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Clinical Trials

  • HEALEY ALS Platform Trial - Master Protocol

    - Enrolling May 2026!

    The HEALEY ALS Platform Trial is a research trial that tests the safety and effectiveness of multiple treatments in ALS. A regimen is a specific course of treatment, each with a different study drug. Multiple different regimens may be active within the platform trial at the same time. If you qualify for the platform trial, you will be randomly assigned to a regimen (one treatment). You will have an equal chance of being assigned to any active regimen. However, if you complete a regimen and then choose to participate in another regimen, you will not be randomized to your first regimen again. Within a regimen, you will have a 3 in 4 chance of being assigned to the active drug group, and a 1 in 4 chance of being assigned to the placebo group.

    For more information, please visit this website:  NCT04297683

    https://www.massgeneral.org/neurology/als/research/platform-trial

    To enroll in this study at USF please contact Sruthi Kommi Reddy at (813) 974-9413

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    COYA Therapeutics C302-CLN-2301 (ALSTARS)

    For more information, please visit this website: NCT07161999

    Enrolling now! To enroll in this study at USF please contact Shawn Nguyen at (813) 974-0284

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    PREVAiLS (Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS)

    For more information, please visit this website: NCT07322003

    Enrolling now! To enroll in this study at USF please contact Sruthi Kommi Reddy at (813) 974-9413

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    UNITE-ALS (Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis)

    For more information, please visit this website: NCT07023835

    Enrolling Fall 2026 - To enroll in this study at USF please contact Jessica Shaw at (813) 974-9413

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    Updated: April 2026

  • FA – ALCAR – Currently Enrolling

    The purpose of this study is to learn how treatment with acetyl-L-carnitine (ALCAR) will affect the hearts of patients with Friedreich's Ataxia as well as how it may affect other symptoms of Friedreich's Ataxia such as difficulties with balance, walking, or upper arm function.

     For more information please visit the website at https://clinicaltrials.gov/ct2/show/NCT01921868

    To enroll in this study at USF Health  please contact:
    Lucrectia Campbell or Paige Graham
    (813) 974-5909

    FA – Reata – Currently Enrolling

    This 2-part study will evaluate the efficacy, safety, and pharmacodynamics of omaveloxolone (RTA 408) in the treatment of patients with Friedreich's ataxia.

    For more information please visit the website at: https://clinicaltrials.gov/ct2/show/NCT02255435

    To enroll in this study at USF Health please contact:
    Lucrectia Campbell or Paige Graham
    (813) 974-5909

    FA – COMS – Currently Enrolling

    This is a long-term study of the natural progression of disease in Friedreich’s Ataxia (FA)

     

    To enroll in this study at USF Health  please contact:
    Lucretia Campbell or Paige Graham
    (813) 974-5909

    Retrotope RTMOTION – Ongoing Not Enrolling

    This is a study of a wearable gait device detecting movement in 3D in patients with movement disorders.

     

    To enroll in this study at USF Health please contact:
    Lecretia Campbell or Paige Graham
    (813) 974-5909

    SCA - IVIG 2014 – Currently Enrolling

    The purpose of this study is to learn how Intravenous Immune Globulin (IVIG) will affect Spinocerebellar Ataxia (SCA) symptoms and how it will affect motor and nervous system function in participants Subtypes of SCA to be examined will include SCA types 1, 2, 3, 6, 10 and 11.

    For more information please visit the website at:

    https://clinicaltrials.gov/ct2/show/NCT02287064

    To enroll in this study at USF Health please contact:
    Lucretia Campbell or Paige Graham
    (813) 974-5909

    FA - Gait and Balance – Currently Enrolling

    The purpose of this study is to assess gait and balance changes in Friedreich’s ataxia patients over the course of 12 months and correlate these changes to clinical measures of ataxia.

     

    To enroll in this study at USF Health please contact:
    Lucretia Campbell or Paige Graham
    (813) 974-5909

    PSP - BMS CN002-003 – Currently Enrolling

    The goal of this study is to evaluate the safety and tolerability of multiple doses of BMS-986168 in patients with PSP.

