Rezaul M Karim H-7930-2016

Rezaul M Karim, BPharm, MPharm (MS)

Graduate Research Assistant, College of Medicine Molecular Medicine

Contact Info Schonbrunn Lab
12902 Magnolia dr., Moffitt Cancer Center, SRB 24244
Tampa FL 33612

Academic Email: rezaul@health.usf.edu

Academic Phone:(813) 745-5462

Education

  • MS, Medical Sciences, University of South Florida, 2017
  • MS, Pharmaceutical Chemistry, University of Dhaka, 2009
  • BS, Pharmacy, University of Dhaka, 2008

Academic Philosophy

"Open mind, open science!"

Interdisciplinary and Emerging Signature Programs

  • Allergy, Immunology & Infectious Disease
  • Cancer Biology
  • Cellular and Molecular Biology

Research Interests

  • With increasing knowledge of cancer genomes and epigenomes new molecules like bromodomains and histone demethylases, are emerging as promising anticancer targets. In my research, using structural biology and cell biology techniques I focus on the discovery of small molecule inhibitors targeting the epigenetic reader module bromodomain.

Recent Publications

  • Nerlakanti N, Yao J, Nguyen DT, Patel AK, Eroshkin AM, Lawrence HR, Ayaz M, Kuenzi BM, Agarwal N, Chen Y, Gunawan S, Karim RM, Berndt N, Puskas J, Magliocco AM, Coppola D, Dhillon J, Zhang J, Shymalagovindarajan S, Rix U, Kim Y, Perera R, Lawrence NJ, Schonbrunn E, Mahajan K. Targeting the BRD4-HOXB13 Co-regulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer. Molecular cancer therapeutics. , 2018. http://www.ncbi.nlm.nih.gov/pubmed/30242092
  • Akuffo AA, Alontaga AY, Metcalf R, Beatty MS, Becker A, McDaniel JM, Hesterberg RS, Goodheart WE, Gunawan S, Ayaz M, Yang Y, Karim MR, Orobello ME, Daniel K, Guida W, Yoder JA, Rajadhyaksha AM, Schönbrunn E, Lawrence HR, Lawrence NJ, Epling-Burnette PK. Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon. The Journal of biological chemistry. 293(16) : 6187-6200, 2018. http://www.ncbi.nlm.nih.gov/pubmed/29449372
  • Berndt N, Karim RM, Schönbrunn E. Advances of small molecule targeting of kinases. Current opinion in chemical biology. 39: 126-132, 2017. http://www.ncbi.nlm.nih.gov/pubmed/28732278
  • Karim RM, Schönbrunn E. An Advanced Tool To Interrogate BRD9. Journal of medicinal chemistry. , 2016. http://www.ncbi.nlm.nih.gov/pubmed/27120693

Positions Held

  • Lecturer (Pharmacy, Northern University 2010 - 2012)
  • Brand Executive (Strategic Brand Management, Beximco Pharmaceuticals 2009 - 2010)