USF Heart Institute

Samuel Wickline

Samuel Wickline, MD

Associate Dean, College of Medicine Cardiology

Tgh Endowed Chair, Cardiovascular Medicine

Professor, Cardiovascular Sciences

Director, USF Health Heart Institute

Assoc. Dean & Professor, College of Medicine Internal Medicine

Contact Info 4001 E Fletcher Ave
Mail Point MDC 36
Tampa 33613

Academic Email:


  • MD, Medicine, University of Hawaii-Manoa, 1988
  • BA, Philosophy, Pomona College, 1974

Interdisciplinary and Emerging Signature Programs

  • Biomedical Engineering & Nanomedicine
  • Cardiovascular Sciences

Research Interests

  • My laboratory pursues basic and clinical research topics in molecular imaging and nanotechnology. We design novel methods, hardware, and software for clinical and molecular imaging with ultrasound and MRI. Cross disciplinary nanomedicine research is conducted with many collaborators. Current areas of research interest include:
  • 1. Development of molecularly targeted peptide nanostructures for control of gene function by delivery of oligonucleotides and mRNA to modulate inflammatory diseases.
  • 2. The design of theranostic biocompatible perfluorocarbon nanostructures for quantitative magnetic resonance imaging and delivery of pharmaceutical agents in atherosclerosis and heart failure.
  • 3. The design and synthesis of protease-activatible nanostructures for therapeutic use in metastatic cancer and atherosclerosis.
  • 4. The development of nanostructures that restore cellular autophagy in diseases such as muscular dystrophy and heart failure.