    For more information please visit the website at:

    https://clinicaltrials.gov/ct2/show/NCT02460094

    To enroll in this study at USF Health please contact:
    Lucretia Campbell or Paige Graham
    (813) 974-5909

    SCA - BHV4157-201 (Biohaven) – Start-up/Pending

    The purpose of this study is to compare the efficacy of BHV-4157 versus placebo on ataxia symptoms in subjects with spinocerebellar ataxia (SCA).

    For more information please visit the website at:

    https://clinicaltrials.gov/ct2/show/NCT02460094

    To enroll in this study at USF Health please contact:
    Lucretia Campbell or Paige Graham
    (813) 974-5909

    PSP - Abbvie M15-562 – Start-uo/Pending

    The purpose of this study is to assess the efficacy and long term safety and tolerability of ABBV-8E12 for up to 52 weeks in subjects with progressive supranuclear palsy (PSP).

     

    To enroll in this study at USF Health please contact: Lucretia Campbell or Paige Graham (813) 974-5909

  • CVL-865-SZ-001 (REALIZE) Currently Enrolling

    Research study testing an experimental drug called CVL-865 for adults (18 to 75 years old) with focal epilepsy who still experience seizures despite taking medication. The trial aims to determine if adding CVL-865 to current anti-seizure medications can improve seizure control while assessing safety.

    For more information on this study please visit the website: https://clinicaltrials.gov/study/NCT04244175?term=CVL-865-SZ-001&rank=1

    Realize Trial

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

    EQU2-02 (EQUILIBRIUM) Currently Enrolling

    Research study investigating an experimental drug called EQU-001 for adults (18 to 65 years old) with focal epilepsy who continue to have seizures despite medication. The trial aims to evaluate if adding EQU-001 to current anti-seizure medications can improve seizure control while ensuring safety.

    For more information on this study please visit the website: https://clinicaltrials.gov/study/NCT05473442?term=EQU-202%20EQUILIBRE&rank=1

    Equilibre Biopharmaceuticals Trial

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

    GWEP19022 (ILLUMINATE) Currently Enrolling

    Safety study for individuals with Lennox-Gastaut Syndrome, Dravet Syndrome, or Tuberous Sclerosis Complex who receive or will start Epidiolex therapy. The trial focuses on evaluating the safety of Epidiolex and monitoring any associated risks.

    For more information on this study please visit the website: https://clinicaltrials.gov/study/NCT05044819?term=GWEP19022&rank=1

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

    LP352-201 (LONGBOARD) Currently Enrolling

    Research study testing an experimental drug called LP352 for patients (12 to 65 years old) with Developmental and epileptic encephalopathy (DEE) such as Lennox-Gastaut Syndrome, Dravet Syndrome, and Tuberous Sclerosis Complex. The trial aims to determine if adding LP352 to current anti-seizure medications can improve seizure control

    For more information on this study please visit the website: https://clinicaltrials.gov/study/NCT05364021?term=LP352-201%20&rank=2

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

    YKP509C003 (CARISBAMATE) Currently Enrolling

    Research study investigating an experimental drug called YKP509 for individuals (4 to 55 years old) diagnosed with Lennox-Gastaut Syndrome and experiencing drop seizures. The trial aims to evaluate if adding YKP509 to current anti-seizure medications can effectively improve drop seizure control.

    For more information on this study please visit the website: https://clinicaltrials.gov/study/NCT05219617?term=YKP509C003&rank=1

    For additional information about potential enrollment please contact:
    Marina Azevedo: 813) 230-2323
    Ana Omura: (813) 259-8524

    NP100016 (NAUTILUS Trial) Currently Enrolling

    Research study assessing the effectiveness of a device called Responsive Neurostimulation System (RNS)* for individuals (12 years and older) with idiopathic generalized epilepsy (IGE) who experience generalized tonic-clonic seizures (GTCs). The trial evaluates if the RNS system, in addition to current anti-seizure medications, can improve seizure control. *The RNS system is currently FDA approved for patients diagnosed with focal epilepsy (when seizures come from one side of the brain).

    For more information on this study please visit the website: https://clinicaltrials.gov/study/NCT05147571?term=nautilus&rank=1

    NAUTILUS Epilepsy Study

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

    YKP3089C025 (Xcopri Trial) Currently Enrolling

    Research study investigating a drug called Cenobamate (Xcopri) for adults (18 years and older) diagnosed with idiopathic generalized epilepsy (IGE) and experiencing primary generalized tonic-clonic seizures (GTCs). The trial aims to determine if adding Cenobamate to current anti-seizure medications can improve seizure control.

