Molecular Medicine

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John Tsibris

John Tsibris, PhD

Professor Emeritus, Obstetrics and Gynecology

Contact Info

Education

  • PHD, Biochemistry, Cornell University, 1966
  • BS, Chemistry, University of Athens, 1959

Biography

Included in my CV updated on 7-18-24

Academic Philosophy

"Since basic scientists in clinical departments have easier access to human tissues, they are obligated to explore complex issues, such as the tissue microenvironment, with new technologies as they train the new generations of physicians."

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cellular and Molecular Biology
  • Women & Children's Health

Research Interests

  • • Tissue-based interactome maps of human placentas have revealed interactions of VEGFR2, MDMX, PICALM, Oxytocin Receptor and Vasopressin Receptor AVPR1a in chorionic villi. Protein levels of these proteins correlate with clinical parameters diagnoses of our patient cohort revealing their participation in metabolic networks that operate in pregnancy comorbidities, such as preeclampsia, diabetes, obesity and in labor.
  • • Cervical mucus Guaiacol Peroxidase activity (GPx) can define the fertile period of women. GPx can tag and help identify proteins associated with GPx during the menstrual cycle that could control mucus structure and function. Moreover, GPx can be used in proximity studies to map proteins in cervical mucus and possibly in lung mucus of reproductive age women.

Awards/Honors

  • Carrer Development Award AM-42386 (NIH - 1969)
  • Carrer Development Award GM-42386 (NIH - 1972)
  • Inventor of the Year Award (University of Illinois at Chicago - 1986)
  • Professional Excellence Award (University of South Florida - 1999)
  • Charter Member (National Academy of Inventors - 2009)

Memberships

  • Member (Society for Reproductive Investigation, 1980 - Present)
  • Member (American Society for Biochemistry and Molecular Biology, 1970 - Present)
  • Member (American Chemical Society, 1967 - Present)

Recent Publications

  • Mong EF, Yang Y, Akat KM, Canfield J, VanWye J, Lockhart J, Tsibris JCM, Schatz F, Lockwood CJ, Tuschl T, Kayisli UA, Totary-Jain H. Chromosome 19 microRNA cluster enhances cell reprogramming by inhibiting epithelial-to-mesenchymal transition. Scientific reports. 10(1) : 3029, 2020.
  • S. J. Ho, D. Chaput, R. G. Sinkey, A.H. Garces, E.P. New, M. Okuka, P. Sang, S. Arlier, N.Semerci, T. S. Steffensen, T. J. Rutherford, A. E. Alsina, J. Cai, M. L. Anderson, R. R. Magness, V. N. Uversky, D. A. T. Cummings & J. C. M. Tsibris Proteomic studies of VEGFR2 in human placentas reveal protein associations with preeclampsia, diabetes, gravidity, and labor Cell Communication and Signaling. 22(1) : 221-, 2024.
  • SJ Ho, D Chaput, RG Sinkey, AH Garces, EP New, M Okuka, P Sang, S Arlier, N Semerci, TS Steffensen, TJ Rutherford, AE Alsina, J Cai, ML Anderson, RR Magnes, VN Uversky, DAT Cummings, JCM Tsibris Proteomic studies of human placentas reveal partnerships associated with preeclampsia, diabetes, gravidity, and labor MedRχiv. , 2023.