USF Heart Institute

Hua Pan

Hua Pan, MBA, PhD

Assistant Professor Biomedical, College of Medicine Internal Medicine

Contact Info 560 Channelside Drive
Tampa FL 33602

Academic Email:

Academic Phone:(813) 396-9755


  • MBA, Business Administration, Washington University in St. Louis, 2014
  • Phd, Biomedical Engineering, Washington University in St. Louis, 2007

Research Interests

  • Cancer-treatment induced cardiotoxicity is the leading cause of the mortality in more than 15.5 million cancer survivors. Moreover, the cardiotoxicity is the reason cancer patients could not continue receiving treatment. Research of my lab is focused on understanding the mechanism of cancer-treatment related cardiotoxicity through integrated omics-based approach and validating nano-scale platform treatment strategies to mitigate cardiotoxocity for cancer patients and survivors. My laboratory provides a multidisciplinary basic and applied research environment and training venue with a translational emphasis. Specific research focuses include:
  • 1. Mitigate cancer-treatment related vascular damage with anti-thrombotic interventions.
  • 2. Target the Nox2/4-oxidative stress axis for predicting and alleviating cardiomyocyte toxicity caused by anthracyclines.
  • 3. Target the inflammation signaling pathways for predicting and alleviating cardiotoxicity caused by immune checkpoint inhibitors.

Recent Publications

  • Yan H, Hu Y, Akk A, Rai MF, Pan H, Wickline SA, Pham CTN. Induction of WNT16 via Peptide-mRNA Nanoparticle-Based Delivery Maintains Cartilage Homeostasis. Pharmaceutics. 12(1) , 2020.
  • Wilson AJ, Zhou Q, Vargas I, Palekar R, Grabau R, Pan H, Wickline SA. Formulation and Characterization of Antithrombin Perfluorocarbon Nanoparticles. Methods in molecular biology (Clifton, N.J.). 2118: 111-120, 2020.
  • Zou W, Rohatgi N, Brestoff JR, Moley JR, Li Y, Williams JW, Alippe Y, Pan H, Pietka TA, Mbalaviele G, Newberry EP, Davidson NO, Dey A, Shoghi KI, Head RD, Wickline SA, Randolph GJ, Abumrad NA, Teitelbaum SL. Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure. The Journal of clinical investigation. , 2020.
  • Yan H, Duan X, Pan H, Akk A, Sandell LJ, Wickline SA, Rai MF, Pham CTN. Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery. Scientific reports. 9(1) : 442, 2019.
  • Mills KA, Quinn JM, Roach ST, Palisoul M, Nguyen M, Noia H, Guo L, Fazal J, Mutch DG, Wickline SA, Pan H, Fuh KC. p5RHH nanoparticle-mediated delivery of AXL siRNA inhibits metastasis of ovarian and uterine cancer cells in mouse xenografts. Scientific reports. 9(1) : 4762, 2019.
  • Rai MF, Pan H, Yan H, Sandell LJ, Pham CTN, Wickline SA. Applications of RNA interference in the treatment of arthritis. Translational research : the journal of laboratory and clinical medicine. 214: 1-16, 2019.
  • Zhou Q, Pan H, Li J. Molecular Insights into Potential Contributions of Natural Polyphenols to Lung Cancer Treatment. Cancers. 11(10) , 2019.
  • Yan H, Duan X, Collins KH, Springer LE, Guilak F, Wickline SA, Rai MF, Pan H, Pham CTN. Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury. Precision nanomedicine. 2(1) : 245-248, 2019.
  • Kabir AU Lee TJ Pan H Berry JC Krchma K Wu J Liu F Kang HK Hinman K Yang L Hamilton S Zhou Q Veis DJ Mecham RP Wickline SA Miller MJ Choi . Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis JCI Insight. , 2018.
  • Vemuri C, Upadhya GA, Arif B, Jia J, Lin Y, Gaut JP, Fazal J, Pan H, Wickline SA, Chapman WC. Antithrombin Perfluorocarbon Nanoparticles Improve Renal Allograft Function in a Murine Deceased Criteria Donor Model. Transplantation direct. 4(9) : e384, 2018.
  • Pan H, Palekar RU, Hou KK, Bacon J, Yan H, Springer LE, Akk A, Yang L, Miller MJ, Pham CT, Schlesinger PH, Wickline SA. Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice. International journal of nanomedicine. 13: 5187-5205, 2018.
  • Yan H Duan X Pan H Holguin N Rai MF Akk A Springer L Wickline SA Sandell LJ and Pham CTN. Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury. PNAS.. 113(41) : E6199-E6208., 2016.
  • Jallouk AP Palekar RU Marsh JN Pham CT Pan H Schlesinger PH Wickline SA. Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles. Bioconjug Chem.. , 2015.
  • Palekar RU Jallouk AP Goette MJ Chen J Myerson JW Allen JS Akk A Yang L Tu Y Miller MJ Pham CTN Wickline SA Pan H. Quantifying Progression and Regression of Thrombotic Risk in Experimental Atherosclerosis. FASEB J.. , 2015.
  • Pan H Myerson JW Hu L Marsh JN Hou K Scott MJ Allen JS Hu G San Roman S Lanza GM Schreiber RD Schlesinger PH and Wickline SA. Programmable nanoparticle functionalization for in vivo targeting. FASEB J.. 27: 255-64., 2013.
  • Hou KK Pan H Ratner L Schlesinger PH Wickline SA. Mechanisms of Nanoparticle Mediated siRNA Transfection by Melittin-Derived Peptides. ACS Nano.. 7(10) : 8605-15., 2013.
  • Pan H Ivashyna O Sinha B Lanza GM Ratner L Schlesinger PH Wickline SA. Post-formulation Peptide Drug Loading of Nanostructures for Metered Control of NF-κB Signaling. Biomaterials.. 32(1) : 231-238., 2011.
  • Wu D, Pan H Delaloye K Cui J. KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel function. Biophys J.. 99(11) : 3599-608., 2010.
  • Pan H Myerson JW Ivashyna O Soman NR Marsh JN Hood JL Lanza GM Schlesinger PH Wickline SA. Lipid membrane editing with peptide cargo linkers in cells and synthetic nanostructures. FASEB J.. 24(8) : 2928-37., 2010.
  • Silva JR Pan H Wu D Nekouzadeh A Decker KF Cui J Baker NA Sept D Rudy Y. A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Proc Natl Acad Sci USA.. 106(27) : 11102-6., 2009.