    For more information on this study please visit the website: https://clinicaltrials.gov/study/NCT03678753?term=YKP3089C025&rank=2

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

    1024SE3003 (RAISE Trial) Currently Enrolling

    Research study testing an experimental drug called Ganaxolone for patients (12 years and older) diagnosed with Status Epilepticus (SE), a prolonged seizure condition. The trial assesses whether administering Intravenous (IV) Ganaxolone can effectively terminate ongoing seizure activity in individuals with Status Epilepticus, while monitoring safety.

    For more information on this study please visit the website: https://classic.clinicaltrials.gov/ct2/show/NCT04391569

    Marinus Pharmaceuticals

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

    EP0162 (STARS Trial) Currently Enrolling

    The STARS (Stand Together Against pRolonged Seizures) Research Study is a clinical trial for a drug called Alprazolam, which is sometimes used to treat seizures. This study aims to determine if Alprazolam, administered via a Staccato Inhaler Device, will work to stop prolonged seizures that last more than 3 minutes.

    For more information on this study please visit the website: https://clinicaltrials.gov/study/NCT05077904?term=EP0162%20STACCATO&rank=1

    UCB STARS Trial

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

    REMI-01-23 (REMI Trial) Currently Enrolling

    A study for adults aged 18 to 70 years old who have a history of seizures, including epileptic, non-epileptic or unknown seizures. Participants in this study experience seizures and their healthcare provider has recommended an at-home electroencephalogram (EEG). This study aims to investigate whether an extended EEG duration (REMI) yields a higher number of detected events compared to a standard EEG.

    For more information on this study please visit the website: https://clinicaltrials.gov/study/NCT05818930?term=remi%20epitel&rank=1

    Epitel

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

    STUDY005226 (NELLI Trial) Currently Enrolling

    This is a research study of an experimental device called Nelli for individuals who have a history of seizures with a motor component, including epileptic, non-epileptic or unknown seizures. Participants in this study experience seizures that involve some form of body movement, and their healthcare provider has recommended an at-home electroencephalogram (EEG) to monitor their brain activity during these episodes. The purpose of this study is assess if the NELLI artificial intelligence device can correctly identify seizures.

    For more information on this study please visit the website: https://www.neuroeventlabs.fi/

    For additional information about potential enrollment please contact:
    Marina Azevedo: (813) 230-2323
    Ana Omura: (813) 259-8524

  • Adult Facial Pain Trials

    NOE-TGN-201

    Libra

    (Currently Enrolling)

    A Phase II/III, Multicentre, 8-week Run-in Phase Followed by a 12-Week, Prospective, Parallel-group, Double-blind, Randomized Withdrawal, Placebo-controlled Study, with a 52-Week Open Label Extension, to Evaluate the Efficacy and Safety of Daily 1.5 to 3.5 mg Basimglurant in Patients with Pain Associated with Trigeminal Neuralgia with Suboptimal Response to their Current Anti-pain Therapy.

    For more information please contact:

    Allyssa Sawyer at (813) 396-2736

    Adult Headache Trials

    M21-307

    Preclude

    (Active - 
    Not Currently Enrolling)

    Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled Study of BOTOX (Botulinum Toxin Type A) for the Prevention of Migraine in Subjects with Episodic Migraine.

    For more information please contact:

    Allyssa Sawyer at (813) 396-2736

    Pediatric Headache Trials

    H8H-MC-LAHV

    PIONEER-PEDS1

    (Currently Enrolling)

    A Randomized, Double-Blind, Placebo-Controlled Study of Lasmiditan for Acute Treatment of Migraine: PIONEER-PEDS1.

    For more information please contact:

    Justis Root at (813) 396-2282

    H8H-MC-LAHW

    PIONEER-PEDS2

    (Currently Enrolling)

    A Phase 3, 12-Month, Open-Label Study of Lasmiditan in Pediatric Patients with Migraine - PIONEER-PEDS2.

    For more information please contact:

    Justis Root at (813) 396-2282

    I5Q-MC-CGAS

    REBUILD-1

    (Currently Enrolling)

    A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Patients 6 to 17 Years of Age with Episodic Migraine – the REBUILD-1 Study.