Recent Publications

  • Lozhkin A, Vendrov AE, Pan H, Wickline SA, Madamanchi NR, Runge MS. NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis. Journal of Molecular and Cellular Cardiology. 102: 10-21, 2017.
  • Thairu MW, Skidmore IH, Bansal R, Nováková E, Hansen TE, Li-Byarlay H, Wickline SA, Hansen AK. Efficacy of RNA interference knockdown using aerosolized short interfering RNAs bound to nanoparticles in three diverse aphid species. Insect Molecular Biology. 26(3) : 356-368, 2017.
  • Esser AK, Schmieder AH, Ross MH, Xiang J, Su X, Cui G, Zhang H, Yang X, Allen JS, Williams T, Wickline SA, Pan D, Lanza GM, Weilbaecher KN. Dual-therapy with αvβ3-targeted Sn2 lipase-labile fumagillin-prodrug nanoparticles and zoledronic acid in the Vx2 rabbit tumor model. Nanomedicine : Nanotechnology, Biology, and Medicine. 12(1) : 201-11, 2016.
  • Pan D, Pham CT, Weilbaecher KN, Tomasson MH, Wickline SA, Lanza GM. Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 8(1) : 85-106, 2016.
  • Palekar RU, Jallouk AP, Myerson JW, Pan H, Wickline SA. Inhibition of Thrombin With PPACK-Nanoparticles Restores Disrupted Endothelial Barriers and Attenuates Thrombotic Risk in Experimental Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 36(3) : 446-55, 2016.
  • Yan H, Duan X, Pan H, Holguin N, Rai MF, Akk A, Springer LE, Wickline SA, Sandell LJ, Pham CT. Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury. Proceedings of the National Academy of Sciences of the United States of America. 113(41) : E6199-E6208, 2016.
  • Palekar RU, Vemuri C, Marsh JN, Arif B, Wickline SA. Antithrombin nanoparticles inhibit stent thrombosis in ex vivo static and flow models. Journal of Vascular Surgery. 64(5) : 1459-1467, 2016.
  • Palekar RU, Jallouk AP, Goette MJ, Chen J, Myerson JW, Allen JS, Akk A, Yang L, Tu Y, Miller MJ, Pham CT, Wickline SA, Pan H. Quantifying progression and regression of thrombotic risk in experimental atherosclerosis. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 29(7) : 3100-9, 2015.
  • Pham CT, Pan H, Wickline SA. Peptide-siRNA nanotherapeutics in arthritis. Oncotarget. : 14731-14732, 2015.
  • Wang K, Pan D, Schmieder AH, Senpan A, Hourcade DE, Pham CT, Mitchell LM, Caruthers SD, Cui G, Wickline SA, Shen B, Lanza GM. Synergy between surface and core entrapped metals in a mixed manganese-gadolinium nanocolloid affords safer MR imaging of sparse biomarkers. Nanomedicine : Nanotechnology, Biology, and Medicine. 11(3) : 601-9, 2015.
  • Chen J, Vemuri C, Palekar RU, Gaut JP, Goette M, Hu L, Cui G, Zhang H, Wickline SA. Antithrombin nanoparticles improve kidney reperfusion and protect kidney function after ischemia-reperfusion injury. American journal of physiology. Renal physiology. 308(7) : F765-73, 2015.
  • Hughes MS, Marsh JN, Wickline SA, McCarthy JE. Additional results for "joint entropy of continuously differentiable ultrasonic waveforms" [J. Acoust. Soc. Am. 133(1), 283-300 (2013)]. The Journal of the Acoustical Society of America. 137(1) : 501, 2015.
  • Pan D, Kim B, Hu G, Gupta DS, Senpan A, Yang X, Schmieder A, Swain C, Wickline SA, Tomasson MH, Lanza GM. A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy. Nanomedicine (London, England). 10(2) : 241-51, 2015.
  • Pham CT, Pan H, Wickline SA. Peptide-siRNA nanotherapeutics in arthritis. Oncotarget. 6(17) : 14731-2, 2015.
  • Jallouk AP, Palekar RU, Pan H, Schlesinger PH, Wickline SA. Modifications of natural peptides for nanoparticle and drug design. Advances in Protein Chemistry and Structural Biology. 98: 57-91, 2015.
  • Jallouk AP, Palekar RU, Marsh JN, Pan H, Pham CT, Schlesinger PH, Wickline SA. Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles. Bioconjugate Chemistry. 26(8) : 1640-50, 2015.
  • Palekar RU, Jallouk AP, Lanza GM, Pan H, Wickline SA. Molecular imaging of atherosclerosis with nanoparticle-based fluorinated MRI contrast agents. Nanomedicine (London, England). 10(11) : 1817-32, 2015.
  • Hou KK, Pan H, Schlesinger PH, Wickline SA. A role for peptides in overcoming endosomal entrapment in siRNA delivery - A focus on melittin. Biotechnology advances. 33(6 Pt 1) : 931-40, 2015.
  • Goette MJ, Keupp J, Rahmer J, Lanza GM, Wickline SA, Caruthers SD. Balanced UTE-SSFP for 19F MR imaging of complex spectra. Magnetic Resonance in Medicine. 74(2) : 537-43, 2015.
  • Goette MJ, Lanza GM, Caruthers SD, Wickline SA. Improved quantitative (19) F MR molecular imaging with flip angle calibration and B1 -mapping compensation. Journal of Magnetic Resonance Imaging : JMRI. 42(2) : 488-94, 2015.
