Molecular Medicine

Laura J. Blair

Laura J. Blair, PhD

Assistant Professor, College of Medicine Molecular Medicine

Contact Info 4001 E Fletcher Ave
MDC 36
Tampa FL 33620

Academic Email: laurablair@usf.edu

Academic Phone:(813) 396-0639

View My C.V.

Education

  • PhD, Medical Sciences, University of South Florida, 2014
  • MS, Medical Sciences, University of South Florida, 2013
  • BA, Chemistry, USF, 2009

Interdisciplinary and Emerging Signature Programs

  • Neuroscience

Memberships

  • ISTAART (Member, 2017 - Present)
  • Society for Neuroscience (Memeber, 2014 - Present)
  • Society for Neuroscience (Student Member, 2009 - 2014)

Recent Publications

  • Darling AL, Breydo L, Rivas EG, Gebru NT, Zheng D, Baker JD, Blair LJ, Dickey CA, Koren J, Uversky VN. Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins. International journal of biological macromolecules. 127: 136-145, 2019. http://www.ncbi.nlm.nih.gov/pubmed/30639592
  • Blair LJ, Criado-Marrero M, Zheng D, Wang X, Kamath S, Nordhues BA, Weeber EJ, Dickey CA. The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling. eNeuro. 6(1) , 2019. http://www.ncbi.nlm.nih.gov/pubmed/30963102
  • Blair LJ, Genest O, Mollapour M. The multiple facets of the Hsp90 machine. Nature structural & molecular biology. 26(2) : 92-95, 2019. http://www.ncbi.nlm.nih.gov/pubmed/30617298
  • Criado-Marrero M, Gebru NT, Gould LA, Smith TM, Kim S, Blackburn RJ, Dickey CA, Blair LJ. Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus. International journal of molecular sciences. 20(11) , 2019. http://www.ncbi.nlm.nih.gov/pubmed/31167373
  • Sabbagh JJ, Cordova RA, Zheng D, Criado-Marrero M, Lemus A, Li P, Baker JD, Nordhues BA, Darling AL, Martinez-Licha C, Rutz DA, Patel S, Buchner J, Leahy JW, Koren J, Dickey CA, Blair LJ. Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD. ACS chemical biology. 13(8) : 2288-2299, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29893552
  • Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M. Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature communications. 9(1) : 4532, 2018. http://www.ncbi.nlm.nih.gov/pubmed/30382094
  • Criado-Marrero M, Rein T, Binder EB, Porter JT, Koren J, Blair LJ. Hsp90 and FKBP51: complex regulators of psychiatric diseases. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 373(1738) , 2018. http://www.ncbi.nlm.nih.gov/pubmed/29203717
  • Baker JD, Ozsan I, Rodriguez Ospina S, Gulick D, Blair LJ. Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease. International journal of molecular sciences. 20(1) , 2018. http://www.ncbi.nlm.nih.gov/pubmed/30585227
  • Shelton LB, Koren J, Blair LJ. Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies. Frontiers in neuroscience. 11: 724, 2017. http://www.ncbi.nlm.nih.gov/pubmed/29311797
  • Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J, Dickey CA. Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma. Scientific reports. 7(1) : 17951, 2017. http://www.ncbi.nlm.nih.gov/pubmed/29263415
  • Shelton LB, Baker JD, Zheng D, Sullivan LE, Solanki PK, Webster JM, Sun Z, Sabbagh JJ, Nordhues BA, Koren J, Ghosh S, Blagg BSJ, Blair LJ, Dickey CA. Hsp90 activator Aha1 drives production of pathological tau aggregates. Proceedings of the National Academy of Sciences of the United States of America. , 2017. http://www.ncbi.nlm.nih.gov/pubmed/28827321
  • Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, Zweckstetter M, Dickey CA, Koren J, Blair LJ. Human cyclophilin 40 unravels neurotoxic amyloids. PLoS biology. 15(6) : e2001336, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28654636
  • Zheng D, Sabbagh JJ, Blair LJ, Darling AL, Wen X, Dickey CA. MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation. The Journal of biological chemistry. 291(34) : 17897-906, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27334923
  • Sabbagh JJ, Fontaine SN, Shelton LB, Blair LJ, Hunt JB, Zhang B, Gutmann JM, Lee DC, Lloyd JD, Dickey CA. Noncontact Rotational Head Injury Produces Transient Cognitive Deficits but Lasting Neuropathological Changes. Journal of neurotrauma. 33(19) : 1751-1760, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26739819
  • Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM, Dickey CA. DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins. The EMBO journal. 35(14) : 1537-49, 2016. http://www.ncbi.nlm.nih.gov/pubmed/27261198
  • Blair LJ, Frauen HD, Zhang B, Nordhues BA, Bijan S, Lin YC, Zamudio F, Hernandez LD, Sabbagh JJ, Selenica ML, Dickey CA. Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy. Acta neuropathologica communications. 3: 8, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25775028
  • Blair LJ, Baker JD, Sabbagh JJ, Dickey CA. The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease. Journal of neurochemistry. 133(1) : 1-13, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25628064
  • Blair LJ, Sabbagh JJ, Dickey CA. Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease. Expert opinion on therapeutic targets. 18(10) : 1219-32, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25069659
  • Sabbagh JJ, O'Leary JC, Blair LJ, Klengel T, Nordhues BA, Fontaine SN, Binder EB, Dickey CA. Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency. PloS one. 9(9) : e107241, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25191701
  • Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. Journal of neuroinflammation. 11: 152, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25183004
  • Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(4) : 1450-9, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23271055
  • Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, Binder EB, Kayed R, Golde TE, Berchtold N, Dickey CA. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of clinical investigation. 123(10) : 4158-69, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23999428
  • Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(22) : 9498-507, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23719816
  • Abisambra JF Jinwal UK Miyata Y Rogers J Blair L Li X Seguin SP Wang L Jin Y Bacon J et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry. 74: 367-374., 2013.
  • O'Leary JC 3rd B, Zhang Koren J III Blair LJ Dickey CA. The Role of FKBP5 in Mood Disorders: Action of FKBP5 on Steroid Hormone Receptors Leads to Questions About its Evolutionary Importance. CNS Neurol Disord Drug Targets.. 12(8) : 1157-62, 2013.
  • Blair LJ, Zhang B, Dickey CA. Potential synergy between tau aggregation inhibitors and tau chaperone modulators. Alzheimer's research & therapy. 5(5) : 41, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24041111
  • Suntharalingam A O'Leary JC III Koren J III Joe MK Blair LJ Hill SE Abisambra JF Jinwal UK Cockman M Duerfeldt AS Rapoport T Ye Y Tomarev S Blagg BSJ Lieberman RL and Dickey CA. Grp94 depletion shunts mutant myocilin away from ERAD towards a more efficient clearance mechanism. Journal of Biological Chemistry.. 287(48) : 40661-40669., 2012.
  • Suntharalingam A, Abisambra JF, O'Leary JC, Koren J, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism. The Journal of biological chemistry. 287(48) : 40661-9, 2012. http://www.ncbi.nlm.nih.gov/pubmed/23035116
  • Koren J, Miyata Y, Kiray J, O'Leary JC, Nguyen L, Guo J, Blair LJ, Li X, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PloS one. 7(4) : e35566, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22563386
  • Abisambra JF Jinwal UK Jones JR Blair LJ Koren J 3rd Dickey CA. Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Current Neuropharmacology.. 9(4) : 623-31., 2011.
  • O'Leary JC, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA. A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51. PloS one. 6(9) : e24840, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21935478
  • O'Leary JC III Dharia S Blair LJ Brady S Johnson AG Peters M Cheung-Flynn J Cox MB de Erausquin G Weeber EJ Jinwal UK Dickey CA. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PLoS One.. 6(9) : e24840., 2011.
  • Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA. The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. Journal of natural products. 74(1) : 38-44, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21141876
  • Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. The Journal of biological chemistry. 285(4) : 2498-505, 2010. http://www.ncbi.nlm.nih.gov/pubmed/19889640
  • Jinwal UK, Koren J, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC, Jin Y, Buchner J, Cox MB, Dickey CA. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(2) : 591-9, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20071522
  • O'Leary JC, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular neurodegeneration. 5: 45, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21040568
  • Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, Weeber EJ, Banko J, Dickey CA. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(46) : 15374-82, 2010. http://www.ncbi.nlm.nih.gov/pubmed/21084594
  • Jinwal UK, O'Leary JC, Borysov SI, Jones JR, Li Q, Koren J, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Hsc70 rapidly engages tau after microtubule destabilization. The Journal of biological chemistry. 285(22) : 16798-805, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20308058
  • Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, Johnson A, Blair L, Gordon MN, Dickey CA, Morgan D. LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. Journal of neuroinflammation. 7: 56, 2010. http://www.ncbi.nlm.nih.gov/pubmed/20846376
  • Koren J, Jinwal UK, Lee DC, Jones JR, Shults CL, Johnson AG, Anderson LJ, Dickey CA. Chaperone signalling complexes in Alzheimer's disease. Journal of cellular and molecular medicine. 13(4) : 619-30, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19449461
  • Dickey C, Kraft C, Jinwal U, Koren J, Johnson A, Anderson L, Lebson L, Lee D, Dickson D, de Silva R, Binder LI, Morgan D, Lewis J. Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. The American journal of pathology. 174(1) : 228-38, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19074615

Positions Held

  • Postdoctoral Scholar (Molecular Medicine, MCOM, University of South Florida 2014 - 2016)
  • Graduate Research Assistant (Molecular Medicine, MCOM, University of South Florida 2009 - 2014)
  • Research Technician (Molecular Medicine, MCOM, University of South Florida 2008 - 2009)
  • Undergraduate Research (Chemistry, University of South Florida 2006 - 2008)