    For more information please contact:

    Justis Root at (813) 396-2282

    I5Q-MC-CGAT

    REBUILD-2

    (Currently Enrolling)

    A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Adolescent Patients 12 to 17 Years of Age with Chronic Migraine – the REBUILD-2 Study.

    For more information please contact:

    Justis Root at (813) 396-2282

    3110-305-002

    (Currently Enrolling)

    A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Single-attack Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Oral Ubrogepant in the Acute Treatment of Migraine With or Without Aura in Children and Adolescents (Ages 6-17).

    For more information please contact:

    Allyssa Sawyer at (813) 396-2736

    3110-306-002

    (Currently Enrolling)

    A Multicenter, Open-label, Extension Study to Evaluate the Long-term Safety and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine With or Without Aura in Children and Adolescents (Ages 6-17).

    For more information please contact:

    Allyssa Sawyer at (813) 396-2736

    P255-501 “ROAR”

    (Currently Enrolling)

    A Randomized, Double-Blind, Placebo-Controlled,

    Parallel-Group, Phase 4 Study to Evaluate the Efficacy and

    Safety of Qudexy® XR in the Prevention of Migraine in Children 6 to 11 Years of Age.

    For more information please contact:

    Allyssa Sawyer at (813) 396-2736

    19379A-Rejoin

    (Currently Enrolling)

    Long term, open label (dose blinded), extension study of eptinezumab in children and adolescents with chronic or episodic migraine.

    For more information please contact:

    Allyssa Sawyer at (813) 396-2736

    19357A- Prospect 1

    (Currently Enrolling)

    Interventional, randomized, double-blind, parallel-group,

    placebo-controlled study to evaluate the efficacy and safety of

    intravenous (IV) eptinezumab in pediatric patients (6 to

    17 years) for the preventive treatment of episodic migraine.

    For more information please contact:

    Allyssa Sawyer at (813) 396-2736

    19356A- Prospect 2

    (Currently Enrolling)

    Interventional, randomized, double-blind, parallel-group,

    placebo-controlled study to evaluate the efficacy and safety of IV

    eptinezumab in adolescents (12-17 years) for the preventive treatment of chronic migraine.

    For more information please contact:

    Allyssa Sawyer at (813) 396-2736

    CLIN-52120-463

    C-BEOND

     

    A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study with Extension Phase to Evaluate the Efficacy and Safety of Dysport for the Prevention of Chronic Migraine in Adult Participants.

     

    For more information please contact:

    Allyssa Sawyer at (813)396-2736

  • Enroll HD

    Currently Enrolling

    Enroll HD is an observational study for families effected by Huntington’s Disease. This study monitors how the disease materializes and changes over time in different individuals. This study is open to people with HD, as well as, those who are at-risk. The Enroll HD study is intended to speed up discoveries and develop new therapies for Huntington’s Disease.

    For more information on this study please visit the Enroll-HD’s website at: www.enroll-hd.org

    To enroll in this study or if you have any questions please contact Ruth Cajuste at 813-396-2155 or Kelly Elliot at 813-974-6022

    Invest HD

    Currently Enrolling 

    A Randomized, Placebo-controlled, Double-blind Phase 3 Study to Evaluate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease. The purpose is to assess safety and tolerability of votoplam and to determine whether votoplam slows disease progression in patients with early symptomatic Huntington's disease (HD) compared to the control arm.

    For more information please visit here.

    To enroll in this study or if you have any questions please contact Ruth Cajuste at 813-396-2155.

  • BALANCE-MSS1

    Currently enrolling

    This is a phase 2, randomized, double-Blind, four-arm, placebo-controlled, multicenter study assessing the efficacy, safety and tolerability of three doses of orally administered BMS-986368, a FAAH/MAGL Inhibitor, for the treatment of spasticity in participants with multiple sclerosis.

    For more information please visit here.

    To enroll in this study please contact Amber McPherson at (813) 974-9423

    ENHANCE

    Currently enrolling

    This is an open-label trial evaluating the efficacy when transitioning from current anti-CD20 therapy to ublituxumab.

    For more information please visit here.