  • Hughes MS, McCarthy JE, Bruillard PJ, Marsh JN, Wickline SA. Entropy vs. Energy Waveform Processing: A Comparison Based on the Heat Equation. Entropy (Basel, Switzerland). 17(6) : 3518-3551, 2015.
  • Schmieder AH, Caruthers SD, Keupp J, Wickline SA, Lanza GM. Recent Advances in (19)Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions. Engineering (Beijing, China). 1(4) : 475-489, 2015.
  • Hu L, Wickline SA, Hood JL. Magnetic resonance imaging of melanoma exosomes in lymph nodes. Magnetic Resonance in Medicine. , 2014.
  • Bibee KP, Cheng YJ, Ching JK, Marsh JN, Li AJ, Keeling RM, Connolly AM, Golumbek PT, Myerson JW, Hu G, Chen J, Shannon WD, Lanza GM, Weihl CC, Wickline SA. Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 28(5) : 2047-61, 2014.
  • Myerson JW, He L, Allen JS, Williams T, Lanza G, Tollefsen D, Caruthers S, Wickline S. Thrombin-inhibiting nanoparticles rapidly constitute versatile and detectable anticlotting surfaces. Nanotechnology. 25(39) : 395101, 2014.
  • Jamis-Dow CA, Barbier GH, Watkins MP, Lanza GM, Caruthers SD, Wickline SA. Bicuspid Pulmonic Valve and Pulmonary Artery Aneurysm. Cardiology Research. 5(2) : 83-84, 2014.
  • Pan D, Schmieder AH, Wang K, Yang X, Senpan A, Cui G, Killgore K, Kim B, Allen JS, Zhang H, Caruthers SD, Shen B, Wickline SA, Lanza GM. Anti-angiogenesis therapy in the Vx2 rabbit cancer model with a lipase-cleavable Sn 2 taxane phospholipid prodrug using α(v)β₃-targeted theranostic nanoparticles. Theranostics. 4(6) : 565-78, 2014.
  • Jallouk AP, Moley KH, Omurtag K, Hu G, Lanza GM, Wickline SA, Hood JL. Nanoparticle incorporation of melittin reduces sperm and vaginal epithelium cytotoxicity. PloS One. 9(4) : e95411, 2014.
  • Schmieder AH, Wang K, Zhang H, Senpan A, Pan D, Keupp J, Caruthers SD, Wickline SA, Shen B, Wagner EM, Lanza GM. Characterization of early neovascular response to acute lung ischemia using simultaneous (19)F/ (1)H MR molecular imaging. Angiogenesis. 17(1) : 51-60, 2014.
  • Zhou HF, Yan H, Hu Y, Springer LE, Yang X, Wickline SA, Pan D, Lanza GM, Pham CT. Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide. ACS Nano. 8(7) : 7305-17, 2014.
  • Bulte JW, Schmieder AH, Keupp J, Caruthers SD, Wickline SA, Lanza GM. MR cholangiography demonstrates unsuspected rapid biliary clearance of nanoparticles in rodents: implications for clinical translation. Nanomedicine : nanotechnology, biology, and medicine. 10(7) : 1385-8, 2014.
  • Hou KK, Pan H, Lanza GM, Wickline SA. Melittin derived peptides for nanoparticle based siRNA transfection. Biomaterials. 34(12) : 3110-9, 2013.
  • Hughes MS, McCarthy JE, Marsh JN, Wickline SA. Joint entropy of continuously differentiable ultrasonic waveforms. The Journal of the Acoustical Society of America. 133(1) : 283-300, 2013.
  • Chen J, Pan H, Lanza GM, Wickline SA. Perfluorocarbon nanoparticles for physiological and molecular imaging and therapy. Advances in chronic kidney disease. 20(6) : 466-78, 2013.
  • Schmieder AH, Winter PM, Williams TA, Allen JS, Hu G, Zhang H, Caruthers SD, Wickline SA, Lanza GM. Molecular MR imaging of neovascular progression in the Vx2 tumor with αvβ3-targeted paramagnetic nanoparticles. Radiology. 268(2) : 470-80, 2013.
  • Pan D, Schirra CO, Wickline SA, Lanza GM. Multicolor computed tomographic molecular imaging with noncrystalline high-metal-density nanobeacons. Contrast media & molecular imaging. 9(1) : 13-25, 2013.
  • Palekar RU, Myerson JW, Schlesinger PH, Sadler JE, Pan H, Wickline SA. Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis. Molecular pharmaceutics. 10(11) : 4168-75, 2013.


  • Washington University Chancellors Award for Innovation and Entrepreneurship (Washington University - 2014)
  • James R. Hornsby Family Professor of Biomedical Science (Washington University - 2012)
  • Washington University Fellow Alumni Achievement Award (Washington University - 2012)
  • Faculty Leader of the Year (Washington University - 2010)
  • Established Investigator Award (American Heart Association - 1998)
  • Clinician-Scientist Award (American Heart Association - 1993)
  • Knowlton "Incentive for Excellence" Award (Washingon University School of Medicine - 1986)
  • Lange Award for Outstanding Student sophomore, junior, and senior years; (John A. Burns School of Medicine - 1980)
  • First Place - Presentation ofVectorcardiographic Infarct Sizing in Baboon (University of Hawaii - 1977)