsek M, Mendilcioglu I, Canatan D, Luleci G. Molecular analysis of beta-thalassemia and sickle cell anemia in Antalya. Acta haematologica. 111(4) : 205-10, 2004.
  • Kayisli UA, Guzeloglu-Kayisli O, Arici A. Endocrine-immune interactions in human endometrium. Annals of the New York Academy of Sciences. 1034: 50-63, 2004.
  • Kayisli UA, Luk J, Guzeloglu-Kayisli O, Seval Y, Demir R, Arici A. Regulation of angiogenic activity of human endometrial endothelial cells in culture by ovarian steroids. The Journal of clinical endocrinology and metabolism. 89(11) : 5794-802, 2004.
  • Guzeloglu-Kayisli O, Amankulor NM Luleci G Lifton RP Gunel M, KRIT1/Cerebra. Cavernous Malformation 1 protein localizes to vascular endothelium, astrocytes, and pyramidal cells of the adult human cerebral cortex Neurosurgery.. 54: 943-949., 2004.
  • Guzeloglu-Kayisli O, Kayisli UA, Al-Rejjal R, Zheng W, Luleci G, Arici A. Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium. The Journal of clinical endocrinology and metabolism. 88(10) : 5017-26, 2003.
  • Kayisli UA, Selam B, Guzeloglu-Kayisli O, Demir R, Arici A. Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system. Journal of immunology (Baltimore, Md. : 1950). 171(5) : 2305-13, 2003.
  • Keser I, Canatan D, Güzeloglu-Kayişli O, Coşan R, Lüleci G. beta-Thalassemia major associated with Down syndrome. Annales de genetique. 44(2) : 57-8, 2001.
  • Keser I Kayisli OG Yesilipek A Ozes ON Luleci G. Hb Antalya [codons 3-5 (Leu-Thr-Pro-- >Ser-Asp-Ser)]: a new unstable variant leading to chronic microcytic anemia and high Hb A2 Hemoglobin.. 25: 369-373., 2001.
  • Senol U, Lüleci E, Keser I, Güzeloglu-Kayisli O, Toraman AD, Lüleci G, Canatan D. Sickle-beta-thalassemia and splenic calcification. Abdominal imaging. 26(5) : 557, 2001.

Positions Held

  • Assistant Professor (Ob&Gyn, Morsani College of Medicine, University of South Florida 2014 - 2018)
  • Assistant Professor (Ob&Gyn, Ohio State Uni College of Medicine 2012 - 2014)
  • Associate Research Scientist (Ob&Gyn, College of Medicine, Yale University 2011 - 2012)
  • Post Doctoral Associate (Ob&Gyn, College of Medicine, Yale University 2005 - 2011)