    To enroll in this study please contact Amber McPherson at (813) 974-9423

    IM047-050

    Currently enrolling 

    This phase 3 double-blind study is evaluating the efficacy and safety of oral ozanimod compared to oral fingolimod in children and adolescents with relapsing remitting Multiple Sclerosis

    For more information please visit here. 

    To enroll in this study please contact Amber McPherson at (813) 974-9423

    Monarch

    Currently enrolling

    This is phase 3, randomized, double-blind, efficacy and safety study comparing orelabrutinib to placebo in patients with non-active secondary progressive multiple sclerosis.

    For more information please visit here.

     To enroll in this study please contact Amber McPherson at (813) 974-9423

    OCTAVIBE

    Enrolling soon!  

                                         

    This phase 3, open-label, single-arm, multi-center study will evaluate the safety and use of an on-body delivery system for the subcutaneous administration of ocrelizumab in patients with multiple sclerosis

    For more information please visit here.

    To enroll in this study please contact Amber McPherson at (813) 974-9423

    POLARIS

    Enrolling soon!                                          

    This multicenter, randomized, double-Blinded, placebo-controlled, phase 2 trial will evaluate the efficacy, safety, and tolerability of subcontaneous efgartigimod ph20 in adult and adolescent aarticipants with autoimmune encephalitis

    For more information please visit here.

    To enroll in this study please contact Amber McPherson at (813) 974-9423

    PRIMROSE

    Currently enrolling                                             

     This is phase 3, randomized, double-blind, efficacy and safety study comparing orelabrutinib to placebo in patients with primary progressive multiple sclerosis

     For more information please visit here.

     To enroll in this study please contact Amber McPherson at (813) 974-9423

    REMASTER

    Currently Enrolling                                             

     This is A randomized, double-blind, placebo-controlled Phase III study to evaluate the efficacy and safety of remibrutinib in patients with secondary progressive multiple sclerosis

     For more information please visit here.

     To enroll in this study please contact Amber McPherson at (813) 974-9423

    RESHAPE

    Currently enrolling                                            

    This is a randomized, open-label, parallel-group, non-inferiority study comparing efficacy, safety, and tolerability of remibrutinib after switching from ocrelizumab in participants living with relapsing multiple sclerosis, followed by open-label treatment with remibrutinib

    For more information please visit here.

    To enroll in this study please contact Amber McPherson at (813) 974-9423

    SPHERE

    Currently enrolling                                             

    This registry aims to study the natural history of patients with neuromyelitis optica spectrum disorder(NMOSD), real-world effectivenss and safety of approved and off-label medications used in treatment of NMOSD and drug utlization treatment patterns

    For more information please visit here.

    To enroll in this study please contact Amber McPherson at (813) 974-9423

    Sun-627-MS202

    Currently enrolling

    This is phase 2a, randomized, placebo-controlled clinical trial is evaluating the safety and tolerability of SUN-627 in participants with non-active secondary progressive and primary progressive multiple sclerosis (SPMS/​PPMS).

    For more information please visit here. 

    To enroll in this study please contact Amber McPherson at (813) 974-9423

    Voyage

    Currently enrolling

    This is a phase 3 Study with an open-label extension in pediatric participants that will evaluate the safety, efficacy, and pharmacokinetics of diroximel fumarate and dimethyl fumarate

    For more information please visit here.

    To enroll in this study please contact Amber McPherson at (813) 974-9423

  • Myasthenia Gravis studies

    Updated April 2026

    Arcellx ARC-311 

    - Currently Enrolling

    This is an open-label study of anito-cel in subjects with generalized myasthenia gravis (gMG). Anito-cel is a BCMA-directed CAR-T cell therapy. This study will be conducted at USF Morsani Center in conjunction with Moffitt Cancer Center. 

    For more information, please visit: NCT06626919

     To enroll in this study at USF please contact Jessica Shaw at (813)974-9413.

    Janssen Pediatric MG (VIBRANCE)

    -Currently Enrolling

    The purpose of this study is to determine the effect of nipocalimab on total serum immunoglobulin G (IgG) in pediatric participants 2 to less than (<) 18 years of age, the safety and tolerability of treatment with nipocalimab in children and adolescents and to evaluate the pharmacokinetics (PK) of nipocalimab in children and adolescents with generalized myasthenia gravis (gMG) who have an insufficient clinical response to ongoing, stable standard-of-care therapy. 

    For more information, please visit:    

    NCT05265273

    https://globaltrialfinder.janssen.com/trial/CR109137

    To enroll in this study at USF please contact Jessica Shaw at (813)974-9413.

    MS700568_0183_ (MyClad)

    -Currently Enrolling

    The purpose of this clinical study is to determine the efficacy and safety of a new oral cladribine formulation in participants with Generalized Myasthenia Gravis (gMG) in comparison to placebo. It will also investigate the sustained efficacy, the need for retreatment, and the long-term safety of oral cladribine in gMG. An additional component is included to characterize the Pharmacokinetics (PK) of the new cladribine formulation in gMG participants. This study is divided into 3 periods: the double-blind placebo control (DBPC) pivotal period, and 2 extensions, the blinded extension (BE) and the retreatment (RT) period.

    For more information, please visit:

    NCT06463587

     To enroll in this study at USF please contact Jessica Shaw at (813)974-9413.

    NMD670-02-0002 (SYNAPSE-MG)

    -Currently Enrolling

    This Phase 2 proof-of-concept, dose range finding study aims to evaluate the safety and efficacy of 3 dose levels of NMD670 vs placebo in adult patients with MG with antibodies against AChR or MuSK, administered twice a day (BID) for 21 days.

    For more information, please visit:

    NCT06414954

     To enroll in this study at USF please contact Jessica Shaw at (813)974-9413.

     ARGX-999-2-MG-2000 (ADAPT FORWARD)

    -Currently Enrolling

    ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to reduce patients' side effects and improve their quality of life.

    For more information, please visit:

    NCT07294170
    To enroll in this study at USF please contact Jessica Shaw at (813)974-9413.
     

    RC18G006 (UPSTREAM MG)

    - Enrolling now! 

     A Study of Telitacicept for the Treatment of Generalized Myasthenia Gravis  For more information, please visit: NCT06456580  To enroll in this study at USF please contact Jessica Shaw at (813)974-9413.

    IMVT-1402-3101 (PROPEL) 

    - Enrolling now! 

    Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis  For more information, please visit: NCT07039916   To enroll in this study at USF please contact Jessica Shaw at (813)974-9413.
                  

    Neuropathy Studies - includes Multifocal Motor Neuropathy (MMN) and Chronic inflammatory demyelinating neuropathy (CIDP)

    Updated April 2026

    DNTH103-MMN-201 (MoMeNtum)

    -Currently Enrolling

    A phase 2 study to evaluate the safety, tolerability and effectiveness of DNTH103 in participants with multifocal motor neuropathy (MMN). DNTH103 is an investigational, clinical-stage, potent monoclonal antibody engineered to selectively target the classical pathway by inhibiting only the active form of the C1s protein, a clinically validated complement target. 

    For more information, please visit:

    NCT06537999

    To enroll in this study at USF please contact Jessica Shaw at (813)974-9413.

    Myotonic Dystrophy type 1 (DM1) Studies

    Updated April 2026

     

    Sanofi DFI17808 (BrAAVe)

    -Enrolling NOW!

    A Study to Investigate the Safety, Tolerability, and Efficacy of SAR446268, an Adeno-associated Viral Vector-mediated Gene Therapy in Participants Aged 10 to 50 Years of Age With Non-congenital Myotonic Dystrophy Type 1 (BrAAVe). 

    For more information, please visit:  

    NCT06844214

    To enroll in this study at USF please contact Jessica Shaw at (813)974-9413 or Chandana Chava at 813-905-1036.

    Spasticity studies

    Updated July 2025

    Efgartigimod for Stiff Person Syndrome (ESPS)

    -Enrolling soon!

    More details coming soon! 

    For more information, please visit:

    NCT06528392

    To enroll in this study at USF please contact Jessica Shaw at (813)974-9413.
  • PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort (PPMI)

    Brief summary:

    The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls. 

    The overall goal of PPMI is to identify markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.

    Status: Enrolling

    For more information, please visit:

    PPMI Clinical

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu

    Catalpa

    (IPSEN)

    ID: NCT06937931

    Brief summary: The purpose of this study is to evaluate the efficacy and safety of the study drug, IPN10200, and to assess how well it works when compared with placebo in treating Cervical Dystonia (CD) in adults.

    Status: Enrolling

    For more information, please visit

    Catalpa

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu

    Bluerock

    ID: NCT06944522

    Brief Summary: Study BRT-DA01-301 is a Phase 3 multicenter, randomized, sham surgery-controlled, double-blind study to assess the efficacy and safety of bemdaneprocel in approximately 102 adults with Parkinson's Disease (PD).

    Status: Enrolling

    For more information, please visit:

    Bluerock

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu 

    Annovis

    (A study of Buntanetap in participants with PD)

    ID: NCT07284784

    Brief Summary: This study will examine the long-term safety of buntanetap in participants with PD. This will be a 36-month open-label safety study. This study will be conducted with two cohorts. Cohort 1 will enroll via invitation only for PD participants who have previously participated in buntanetap clinical trials. Cohort 2 will be for PD participants who are receiving deep brain stimulation (DBS) treatment. Qualified participants will receive buntanetap 30mg QD after a screening period of up to 42 days.

    Status: DBS Enrolling

    For more information, please visit:

    Annovis

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu 

    Neulark

    Summary: A Phase 2 Study of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease (NEULARK)

    Status: Enrolling

    For more information, please visit:  

    Neulark

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu 

    Paraiso

    A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease (PARAISO)

    ID: NCT07174310

    Brief Summary: The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of prasinezumab compared with placebo in participants with early-stage Parkinson's disease (PD) on stable symptomatic monotherapy with levodopa.

    Status: Ongoing - closed to enrollment

    For more information, please visit:

    Paraiso

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu 

    Abbvie Rossini

    Real-World Study of ABBV-951 Subcutaneous Infusion to Assess Change in Disease Activity in Adult Participants With Parkinson's Disease (ROSSINI)

    ID: NCT06107426

    Brief Summary: Parkinson's disease (PD) is a neurological condition that affects the brain. PD gets worse over time, but how quickly it progresses varies a lot from person to person. Some symptoms of PD are tremors, stiffness, and slowness of movement. The purpose of this study is to evaluate how effective ABBV-951 is in treating adult participants with advanced PD in a real-world setting.

    Status: Ongoing - closed to enrollment

    For more information, please visit:

    Abbvie Rossini

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu 

    IPX 203-401-23

    (ELEVATE-PD

    ID: NCT06765668

    Brief Summary: The primary purpose of this study is to evaluate the efficacy and safety of CREXONT under real-world conditions in participants with Parkinson's disease (PD).

    Status: Ongoing - closed to enrollment

    For more information, please visit: 

    IPX 203-401-23

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu 

    Padova

    ID: NCT04777331

    Brief Description: This is a multicenter, randomized, double-blind, placebo-controlled study that will evaluate the efficacy and safety of intravenous (IV) prasinezumab versus placebo in participants with Early Parkinson's Disease (PD) who are on stable symptomatic PD medication.

    Status: Ongoing - closed to enrollment

    For more information, please visit:

    Padova

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu 

    Pasadena

    ID: NCT03100149

    Brief summary: This multicenter, randomized, double-blind, placebo-controlled, Phase 2 study will evaluate the efficacy of intravenous prasinezumab (RO7046015/PRX002) versus placebo over 52 weeks in participants with early Parkinson's Disease (PD) who are untreated or treated with monoamine oxidase B (MAO-B) inhibitors since baseline. 

    Status: Ongoing - closed to enrollment

    For more information, please visit

    Pasadena

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu 

    TEVA

    ID: NCT06568237

    Brief summary: A Study to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy (MSA): A Safety and Efficacy Study (TOPAS-MSA)

    Status: Ongoing - closed to enrollment

    For more information, please visit:

    TEVA

    For more information, please contact:

    Anja Jankovic
    (813) 396-2008

    mcom-parkinsons@usf.edu

  • ARCADIA

    Currently Enrolling

    Multicenter, biomarker-driven, randomized, double-blind, active-control, phase 3 clinical trial of apixaban versus aspirin in patients with cryptogenic stroke. The purpose of this study is to determine if apixaban is superior to aspirin for the prevention of recurrent stroke in patients with cryptogenic ischemic stroke and atrial cardiopathy. 

    For more information on this study please visit this website: https://clinicaltrials.gov/ct2/show/NCT03192215

    To enroll in this study at USF please contact Tara McTigue at (813)259-0826

     BMS CV010 Factor IX inhibitor

    Currently Enrolling

     A Global, Phase 2, Randomized, Double-Blind, Placebo-Controlled, Response-Adaptive Dose- Ranging Study of BMS-986177, an Oral Factor XIa Inhibitor, for the Prevention of New Ischemic Stroke or New Silent Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Non-Hemorrhagic Stroke or Transient Ischemia Attack (TIA). The purpose of this clinical study is to determine whether the addition of an oral Factor XIa Inhibitor to Aspirin and Clopidogrel is more effective than standard therapy in secondary stroke prevention.  For more information on this study please visit this website: https//clinicaltrials.gov/ct2/show/NCT03766581?term=CV010-031&draw=2&rank=1 To enroll in this study at USF please contact Tara McTigue at (813)259-0826

     MOST

    Currently Enrolling

     Multi-arm Optimization of Stroke Thrombolysis (MOST): a blinded, randomized controlled adaptive, multi-arm, adjunctive-thrombolysis efficacy trial in ischemic stroke.   The primary efficacy objective of the MOST trial is to determine if argatroban (100µg/kg bolus followed by 3µg/kg per minute for 12 hours) or eptifibatide (135µg/kg bolus followed by 0.75µg/kg/min infusion for two hours) results in improved 90-day modified Rankin scores (mRS) as compared with placebo in acute ischemic stroke (AIS) patients treated with 0.9mg/kg IV rt-PA within three hours of symptom onset.  For more information on this study please visit this website: https//clinicaltrials.gov/ct2/show/NCT03735979?term=Multi-arm+Optimization+of+Stroke+Thrombolysis&draw=2&rank=1 To enroll in this study at USF please contact Tara McTigue at (813)259-0826

     CHARM

    Currently Enrolling

     Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction  For more information on this study please visit this wesbite: http://https//clinicaltrials.gov/ct2/show/NCT03735979?term=Multi-arm+Optimization+of+Stroke+Thrombolysis&draw=2&rank=1 To enroll in this study at USF please contact Tara McTigue at (813)259-0826

     Pisces (Stem cells) 

    Currently Enrolling

     A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Intracerebral Stem Cells (CTX0E03) in Subjects with Disability Following an Ischemic Stroke   To enroll in this study at USF please contact Tara McTigue at (813)259-0826

    TCSD-S 

    Currently Enrolling 

     Disparities in Transition of Care after Acute Stroke Hospitalization: The Transition of Care Stroke Disparity Study. This study is identifying the disparities in care for patients who are discharged directly home after acute stroke.  For more information on this study please visit this website: http://https//clinicaltrials.gov/ct2/show/NCT03452813?cond=TCSD-S&draw=2&rank=1 To enroll in this study at USF please contact Tara McTigue at (813)259-0826

     Sleep SMART 

    Currently Enrolling

     Sleep for Stroke Management And Recovery Trial. Use of Cpap machine after ischemic stroke   The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.  For more information on this study please visit this website: http://https//clinicaltrials.gov/ct2/show/NCT03812653?term=Sleep+SMART&draw=2&rank=1 To enroll in this study at USF please contact Tara McTigue at (813)259-0826

    ASPIRE

    Currently Enrolling

    Anticoagulation for Stroke Prevention and Recovery after ICH. The goal of this study is to determine if apixaban is superior to aspirin for prevention of the composite outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with recent ICH and atrial fibrillation (AF).  For more information on this study please visit the website: http://https//clinicaltrials.gov/ct2/show/NCT03907046?term=Anticoagulation+for+Stroke+Prevention+and+Recovery+after+ICH&draw=2&rank=1 To enroll in this study at USF please contact Tara McTigue at (813)259-0826
     Pacific-Stroke (Bayer) (Pending) The purpose of this study is to try to find the best dose of the study drug to give to participants and to look at how well BAY 2433334 works in preventing another stroke, whether the study drug is safe for the participants, and how it affects the body. This study is also done to learn how the study drug moves into, through and out of the body.  For more information on this study please visit the website: http://https//clinicaltrials.gov/ct2/show/NCT04304508?term=Pacific-Stroke&draw=2&rank=1 To enroll in this study at USF please contact Tara McTigue at (813)259-0826